5.5.1.8: (+)-bornyl diphosphate synthase
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For detailed information about (+)-bornyl diphosphate synthase, go to the full flat file.
Reaction
Synonyms
(+)-bornyl diphosphate synthase, (+)-Bornylpyrophosphate cyclase, (+)-BPP cyclase, (-)-BPP cyclase, (di)terpene synthase, bornyl diphosphate synthase, bornyl pyrophosphate synthase, bornyl pyrophosphate synthetase, BPPS, BPS, Geranyl pyrophosphate:(+)-bornyl pyrophosphate cyclase, Geranyl pyrophosphate:(-)-bornyl pyrophosphate cyclase, geranyl-diphosphate cyclase, Synthetase, bornyl pyrophosphate, TPS3
ECTree
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Inhibitors
Inhibitors on EC 5.5.1.8 - (+)-bornyl diphosphate synthase
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(3R)-homolinalyl diphosphate
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i.e. 2,6-dimethyl-2-vinyl-5-heptenyl diphosphate
(3S)-homolinalyl diphosphate
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i.e. 2,6-dimethyl-2-vinyl-5-heptenyl diphosphate
3-aza-2,3-dihydrogeranyl diphosphate
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competitive inhibition, the aza-analog of the substrate is bound anomalously, perhaps as a consequence of the positive charge, bond distortion, or hydrogen bonding resulting from the N for C substitution, binding strutcure, overview
linalyl diphosphate
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competitive inhibition, the enantioselective synthase readily distinguishes between (3R)- and (3S)-homolinalyl diphosphates, both of which were more effective inhibitors than is 3-azageranyl diphosphate, the fluorinated analogues prove to be the most potent competitive inhibitors
Methyl-(4-methylpent-3-en-1-yl)vinyl sulfonium perchlorate
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potency of inhibition increases with increasing substrate concentration. A combination of sulfonium analog and 0.05 mM diphosphate provides synergistic inhibition
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about 50% inhibition at 0.01 mM for 20 min
6-cyclopropylidene-(3E)-methyl-hex-2-en-1-yl diphosphate
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about 50% inhibition at 0.01 mM for 20 min
Dimethyl-(4-methylcyclohex-3-en-1-yl)sulfonium iodide
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potency of inhibition increases with increasing substrate concentration. A combination of sulfonium analog and 0.05 mM diphosphate provides synergistic inhibition