6.1.1.1: tyrosine-tRNA ligase

This is an abbreviated version!
For detailed information about tyrosine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.1

6.1.1.1

synthetases

aminoacylation

tyrosylation

stearothermophilus

anticodon

amber

jannaschii

trprs

aarss

methanococcus

kmsks

tryptophanyl-trna

charcot-marie-tooth

mischarging

trna-like

d-tyrosine

self-splicing

methanocaldococcus

half-of-the-sites

elr

non-cognate

methionyl-trna

isoleucyl-trna

medicine

biotechnology

sideroblastic

anticodon-binding

tyrts

3-iodo-l-tyrosine

glycyl-trna

drug development

pharmacology

leurs

misacylation

phenylalanyl-trna

fersht

brome

hisrs

Reaction

Synonyms

CHOTyrRS, class I tyrosyl-tRNA synthetase, CYT-18, CYT-18 protein, dTyRS, hTyrRS, LdTyrRS, LMJF_14_1370, mini-tyrosyl-tRNA synthetase, mini-TyrRS, mitochondrial tyrosyl-tRNA synthetase, MjYRS, mt-TyrRS, mtTyrRS, NpAla TyrRS, p-BrPhe TyrRS, tRNATyr/tyrosyl-tRNA synthetase, Tyrosine translase, Tyrosine tRNA synthetase, Tyrosine--tRNA ligase, Tyrosine-transfer ribonucleate synthetase, Tyrosine-transfer RNA ligase, tyrosyl aminoacyl-tRNA synthetase, tyrosyl synthetase, tyrosyl tRNA synthetase, Tyrosyl--tRNA ligase, Tyrosyl-transfer ribonucleate synthetase, Tyrosyl-transfer ribonucleic acid synthetase, Tyrosyl-transfer RNA synthetase, Tyrosyl-tRNA ligase, Tyrosyl-tRNA synthetase, tyrosyl�tRNA synthetase, TyrRS, TyrRSs, TyrRZ, tyrS, TYS1, YARS, YRS, YTS

ECTree

6 Ligases

6.1 Forming carbon-oxygen bonds

6.1.1 Ligases forming aminoacyl-tRNA and related compounds

6.1.1.1 tyrosine-tRNA ligase

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Results	in table
53049	AA Sequence
27	Application
1	CAS Registry Number
48	Cloned(Commentary)
46	Cofactor
27	Crystallization (Commentary)
78	Disease/ Diagnostics
3	Expression
39	General Information
3	General Stability
87	IC50 Value
176	Inhibitors
19	kcat/KM [mM/s]
29	Ki Value [mM]
124	KM Value [mM]
26	Localization
40	Metals/Ions
23	Molecular Weight [Da]
68	Natural Substrates/ Products (Substrates)
177	Organism
4	Pathway
163	PDB ID
34	pH Optimum
2	pH Range
1	pI Value
2	Posttranslational Modification
160	Protein Variants
51	Purification (Commentary)
15	Reaction
57	Reaction Type
140	Reference
32	Source Tissue
19	Specific Activity [micromol/min/mg]
5	Storage Stability
158	Substrates and Products (Substrate)
33	Subunits
196	Synonyms
1	Systematic Name
29	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
83	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 6.1.1.1 - tyrosine-tRNA ligase

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0.1

3-(3,4-dichlorophenyl)-4-(2-(4-methylpiperazin-1-yl)ethoxy)furan-2(5H)-one

Staphylococcus aureus

above, pH not specified in the publication, temperature not specified in the publication

714470

0.1

3-(3,4-difluorophenyl)-4-(2-(piperidin-1-yl)ethoxy)furan-2(5H)-one

Staphylococcus aureus

above, pH not specified in the publication, temperature not specified in the publication

714470

0.1

3-(3,4-dimethoxyphenyl)-4-(2-(4-methylpiperazin-1-yl)ethoxy)furan-2(5H)-one

Staphylococcus aureus

above, pH not specified in the publication, temperature not specified in the publication

714470

0.1

3-(3,4-dimethoxyphenyl)-4-(2-(piperidin-1-yl)ethoxy)furan-2(5H)-one

Staphylococcus aureus

above, pH not specified in the publication, temperature not specified in the publication

