6.1.1.13: D-alanine-poly(phosphoribitol) ligase

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For detailed information about D-alanine-poly(phosphoribitol) ligase, go to the full flat file.

Reaction

Synonyms

D-Alanine-activating enzyme, D-Alanine-membrane acceptor ligase, D-Alanine: membrane acceptor ligase, D-alanyl carrier protein, D-Alanyl-poly-(phosphoribitol) synthetase, DAE, Dcl, DCP, Dlt, DltC

ECTree

     6 Ligases

         6.1 Forming carbon-oxygen bonds

             6.1.1 Ligases forming aminoacyl-tRNA and related compounds

                6.1.1.13 D-alanine-poly(phosphoribitol) ligase

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Results	in table
1	Activating Compound
623	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
2	Cofactor
1	Crystallization (Commentary)
10	Inhibitors
7	KM Value [mM]
2	Localization
6	Metals/Ions
1	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
111	Organism
2	Pathway
16	PDB ID
3	pH Optimum
3	Purification (Commentary)
1	Reaction
1	Reaction Type
11	Reference
1	Specific Activity [micromol/min/mg]
2	Storage Stability
18	Substrates and Products (Substrate)
16	Synonyms
1	Systematic Name

Natural Substrates Products

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Natural Substrates Products on EC 6.1.1.13 - D-alanine-poly(phosphoribitol) ligase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

ATP + D-alanine + D-alanyl lipoteichoic acid

AMP + diphosphate + D-alanyl lipoteichoic acid

Staphylococcus epidermidis

-

-

726624

-

-

?

ATP + D-alanine + D-alanyl teichoic acid

AMP + diphosphate + D-alanyl teichoic acid

2 entries

ATP + D-alanine + poly(ribitol phosphate)

AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)

4 entries

D-Alanine + ATP + ?

?

Lacticaseibacillus casei

-

biosynthesis of teichoic acid

1056

-

-

?

ATP + D-alanine + D-alanyl teichoic acid

AMP + diphosphate + D-alanyl teichoic acid

Bacillus subtilis

-

-

727754

-

-

?

ATP + D-alanine + D-alanyl teichoic acid

AMP + diphosphate + D-alanyl teichoic acid

Bacillus subtilis 168

-

-

727754

-

-

?

ATP + D-alanine + poly(ribitol phosphate)

AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)

Lacticaseibacillus casei

-

the enzyme is required for D-alanylation of membrane-associated lipoteichoic acid in Gram-positive organisms. Dcp has a unique binding site which interacts with the poly(Gro-P) moiety of lipoteichoic acid. The reversibility of this process provides a mechanism for the transacylation of the D-alanyl ester residues between lipoteichoic acids and wall teichoic acids

651678

-

651678

r

ATP + D-alanine + poly(ribitol phosphate)

AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)

Lacticaseibacillus casei 102S

-

the enzyme is required for D-alanylation of membrane-associated lipoteichoic acid in Gram-positive organisms. Dcp has a unique binding site which interacts with the poly(Gro-P) moiety of lipoteichoic acid. The reversibility of this process provides a mechanism for the transacylation of the D-alanyl ester residues between lipoteichoic acids and wall teichoic acids

651678

-

651678

r

ATP + D-alanine + poly(ribitol phosphate)

AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)

Lacticaseibacillus rhamnosus

-

biosynthesis of teichoic acids

651652

-

651652

?

ATP + D-alanine + poly(ribitol phosphate)

AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)

Lacticaseibacillus rhamnosus 7469

-

biosynthesis of teichoic acids

651652

-

651652

?