5.5.1.4: inositol-3-phosphate synthase
This is an abbreviated version!
For detailed information about inositol-3-phosphate synthase, go to the full flat file.
Word Map on EC 5.5.1.4
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5.5.1.4
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nucleation
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neuroblast
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phytic
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ice-nucleating
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monophosphatase
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cloud
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halophytic
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inositol-containing
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cyclitols
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phytate
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supercooled
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galactinol
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hexakisphosphate
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radiative
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2-kinase
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impase
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medicine
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pharmacology
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biotechnology
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synthesis
- 5.5.1.4
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nucleation
-
neuroblast
-
phytic
-
ice-nucleating
-
monophosphatase
-
cloud
-
halophytic
-
inositol-containing
-
cyclitols
- phytate
-
supercooled
- galactinol
-
hexakisphosphate
-
radiative
-
2-kinase
- impase
- medicine
- pharmacology
- biotechnology
- synthesis
Reaction
Synonyms
1D-myo-inositol 3-phosphate synthase, 1L-myo-Inositol-1-phosphate synthase, AtMIPS1, AtMIPS2-1, AtMIPS3, CaMIPS1, CaMIPS2, D-Glucose 6-phosphate cycloaldolase, D-Glucose 6-phosphate-1L-myoinositol 1-phosphate cyclase, D-Glucose 6-phosphate-1L-myoinositol 1-phosphate cycloaldolase, D-Glucose 6-phosphate-L-myo-inositol 1-phosphate cyclase, D-Glucose-6-phosphate,L-myo-inositol-1-phosphate cycloaldolase, D-myo-inositol-3-phosphate synthase, Glucocycloaldolase, Glucose 6-phosphate cyclase, Glucose-6-phosphate inositol monophosphate cycloaldolase, INO-1, INO-2, INO1, Ino1p, iNOS, Inositol 1-phosphate synthase, Inositol 1-phosphate synthetase, inositol 3-phosphate synthase, inositol phosphate synthase, inositol-1-phosphate synthase, inositol-3-phosphate synthase, INPS, INPS1, INS (3) P1 synthase, IP synthase, IPS, L-myo-inositol 1-phosphate synthase, L-myo-Inositol 1-phosphate synthetase, L-myo-Inositol-1-phosphate synthase, MI-1-P synthase, MIP synthase, MIPS, MIPS1, MIPS2, myo-D-inositol 3-phosphate synthase, myo-inositol 1-phosphate synthase, myo-inositol 3-phosphate synthase, myo-inositol phosphate synthase, myo-Inositol-1-P synthase, Myo-inositol-1-phosphate synthase, myo-inositol-3-phosphate synthase, OsMIPS1, OsMIPS1-1, OsMIPS1-2, OsMIPS1-3, OsMIPS2, PcINO1, PINO1 protein, PIP synthase, PIPS, RINO1 protein, SaINO1, sll1981, Synthase, myo-inositol 1-phosphate, TaMIPS1, TaMIPS2, tbINO, yMIP synthase, [Ins(3)P1] synthase
ECTree
5.5.1.4 inositol-3-phosphate synthaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 5.5.1.4 - inositol-3-phosphate synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CDP-2,3-di-O-phytanyl-sn-glycerol + 1D-myo-inositol 1-phosphate
archaetidylinositol phosphate + CMP
-
-
-
-
?
2-deoxy-D-glucose 6-phosphate
5-deoxy-L-myo-inositol 1-phosphate
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at 11.5% of the activity relative to D-glucose 6-phosphate
-
-
?
D-2-Deoxy-2-fluoroglucose 6-phosphate
5-Deoxy-5-fluoro-myo-inositol 1-phosphate
-
-
-
?
D-2-Deoxy-2-fluoroglucose 6-phosphate
5-Deoxy-5-fluoro-myo-inositol 1-phosphate
-
at 0.2% of the activity relative to D-glucose 6-phosphate
-
-
?
D-glucose 6-phosphate
1D-inositol 3-phosphate
-
key enzyme in inositol biosynthesis, rate-limiting step
-
?
D-glucose 6-phosphate
1D-inositol 3-phosphate
-
key enzyme in inositol biosynthesis
-
?
D-glucose 6-phosphate
1D-inositol 3-phosphate
-
the enzyme catalyzes critical steps in inositol biosynthesis
-
?
D-glucose 6-phosphate
1D-inositol 3-phosphate
-
the enzyme catalyzes the first and rate-limiting step in biosynthesis of inositol-containg compounds
-
?
D-glucose 6-phosphate
1D-myo-inositol 3-phosphate
-
class II aldolase
-
?
D-glucose 6-phosphate
1D-myo-inositol 3-phosphate
-
rate-limiting step for de novo inositol biosynthesis
-
?
D-glucose 6-phosphate
1D-myo-inositol 3-phosphate
-
the enzyme is involved in phospholipid biosynthesis and is the key enzyme in regulation of the pathway catalyzing the rate limiting step, overview
-
-
?
