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5.5.1.6: chalcone isomerase

This is an abbreviated version!
For detailed information about chalcone isomerase, go to the full flat file.

Word Map on EC 5.5.1.6

Reaction

a chalcone
=
a flavanone

Synonyms

Chalcone isomerase, chalcone isomerase-like protein, Chalcone-flavanone isomerase, CHI, Chi-1, Chi1, CHI1A, CHI1B1, CHI1B2, CHI2, CHI2B1, CHI2B2, Chi3, CHI3A, CHI3A1, CHI3A2, CHI3B, CHI3B1, CHI3C1, CHI3C2, CHI4, CHI4A, CHI4B, CHIL, CHIL1, CHIL2, EFP, Isomerase, chalcone, MpCHI, SlCHI1, taxifolin-isomerizing enzyme, TRANSPARENT TESTA 5 protein, TT5, type IV CHI protein

ECTree

     5 Isomerases
         5.5 Intramolecular lyases
             5.5.1 Intramolecular lyases (only sub-subclass identified to date)
                5.5.1.6 chalcone isomerase

pH Range

pH Range on EC 5.5.1.6 - chalcone isomerase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.4 - 7.6
90% activity
7 - 10
about 55% activity at pH 7.0, 100% activity at pH around 8.0, about 80% activity at pH 9.0, about 40% activity at pH 10.0
additional information
at pH 7.5 reactions of 4,2',4',6'-tetrahydrochalcone and 4,2',4'-trihydrochalcone and 2',4'-dihydroxychalcone are 90% diffusion controlled, whereas cyclization of 4,2'-dihydroxychalcone is limited by a chemical step that likely reflects the higher pKa of the 2'-hydroxyl group. At pH 6.0 the reactions with 4,2',4',6'-tetrahydrochalcone and 4,2',4'-trihydroxychalcone are 50% diffusion limited, whereas the reactions of 2',4'-dihydroxychalcone and 4,2'-dihydroxychalcone are limited by chemical steps