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6.1.1.13: D-alanine-poly(phosphoribitol) ligase

This is an abbreviated version!
For detailed information about D-alanine-poly(phosphoribitol) ligase, go to the full flat file.

Word Map on EC 6.1.1.13

Reaction

ATP
+
D-alanine
+
poly(ribitol phosphate)
=
AMP
+
diphosphate
+
O-D-alanyl-poly(ribitol phosphate)

Synonyms

D-Alanine-activating enzyme, D-Alanine-membrane acceptor ligase, D-Alanine: membrane acceptor ligase, D-alanyl carrier protein, D-Alanyl-poly-(phosphoribitol) synthetase, DAE, Dcl, DCP, Dlt, DltC

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.13 D-alanine-poly(phosphoribitol) ligase

Substrates Products

Substrates Products on EC 6.1.1.13 - D-alanine-poly(phosphoribitol) ligase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + D-2-amino-n-butyric acid + membrane fragments
D-2-Amino-n-butryl-membrane fragments + AMP + diphosphate
show the reaction diagram
-
not L-2-amino-n-butyric acid
-
?
ATP + D-Ala + D-alanyl carrier protein
D-Alanyl-D-alanyl carrier protein + AMP + diphosphate
show the reaction diagram
ATP + D-Ala + hydroxylamine
D-Alanine hydroxamate + AMP + diphosphate
show the reaction diagram
-
D-Ala can be substituted by D-2-amino-n-butyric acid with 14.6% and D-Ser with 7.5% efficiency
-
?
ATP + D-Ala + membrane fragments
D-Alanyl-membrane fragments + AMP + diphosphate
show the reaction diagram
-
ATP can be substituted by ADP, GTP, CTP, UTP, not by AMP, D-Ala cannot be substituted by L-Ala
-
?
ATP + D-alanine + D-alanyl lipoteichoic acid
AMP + diphosphate + D-alanyl lipoteichoic acid
show the reaction diagram
-
-
-
-
?
ATP + D-alanine + D-alanyl teichoic acid
AMP + diphosphate + D-alanyl teichoic acid
show the reaction diagram
ATP + D-alanine + poly(ribitol phosphate)
AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)
show the reaction diagram
ATP + diphosphate
ATP + diphosphate
show the reaction diagram
-
-
-
?
D-Alanine + ATP + ?
?
show the reaction diagram
-
biosynthesis of teichoic acid
-
-
?