5.99.1.4: 2-hydroxychromene-2-carboxylate isomerase

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For detailed information about 2-hydroxychromene-2-carboxylate isomerase, go to the full flat file.

Reaction

(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate

Synonyms

2-hydroxychromene-2-carboxylate isomerase, 2-hydroxychromene-2-carboxylic acid isomerase, 2HC2CA isomerase, 2HCCAI, HCCA isomerase, nsaD

ECTree

5 Isomerases

5.99 Other isomerases

5.99.1 Sole sub-subclass for isomerases that do not belong in the other subclasses

5.99.1.4 2-hydroxychromene-2-carboxylate isomerase

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Results	in table
5	Activating Compound
10914	AA Sequence
2	Cloned(Commentary)
1	Cofactor
1	Crystallization (Commentary)
1	General Stability
7	Inhibitors
1	Ki Value [mM]
5	KM Value [mM]
2	Metals/Ions
5	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
9	Organism
5	Pathway
3	pH Optimum
2	pH Range
1	pH Stability
2	pI Value
3	Purification (Commentary)
1	Reaction
9	Reference
8	Specific Activity [micromol/min/mg]
2	Storage Stability
12	Substrates and Products (Substrate)
6	Subunits
13	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
2	Turnover Number [1/s]

Cofactor

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Cofactor on EC 5.99.1.4 - 2-hydroxychromene-2-carboxylate isomerase

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glutathione

Pseudomonas putida

Q51948

the dimeric protein binds one molecule of GSH very tightly and a second molecule of GSH with much lower affinity. The enzyme is unstable in the absence of GSH. The turnover number in the forward direction greatly exceeds off rates for GSH, suggesting that GSH acts as a tightly bound cofactor in the reaction. Km: 0.017 mM

678289