714470

0.0243

3-(3-bromophenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one

Staphylococcus aureus

pH not specified in the publication, temperature not specified in the publication

714470

0.0205

3-(3-chlorophenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one

Staphylococcus aureus

pH not specified in the publication, temperature not specified in the publication

714470

0.0256

3-(3-hydroxyphenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one

Staphylococcus aureus

pH not specified in the publication, temperature not specified in the publication

714470

0.0375

3-(3-methoxyphenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one

Staphylococcus aureus

pH not specified in the publication, temperature not specified in the publication

714470

0.0024

3-(4-bromophenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one

Staphylococcus aureus

pH not specified in the publication, temperature not specified in the publication

714470

0.00062

3-(4-chlorophenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one

Staphylococcus aureus

pH not specified in the publication, temperature not specified in the publication

714470

0.0001

3-(4-hydroxyphenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one

Staphylococcus aureus

pH not specified in the publication, temperature not specified in the publication

714470

0.0328

3-(4-methoxyphenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one

Staphylococcus aureus

pH not specified in the publication, temperature not specified in the publication

714470

0.0536

3-phenyl-4-(2-(piperidin-1-yl)ethoxy)furan-2(5H)-one

Staphylococcus aureus

pH not specified in the publication, temperature not specified in the publication

714470

0.0291

3-phenyl-4-(2-(propylamino)ethoxy)furan-2(5H)-one

Staphylococcus aureus

pH not specified in the publication, temperature not specified in the publication

714470

0.0355

3-phenyl-4-(2-(pyrrolidin-1-yl)ethoxy)furan-2(5H)-one

Staphylococcus aureus

pH not specified in the publication, temperature not specified in the publication

714470

0.0165

4-(2-(2,4-dichlorophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0502

4-(2-(2,4-dihydroxyphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0052

4-(2-(2,5-dichlorophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.1

4-(2-(2-(4-nitrophenyl)hydrazinyl)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

above, pH not specified in the publication, temperature not specified in the publication

714470

0.0568

4-(2-(2-chlorophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0414

4-(2-(2-hydroxyphenylformyloxyl)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0647

4-(2-(2-methoxyphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.1

4-(2-(2-methylphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

IC50 above 0.1 mM, in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0182

4-(2-(2-nitrophenylformyloxyl)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0334

4-(2-(3,4-dichlorophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0753

4-(2-(3,4-dihydroxyphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0838

4-(2-(3,4-dimethoxyphenylacetyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0067

4-(2-(3,5-dihydroxyphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0035

4-(2-(3-bromophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0011

4-(2-(3-chlorophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.1

4-(2-(3-chlorophenylacetyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

IC50 above 0.1 mM, in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0009

4-(2-(3-chlorophenylformyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.081

4-(2-(3-methylphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.1

4-(2-(3-nitrophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

IC50 above 0.1 mM, in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.026

4-(2-(3-pyridylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0043

4-(2-(3-trifluoromethylphenylformyoxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0167

4-(2-(4-bromophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0481

4-(2-(4-bromophenylacetyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0093

4-(2-(4-chlorophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0088

4-(2-(4-chlorophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0057

4-(2-(4-fluorophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0936

4-(2-(4-fluorophenylacetyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0075

4-(2-(4-fluorophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0079

4-(2-(4-hydroxyphenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.1

4-(2-(4-hydroxyphenylacetyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

IC50 above 0.1 mM, in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0112

4-(2-(4-hydroxyphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0178

4-(2-(4-methylphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0086

4-(2-(4-methylpiperazin-1-yl)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

pH not specified in the publication, temperature not specified in the publication

714470

0.0052

4-(2-(4-nitrophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0168

4-(2-(6-hydroxynaphthalen-2-ylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.1

4-(2-(benzylamino)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

above, pH not specified in the publication, temperature not specified in the publication

714470

0.0719

4-(2-(butylamino)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

pH not specified in the publication, temperature not specified in the publication

714470

0.1

4-(2-(cyclohexylamino)ethoxy)-3-(3,4-dimethoxyphenyl)furan-2(5H)-one

Staphylococcus aureus

above, pH not specified in the publication, temperature not specified in the publication

