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6.1.1.11: serine-tRNA ligase

This is an abbreviated version!
For detailed information about serine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.11

Reaction

ATP
+
L-serine
 +
tRNASer
=
AMP
 +
diphosphate
 +
L-seryl-tRNASer

Synonyms

62 kDa RNA-binding protein, bacterial SerRS, bacterial type seryl-tRNA synthetase, bacterial-type SerRS, bMbSerRS, methanogenic SerRS, methanogenic type seryl-tRNA synthetase, methanogenic-type SerRS, methanogenic-type SerRSs, methanogenic-type seryl-tRNA synthetase, mMbSerRS, mSerRS, mtSerRS, SARS, SCSerS, Serine transfer RNA synthetase, Serine translase, Serine--tRNA ligase, SerRS, SerRS1, SerRS2, SerRSmt, serS, SERSEC, seryl tRNA synthetase, Seryl-transfer ribonucleate synthetase, Seryl-transfer ribonucleic acid synthetase, Seryl-transfer RNA synthetase, Seryl-tRNA synthetase, seryl-tRNA synthetase 1, seryl-tRNA synthetase 2, seryl-tRNA-synthetase, SerZMo, STS, subclass IIa dimeric SerRS, SvsR, Synthetase, seryl-transfer ribonucleate, tRNASer/seryl-tRNA synthetase, ttSerRS, TT_C0520, VlmL, ZmSerS

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.11 serine-tRNA ligase

Inhibitors

Inhibitors on EC 6.1.1.11 - serine-tRNA ligase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(E)-3-(3-ethynyl-4-hydroxyphenyl)-1-(2-hydroxy-4-methoxy-3-(3-methylbut-2-en-1-yl)phenyl)prop-2-en-1-one
-
-
2-mercaptoethanol
-
-
4-hydroxyderricin
-
-
5'-O-[N-(L-Seryl)-sulfamoyl]adenosine
diphosphate
-
-
DL-Serine hydroxamate
GSSG
about 16% residual activity at 1 mM
Mg2+
-
inhibition by dead-end complex formation between the ternary complex, E-ATP-Ser, and either free Mg2+ or Mg2P2O7
p-hydroxymercuribenzoate
Phenylalanyl adenosine 5'-phosphate
-
-
Poly-arginine
-
-
serinamide
-
inhibition of methanogenic type seryl-tRNA synthetase, no inhibition of bacterial type seryl-tRNA synthetase
serine hydroxamate
serine methyl ester
-
-
Seryl adenosine 5'-phosphate
-
-
siRNA
-
-
-
tRNASer-C-C
-
weak
-
tRNASer-C-C-3'dA
-
weak
-
tRNASer-C-C-Aoxi
-
weak
-
tRNASer-C-C-Foxi-red
-
weak
-
tRNASer-I-G-A oxidized with NaIO4
-
-
-
additional information
-
Trypanosoma brucei is highly sensitive to the action of specific selenoprotein inhibitors
-