6.1.1.1: tyrosine-tRNA ligase

This is an abbreviated version!
For detailed information about tyrosine-tRNA ligase, go to the full flat file.

Reaction

Synonyms

CHOTyrRS, class I tyrosyl-tRNA synthetase, CYT-18, CYT-18 protein, dTyRS, hTyrRS, LdTyrRS, LMJF_14_1370, mini-tyrosyl-tRNA synthetase, mini-TyrRS, mitochondrial tyrosyl-tRNA synthetase, MjYRS, mt-TyrRS, mtTyrRS, NpAla TyrRS, p-BrPhe TyrRS, tRNATyr/tyrosyl-tRNA synthetase, Tyrosine translase, Tyrosine tRNA synthetase, Tyrosine--tRNA ligase, Tyrosine-transfer ribonucleate synthetase, Tyrosine-transfer RNA ligase, tyrosyl aminoacyl-tRNA synthetase, tyrosyl synthetase, tyrosyl tRNA synthetase, Tyrosyl--tRNA ligase, Tyrosyl-transfer ribonucleate synthetase, Tyrosyl-transfer ribonucleic acid synthetase, Tyrosyl-transfer RNA synthetase, Tyrosyl-tRNA ligase, Tyrosyl-tRNA synthetase, tyrosyl�tRNA synthetase, TyrRS, TyrRSs, TyrRZ, tyrS, TYS1, YARS, YRS, YTS

ECTree

     6 Ligases

         6.1 Forming carbon-oxygen bonds

             6.1.1 Ligases forming aminoacyl-tRNA and related compounds

                6.1.1.1 tyrosine-tRNA ligase

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Results	in table
53049	AA Sequence
27	Application
1	CAS Registry Number
48	Cloned(Commentary)
46	Cofactor
27	Crystallization (Commentary)
78	Disease/ Diagnostics
3	Expression
39	General Information
3	General Stability
87	IC50 Value
176	Inhibitors
19	kcat/KM [mM/s]
29	Ki Value [mM]
124	KM Value [mM]
26	Localization
40	Metals/Ions
23	Molecular Weight [Da]
68	Natural Substrates/ Products (Substrates)
177	Organism
4	Pathway
163	PDB ID
34	pH Optimum
2	pH Range
1	pI Value
2	Posttranslational Modification
160	Protein Variants
51	Purification (Commentary)
15	Reaction
57	Reaction Type
140	Reference
32	Source Tissue
19	Specific Activity [micromol/min/mg]
5	Storage Stability
158	Substrates and Products (Substrate)
33	Subunits
196	Synonyms
1	Systematic Name
29	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
83	Turnover Number [1/s]

KI Value

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KI Value on EC 6.1.1.1 - tyrosine-tRNA ligase

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.32 - 2.15

AMP

6 entries

0.048 - 0.23

diphosphate

6 entries

0.076 - 0.42

L-tyrosinyl 1,4-anhydro-D-ribitol-5-O-phosphate

2 entries

0.0057 - 0.15

L-tyrosinyl 1-beta-naphthyl-1,4-anhydro-D-ribitol-5-O-phosphate

2 entries

0.000011

L-tyrosinyl adenylate

Staphylococcus aureus

-

pH 7.9, 37°C

650538

0.00068

L-tyrosinyl N6-benzoyl adenylate

Geobacillus stearothermophilus

-

pH 7.9, 37°C

650538

0.00021

L-tyrosinyl uridine-5'-O-phosphate

Staphylococcus aureus

-

pH 7.9, 37°C

650538

0.0000093 - 0.000026

L-tyrosinyl-2',3'-O-isopropylidene adenylate

2 entries

0.018 - 0.1

L-tyrosinyl-2'-deoxy adenylate

2 entries

0.036 - 0.14

L-tyrosinyl-3'-deoxy adenylate

2 entries

0.0000063

tyrosinyl adenylate

Geobacillus stearothermophilus

-

pH 7.9, 37°C

650538

additional information

additional information

3 entries

-

0.32

AMP

Geobacillus stearothermophilus

-

in absence of KCl, and in presence of 1 mM free Mg2+, pH 7.4, 30°C

650300

0.35

AMP

Escherichia coli

-

in absence of KCl, pH 7.4, 30°C

650300

0.5

AMP

Escherichia coli

-

in presence of 0.5 mM KCl, pH 7.4, 30°C

650300

0.5

AMP

Geobacillus stearothermophilus

-

in presence of 50 mM KCl, and in presence of 1 mM free Mg2+, pH 7.4, 30°C

650300

0.9

AMP

Escherichia coli

-

in presence of 0.9 mM KCl, pH 7.4, 30°C

650300

2.15

AMP

Geobacillus stearothermophilus

-

in presence of 150 mM KCl, and in presence of 1 mM free Mg2+, pH 7.4, 30°C

650300

0.048

diphosphate

Geobacillus stearothermophilus

-

in presence of 150 mM KCl, and in presence of 1 mM free Mg2+, pH 7.4, 30°C

650300

0.056

diphosphate

Escherichia coli

-

in presence of 0.9 mM KCl, pH 7.4, 30°C

650300

0.1

diphosphate

Geobacillus stearothermophilus

-

in presence of 50 mM KCl, and in presence of 1 mM free Mg2+, pH 7.4, 30°C

650300

0.12

diphosphate

Escherichia coli

-

in presence of 0.5 mM KCl, pH 7.4, 30°C

650300

0.14

diphosphate

Escherichia coli

-

in absence of KCl, pH 7.4, 30°C

650300

0.23

diphosphate

Geobacillus stearothermophilus

-

in absence of KCl, and in presence of 1 mM free Mg2+, pH 7.4, 30°C

650300

0.076

L-tyrosinyl 1,4-anhydro-D-ribitol-5-O-phosphate

Geobacillus stearothermophilus

-

pH 7.9, 37°C

650538

0.42

L-tyrosinyl 1,4-anhydro-D-ribitol-5-O-phosphate

Staphylococcus aureus

-

pH 7.9, 37°C

650538

0.0057

L-tyrosinyl 1-beta-naphthyl-1,4-anhydro-D-ribitol-5-O-phosphate

Geobacillus stearothermophilus

-

pH 7.9, 37°C

650538

0.15

L-tyrosinyl 1-beta-naphthyl-1,4-anhydro-D-ribitol-5-O-phosphate

Staphylococcus aureus

-

pH 7.9, 37°C

650538

0.0000093

L-tyrosinyl-2',3'-O-isopropylidene adenylate

Geobacillus stearothermophilus

-

pH 7.9, 37°C

650538

0.000026

L-tyrosinyl-2',3'-O-isopropylidene adenylate

Staphylococcus aureus

-

pH 7.9, 37°C

650538

0.018

L-tyrosinyl-2'-deoxy adenylate

Geobacillus stearothermophilus

-

pH 7.9, 37°C

650538

0.1

L-tyrosinyl-2'-deoxy adenylate

Staphylococcus aureus

-

pH 7.9, 37°C

650538

0.036

L-tyrosinyl-3'-deoxy adenylate

Geobacillus stearothermophilus

-

pH 7.9, 37°C

650538

0.14

L-tyrosinyl-3'-deoxy adenylate

Staphylococcus aureus

-

pH 7.9, 37°C

650538

additional information

additional information

Staphylococcus aureus

-

-

650572

-

additional information

additional information

Escherichia coli

-

inhibition kinetics

650300

-

additional information

additional information

Geobacillus stearothermophilus

-

inhibition kinetics

650300

-