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6.1.1.1: tyrosine-tRNA ligase

This is an abbreviated version!
For detailed information about tyrosine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.1

Reaction

ATP
+
L-tyrosine
+
tRNATyr
=
AMP
+
diphosphate
+
L-tyrosyl-tRNATyr

Synonyms

CHOTyrRS, class I tyrosyl-tRNA synthetase, CYT-18, CYT-18 protein, dTyRS, hTyrRS, LdTyrRS, LMJF_14_1370, mini-tyrosyl-tRNA synthetase, mini-TyrRS, mitochondrial tyrosyl-tRNA synthetase, MjYRS, mt-TyrRS, mtTyrRS, NpAla TyrRS, p-BrPhe TyrRS, tRNATyr/tyrosyl-tRNA synthetase, Tyrosine translase, Tyrosine tRNA synthetase, Tyrosine--tRNA ligase, Tyrosine-transfer ribonucleate synthetase, Tyrosine-transfer RNA ligase, tyrosyl aminoacyl-tRNA synthetase, tyrosyl synthetase, tyrosyl tRNA synthetase, Tyrosyl--tRNA ligase, Tyrosyl-transfer ribonucleate synthetase, Tyrosyl-transfer ribonucleic acid synthetase, Tyrosyl-transfer RNA synthetase, Tyrosyl-tRNA ligase, Tyrosyl-tRNA synthetase, tyrosyl—tRNA synthetase, TyrRS, TyrRSs, TyrRZ, tyrS, TYS1, YARS, YRS, YTS

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.1 tyrosine-tRNA ligase

Natural Substrates Products

Natural Substrates Products on EC 6.1.1.1 - tyrosine-tRNA ligase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 3-(2-naphthyl)alanine + tRNATyr
AMP + diphosphate + 3-(2-naphthyl)alanyl-tRNATyr
show the reaction diagram
activity of a natural mutant enzyme, NpAla TyrRS activity
-
-
?
ATP + 4-acetylphenylalanine + tRNATyr
AMP + diphosphate + 4-acetylphenylalanyl-tRNATyr
show the reaction diagram
activity of a natural mutant enzyme
-
-
?
ATP + 4-bromophenylalanine + tRNATyr
AMP + diphosphate + 4-bromophenylalanyl-tRNATyr
show the reaction diagram
activity of a natural mutant enzyme, p-BrPhe TyrRS activity
-
-
?
ATP + L-beta-(5-hydroxy-2-pyridyl)-alanine + tRNATyr
AMP + L-beta-(5-hydroxy-2-pyridyl)-alanine-tRNATyr + diphosphate
show the reaction diagram
-
L-beta-(5-hydroxy-2-pyridyl)-alanine i.e. azatyrosine, mutant F130S shows 17fold higher activity in vivo than the wild-type enzyme
-
?
ATP + L-tyrosine + tRNATyr
AMP + diphosphate + L-tyrosyl-tRNATyr
show the reaction diagram
ATP + L-tyrosine + tRNATyr
AMP + L-Tyr-tRNATyr + diphosphate
show the reaction diagram
ATP + tyrosine + tRNATyr
?
show the reaction diagram
-
-
-
-
?
ATP + tyrosine + tRNATyr
AMP + Tyr-tRNATyr + diphosphate
show the reaction diagram
additional information
?
-