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5.5.1.8: (+)-bornyl diphosphate synthase

This is an abbreviated version!
For detailed information about (+)-bornyl diphosphate synthase, go to the full flat file.

Word Map on EC 5.5.1.8

Reaction

geranyl diphosphate
=
(+)-bornyl diphosphate

Synonyms

(+)-bornyl diphosphate synthase, (+)-Bornylpyrophosphate cyclase, (+)-BPP cyclase, (-)-BPP cyclase, (di)terpene synthase, bornyl diphosphate synthase, bornyl pyrophosphate synthase, bornyl pyrophosphate synthetase, BPPS, BPS, Geranyl pyrophosphate:(+)-bornyl pyrophosphate cyclase, Geranyl pyrophosphate:(-)-bornyl pyrophosphate cyclase, geranyl-diphosphate cyclase, Synthetase, bornyl pyrophosphate, TPS3

ECTree

     5 Isomerases
         5.5 Intramolecular lyases
             5.5.1 Intramolecular lyases (only sub-subclass identified to date)
                5.5.1.8 (+)-bornyl diphosphate synthase

Inhibitors

Inhibitors on EC 5.5.1.8 - (+)-bornyl diphosphate synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(3R)-homolinalyl diphosphate
-
i.e. 2,6-dimethyl-2-vinyl-5-heptenyl diphosphate
(3R,S)2-fluorolinalyl diphosphate
-
-
(3S)-homolinalyl diphosphate
-
i.e. 2,6-dimethyl-2-vinyl-5-heptenyl diphosphate
(E)-4-[2-Diazo-3-trifluoropropionyloxy]-3-methyl-2-buten-1-ol
-
-
2,3-Dihydrogeranyl diphosphate
-
-
2,3-Epoxygeranyl diphosphate
-
-
2-Fluorogeranyl diphosphate
-
-
2-fluorolinalyl diphosphate
-
-
3-aza-2,3-dihydrogeranyl diphosphate
-
competitive inhibition, the aza-analog of the substrate is bound anomalously, perhaps as a consequence of the positive charge, bond distortion, or hydrogen bonding resulting from the N for C substitution, binding strutcure, overview
6,7-dihydrogeranyl diphosphate
-
-
6,7-Epoxygeranyl diphosphate
-
-
6-cyclopropylidene-(3E)-methyl-hex-2-en-1-yl diphosphate
diisopropylfluorophosphate
-
-
Dimethyl-(4-methylcyclohex-3-en-1-yl)sulfonium iodide
dimethylallyl diphosphate
-
-
diphosphate
-
-
Diphosphoric acid
-
-
Imidodiphosphonic acid
-
-
linalyl diphosphate
-
competitive inhibition, the enantioselective synthase readily distinguishes between (3R)- and (3S)-homolinalyl diphosphates, both of which were more effective inhibitors than is 3-azageranyl diphosphate, the fluorinated analogues prove to be the most potent competitive inhibitors
Methyl-(4-methylpent-3-en-1-yl)vinyl sulfonium perchlorate
-
potency of inhibition increases with increasing substrate concentration. A combination of sulfonium analog and 0.05 mM diphosphate provides synergistic inhibition
Methylenediphosphonic acid
-
-
p-hydroxymercuribenzoate
-
-
Phosphonoformic acid
-
-