714470

0.0874

4-(2-(cyclohexylamino)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

pH not specified in the publication, temperature not specified in the publication

714470

0.0177

4-(2-(naphthalen-2-ylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0846

4-(2-butyryloxyethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0478

4-(2-hexanoyloxyethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0062

4-(2-morpholinoethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

pH not specified in the publication, temperature not specified in the publication

714470

0.041

4-(2-octanoyloxyethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.0128

4-(2-phenylacetyloxylethoxy)-3-phenylfuran-2(5H)-one

Staphylococcus aureus

in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C

727165

0.1

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-bromobenzoate

Staphylococcus aureus

above, pH 7.9, 37°C, recombinant enzyme

745583

0.1

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-chlorobenzoate

Staphylococcus aureus

above, pH 7.9, 37°C, recombinant enzyme

745583

0.1

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-chloropyridine-3-carboxylate

Staphylococcus aureus

above, pH 7.9, 37°C, recombinant enzyme

745583

0.1

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-fluorobenzoate

Staphylococcus aureus

above, pH 7.9, 37°C, recombinant enzyme

745583

0.0921

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-methoxybenzoate

Staphylococcus aureus

pH 7.9, 37°C, recombinant enzyme

745583

0.08862

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-methylbenzoate

Staphylococcus aureus

pH 7.9, 37°C, recombinant enzyme

745583

0.1

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-nitrobenzoate

Staphylococcus aureus

above, pH 7.9, 37°C, recombinant enzyme

745583

0.01898

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-(3-methylphenyl)propanoate

Staphylococcus aureus

pH 7.9, 37°C, recombinant enzyme

745583

0.0111

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-(4-methylphenyl)propanoate

Staphylococcus aureus

pH 7.9, 37°C, recombinant enzyme

745583

0.07109

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-aminobenzoate

Staphylococcus aureus

pH 7.9, 37°C, recombinant enzyme

745583

0.08313

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-bromobenzoate

Staphylococcus aureus

pH 7.9, 37°C, recombinant enzyme

745583

0.08613

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-chlorobenzoate

Staphylococcus aureus

pH 7.9, 37°C, recombinant enzyme

745583

0.08214

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-fluorobenzoate

Staphylococcus aureus

pH 7.9, 37°C, recombinant enzyme

745583

0.07211

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-hydroxybenzoate

Staphylococcus aureus

pH 7.9, 37°C, recombinant enzyme

745583

0.069

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-methylbenzoate

Staphylococcus aureus

pH 7.9, 37°C, recombinant enzyme

745583

0.083

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-phenylpropanoate

Staphylococcus aureus

pH 7.9, 37°C, recombinant enzyme

745583

0.04894

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 4-aminobenzoate

Staphylococcus aureus

pH 7.9, 37°C, recombinant enzyme

745583

0.05117

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 4-bromobenzoate

Staphylococcus aureus

pH 7.9, 37°C, recombinant enzyme

745583

0.05523

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 4-chlorobenzoate

Staphylococcus aureus

pH 7.9, 37°C, recombinant enzyme

745583

0.06514

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 4-fluorobenzoate

Staphylococcus aureus

pH 7.9, 37°C, recombinant enzyme

745583

0.04476

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 4-hydroxybenzoate

Staphylococcus aureus

pH 7.9, 37°C, recombinant enzyme

745583

0.05008

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 4-methylbenzoate

Staphylococcus aureus

pH 7.9, 37°C, recombinant enzyme

745583

0.1

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 6-chloropyridine-3-carboxylate

Staphylococcus aureus

above, pH 7.9, 37°C, recombinant enzyme

745583

0.1

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 6-hydroxypyridine-3-carboxylate

Staphylococcus aureus

above, pH 7.9, 37°C, recombinant enzyme

745583

0.04332

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl benzoate

Staphylococcus aureus

pH 7.9, 37°C, recombinant enzyme

745583

0.1

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl pyridine-3-carboxylate

Staphylococcus aureus

above, pH 7.9, 37°C, recombinant enzyme

745583

0.1

4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl pyridine-4-carboxylate

Staphylococcus aureus

above, pH 7.9, 37°C, recombinant enzyme

745583