6.1.1.11: serine-tRNA ligase

This is an abbreviated version!
For detailed information about serine-tRNA ligase, go to the full flat file.

Reaction

Synonyms

62 kDa RNA-binding protein, bacterial SerRS, bacterial type seryl-tRNA synthetase, bacterial-type SerRS, bMbSerRS, methanogenic SerRS, methanogenic type seryl-tRNA synthetase, methanogenic-type SerRS, methanogenic-type SerRSs, methanogenic-type seryl-tRNA synthetase, mMbSerRS, mSerRS, mtSerRS, SARS, SCSerS, Serine transfer RNA synthetase, Serine translase, Serine--tRNA ligase, SerRS, SerRS1, SerRS2, SerRSmt, serS, SERSEC, seryl tRNA synthetase, Seryl-transfer ribonucleate synthetase, Seryl-transfer ribonucleic acid synthetase, Seryl-transfer RNA synthetase, Seryl-tRNA synthetase, seryl-tRNA synthetase 1, seryl-tRNA synthetase 2, seryl-tRNA-synthetase, SerZMo, STS, subclass IIa dimeric SerRS, SvsR, Synthetase, seryl-transfer ribonucleate, tRNASer/seryl-tRNA synthetase, ttSerRS, TT_C0520, VlmL, ZmSerS

ECTree

     6 Ligases

         6.1 Forming carbon-oxygen bonds

             6.1.1 Ligases forming aminoacyl-tRNA and related compounds

                6.1.1.11 serine-tRNA ligase

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Results	in table
4	Activating Compound
52055	AA Sequence
2	Application
1	CAS Registry Number
47	Cloned(Commentary)
48	Cofactor
17	Crystallization (Commentary)
155	Disease/ Diagnostics
2	Expression
18	General Information
5	General Stability
1	IC50 Value
34	Inhibitors
15	kcat/KM [mM/s]
12	Ki Value [mM]
151	KM Value [mM]
23	Localization
33	Metals/Ions
24	Molecular Weight [Da]
61	Natural Substrates/ Products (Substrates)
303	Organism
6	Pathway
101	PDB ID
27	pH Optimum
2	pH Range
2	pH Stability
2	pI Value
80	Protein Variants
34	Purification (Commentary)
9	Reaction
32	Reaction Type
110	Reference
1	Renatured (Commentary)
30	Source Tissue
12	Specific Activity [micromol/min/mg]
3	Storage Stability
188	Substrates and Products (Substrate)
27	Subunits
264	Synonyms
1	Systematic Name
22	Temperature Optimum [°C]
4	Temperature Stability [°C]
117	Turnover Number [1/s]

General Stability

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General Stability on EC 6.1.1.11 - serine-tRNA ligase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

EDTA, 10-50 mM, stabilizes purified enzyme at 2-4°C and at 37°C, no protective effect at 45°C

Saccharomyces cerevisiae

-

80

glycerol and DTT enhance stability of the enzyme

Bombyx mori

-

97

glycerol stabilizes at low pH

Escherichia coli

-

81

not particularly susceptible to inactivation from by freezing and thawing

Bombyx mori

-

97

unstable to dialysis against 0.15 M KCl for 3 h at 4°C

Bos taurus

-

79