6.1.1.13: D-alanine-poly(phosphoribitol) ligase
This is an abbreviated version!
For detailed information about D-alanine-poly(phosphoribitol) ligase, go to the full flat file.
Word Map on EC 6.1.1.13
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6.1.1.13
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d-alanylation
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lipoteichoic
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lactobacillus
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casei
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d-alanyl-lipoteichoic
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dltd
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teichoic
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neuhaus
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thioesters
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peptidyl
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4'-phosphopantetheine
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mischarged
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fischer
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esterification
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amphiphile
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permeabilized
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synthetases
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mutans
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heaton
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bacteriol
- 6.1.1.13
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d-alanylation
-
lipoteichoic
- lactobacillus
- casei
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d-alanyl-lipoteichoic
- dltd
-
teichoic
-
neuhaus
- thioesters
-
peptidyl
- 4'-phosphopantetheine
-
mischarged
-
fischer
- esterification
-
amphiphile
-
permeabilized
- synthetases
- mutans
-
heaton
-
bacteriol
Reaction
Synonyms
D-Alanine-activating enzyme, D-Alanine-membrane acceptor ligase, D-Alanine: membrane acceptor ligase, D-alanyl carrier protein, D-Alanyl-poly-(phosphoribitol) synthetase, DAE, Dcl, DCP, Dlt, DltC
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Substrates Products
Substrates Products on EC 6.1.1.13 - D-alanine-poly(phosphoribitol) ligase
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REACTION DIAGRAM
ATP + D-2-amino-n-butyric acid + membrane fragments
D-2-Amino-n-butryl-membrane fragments + AMP + diphosphate
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not L-2-amino-n-butyric acid
-
?
ATP + D-Ala + D-alanyl carrier protein
D-Alanyl-D-alanyl carrier protein + AMP + diphosphate
ATP + D-Ala + hydroxylamine
D-Alanine hydroxamate + AMP + diphosphate
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D-Ala can be substituted by D-2-amino-n-butyric acid with 14.6% and D-Ser with 7.5% efficiency
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?
ATP + D-Ala + membrane fragments
D-Alanyl-membrane fragments + AMP + diphosphate
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ATP can be substituted by ADP, GTP, CTP, UTP, not by AMP, D-Ala cannot be substituted by L-Ala
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?
ATP + D-alanine + D-alanyl lipoteichoic acid
AMP + diphosphate + D-alanyl lipoteichoic acid
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-
-
-
?
ATP + D-alanine + poly(ribitol phosphate)
AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)
D-Alanyl-D-alanyl carrier protein + AMP + diphosphate
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two-step reaction with a high-energy D-Ala-AMP intermediate
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?
ATP + D-Ala + D-alanyl carrier protein
D-Alanyl-D-alanyl carrier protein + AMP + diphosphate
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D-alanyl carrier protein is a protein of MW 6200, cloned and expressed in E. coli
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-
?
AMP + diphosphate + D-alanyl teichoic acid
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-
-
-
?
ATP + D-alanine + D-alanyl teichoic acid
AMP + diphosphate + D-alanyl teichoic acid
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-
-
-
?
AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)
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-
-
r
ATP + D-alanine + poly(ribitol phosphate)
AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)
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the enzyme is required for D-alanylation of membrane-associated lipoteichoic acid in Gram-positive organisms. Dcp has a unique binding site which interacts with the poly(Gro-P) moiety of lipoteichoic acid. The reversibility of this process provides a mechanism for the transacylation of the D-alanyl ester residues between lipoteichoic acids and wall teichoic acids
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r
ATP + D-alanine + poly(ribitol phosphate)
AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)
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-
-
r
ATP + D-alanine + poly(ribitol phosphate)
AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)
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the enzyme is required for D-alanylation of membrane-associated lipoteichoic acid in Gram-positive organisms. Dcp has a unique binding site which interacts with the poly(Gro-P) moiety of lipoteichoic acid. The reversibility of this process provides a mechanism for the transacylation of the D-alanyl ester residues between lipoteichoic acids and wall teichoic acids
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r
ATP + D-alanine + poly(ribitol phosphate)
AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)
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-
-
?
ATP + D-alanine + poly(ribitol phosphate)
AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)
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biosynthesis of teichoic acids
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?
ATP + D-alanine + poly(ribitol phosphate)
AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)
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-
-
?
ATP + D-alanine + poly(ribitol phosphate)
AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)
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biosynthesis of teichoic acids
-
?