D-glucose 6-phosphate
1D-myo-inositol 3-phosphate
-
reaction includes 3 partial reactions with enzyme-bound intermediates, dependent on NAD+
-
-
?
D-glucose 6-phosphate
1D-myo-inositol 3-phosphate
-
the enzyme is involved in phospholipid biosynthesis and is the key enzyme in regulation of the pathway catalyzing the rate limiting step, overview
-
-
?
D-glucose 6-phosphate
1D-myo-inositol 3-phosphate
-
reaction includes 3 partial reactions with enzyme-bound intermediates, dependent on NAD+
-
-
?
D-glucose 6-phosphate
1D-myo-inositol 3-phosphate
-
the enzyme is involved in phospholipid biosynthesis and is the key enzyme in regulation of the pathway catalyzing the rate limiting step, overview
-
-
?
D-glucose 6-phosphate
1D-myo-inositol 3-phosphate
-
reaction includes 3 partial reactions with enzyme-bound intermediates, dependent on NAD+
-
-
?
D-glucose 6-phosphate
1L-myo-inositol 1-phosphate
-
-
-
-
?
D-glucose 6-phosphate
1L-myo-inositol 1-phosphate
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first and rate-limiting step in biosynthesis of all inositol-conatining compounds
-
-
?
D-glucose 6-phosphate
1L-myo-inositol 1-phosphate
-
determination of the catalytic reaction mechanism
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
key enzyme in myo-inositol biosynthetic pathway
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
first step in de novo biosynthesis of myo-inositol
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the key enzyme in the biosynthesis of myo-inositol, and the derivatives of myo-inositol like phytic acid and the inositol phosphatides
-
-
?
D-Glucose 6-phosphate
?
-
functional role of the myo-inositol oxidation pathway during in vivo conversion of glucose into galactosyluronic residues of pectin in germinating lilly pollen
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-Glucose 6-phosphate
?
-
the enzyme catalyzes the first committed step in the production of all inositol containing compounds, including phospholipids
-
-
?
D-glucose 6-phosphate
D-myo-inositol 3-phosphate
-
assay at pH 7.5, 37°C
-
-
?
D-Glucose 6-phosphate
L-myo-Inositol 1-phosphate
-
-
-
-
?
D-Glucose 6-phosphate
L-myo-Inositol 1-phosphate
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first step in the biosynthesis of the unusual osmolyte di-myo-inositol-1,1'-phosphate
-
-
?
D-Glucose 6-phosphate
L-myo-Inositol 1-phosphate
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reaction mechanism involves 3 reaction steps: 1. oxidation by NAD+, 2. condensation to a cyclic molecule, 3. reduction by NADH
-
-
?
D-Glucose 6-phosphate
L-myo-Inositol 1-phosphate
-
absolute specificity for
-
?
D-Glucose 6-phosphate
L-myo-Inositol 1-phosphate
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key enzyme in phytate biosynthesis, a phosphate-rich storage molecule
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-
?
D-Glucose 6-phosphate
L-myo-Inositol 1-phosphate
-
reaction mechanism involves 3 reaction steps: 1. oxidation by NAD+, 2. condensation to a cyclic molecule, 3. reduction by NADH
-
-
?
D-Glucose 6-phosphate
L-myo-Inositol 1-phosphate
-
no reversibility of the overall reaction is found
-
?
D-Glucose 6-phosphate
L-myo-Inositol 1-phosphate
-
at least 5-fold preference for the beta-anomer
-
?
D-Glucose 6-phosphate
L-myo-Inositol 1-phosphate
-
absolute specificity for
-
?
D-Glucose 6-phosphate
L-myo-Inositol 1-phosphate
-
absolute specificity for
-
?
D-Glucose 6-phosphate
L-myo-Inositol 1-phosphate
-
first and rate-limiting step in inositol biosynthesis followed by L-myo-inositol 1-phosphate dephosphorylation catalyzed by a Mg2+-dependent inositol 1-phosphatase, EC 3.1.3.25
-
-
?
D-Glucose 6-phosphate
L-myo-Inositol 1-phosphate
-
important in myo-inositol level regulation
-
-
?
D-Glucose 6-phosphate
L-myo-Inositol 1-phosphate
-
absolute specificity for
-
?
D-Mannose 6-phosphate
myo-Inositol 1-phosphate
-
at 11.5% of the activity relative to D-glucose 6-phosphate
-
-
?
additional information
?
-
-
development of a continuous spectrophotometric method for measuring MIPS activity using a coupled assay that allows the rapid characterization of MIPS in a multiwell plate format, method validation, overview
-
-
?
additional information
?
-
-
inositol phosphates are involved in several signal transduction pathways
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-
?
additional information
?
-
-
inositol phosphates are involved in several signal transduction pathways
-
-
?
additional information
?
-
-
after removal of tightly bound NAD+ the enzyme catalyzes the reduction of 5-keto-D-glucitol 6-phosphate and 5-keto-D-glucose 6-phosphate by NADH to give glucitol 6-phosphate and glucose 6-phosphate respectively
-
-
?
additional information
?
-
-
inositol phosphates are involved in several signal transduction pathways
-
-
?
