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(1R,2R)-4-methylcyclohex-4-ene-1,2-dicarboxylic acid
ZINC04728953
(1R,2S,3S,6R)-3,4-dimethyl-6-(2-methylprop-1-en-1-yl)cyclohex-4-ene-1,2-dicarboxylic acid
ZINC04023366
(1R,6S)-bicyclo[4.1.0]heptane-7,7-dicarboxylic acid
ZINC03852384
(2R)-2-benzylbutanedioic acid
ZINC00291743
(2R)-2-pentylbutanedioic acid
ZINC03033114
(2R,5R)-2-ethenyl-5,6-dihydroxy-2,6-dimethylheptanoic acid
ZINC35464863
(2R,5R)-2-methyl-5-(propan-2-yl)hexanedioic acid
ZINC39738114
(2R,5S)-2-ethenyl-5,6-dihydroxy-2,6-dimethylheptanoic acid
ZINC35464866
(2S)-2,3-diphenylpropanoic acid
ZINC00164149
(2S)-2-(prop-2-yn-1-yl)heptanoic acid
-
(2S)-2-[(5R)-2,5,6-trimethylcyclohepta-1,6-dien-1-yl]pentanedioic acid
ZINC72320447
(2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid
ZINC38141759
(2S,5R)-2-methyl-5-(propan-2-yl)hexanedioic acid
ZINC39738116
(2S,5S)-2-ethenyl-5,6-dihydroxy-2,6-dimethylheptanoic acid
ZINC35464860
(2S,5S)-2-methyl-5-(propan-2-yl)hexanedioic acid
ZINC39738117
(3S)-3-(furan-2-yl)-6-methylheptanoic acid
ZINC02120167
(4S)-4-acetylheptanoic acid
ZINC02470134
1,5-Anhydro-D-glucitol 6-phosphate
-
-
1-Deoxy-1-(phosphonomethyl)myo-2-inosose
-
competitive
2,2,5,7-tetramethyl-1-oxo-2,3-dihydro-1H-indene-4-carboxylic acid
ZINC00137063
2,4-dihydroxy-6-methylbenzoic acid
ZINC00901157
2-(2-methyl-1H-pyrrol-1-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid
ZINC03844222
2-benzyl-2-hydroxy-3-phenylpropanoic acid
ZINC03844661
2-benzyl-2-methylbutanedioic acid
ZINC03844125
2-Deoxy-2-fluoroglucose 6-phosphate
2-deoxy-D-glucitol 6-(E)-vinylhomophosphonate
-
binding structure, interaction with active site residues, overview
2-Deoxy-D-glucitol 6-phosphate
-
-
2-deoxy-D-glucose 6-phosphate
2-deoxy-glucitol-6-phosphate
-
the inhibitor induces folding of the catalytic domain
2-Deoxy-myo-inositol 1-phosphate
-
competitive
5-methyl-4-phenyl-2-(1H-pyrrol-1-yl)thiophene-3-carboxylic acid
ZINC03844214
choline
-
slight inhibition
D-gluconate 6-phosphate
-
-
D-glucose 6-phosphate
-
the beta-anomer is preferred as substrate, the alpha-anomer is an inhibitor
D-mannitol 6-phosphate
-
-
D-sorbitol 6-phosphate
-
-
dihydroxyacetone phosphate
-
-
diphosphate
-
inhibition occurs only in the presence of NH4+. Inhibition is pH-dependent. The inhibition of enzyme activity by diphosphate, at pH 7.7, is reversed in decreasing order of effectiveness by Mn2+, Fe3+, Mg2+, Co2+, Cu2+, Ca2+, Ba2+ and Zn2+
Endogeneous inhibitor from latex serum
-
-
-
methyl[(4-methylphenyl)methyl]propanedioic acid
ZINC03848645
Mg2+
-
inhibitory only at nonphysiological concentrations
myo-2-Inosose 1-phosphate
N-[4-[(dihydroxyamino)sulfanyl]phenyl]-2-propylpentanamide
-
NaBH4
-
partial inactivation in presence of NAD+. No inactivation in absence of NAD+
p-Substituted mercuribenzoate
-
1 mM, 93% inhibition in presence of 1 mM NADH
phosphate
the enzyme activity is almost completely abolished at 125 mM
pyridoxal 5'-phosphate
-
-
sodium hexametaphosphate
the enzyme activity is almost completely abolished at 20 mM
Trinitrobenzene sulphonate
-
-
valnoctamide
-
valproate derivative with anticonvulsant effect. Drastic inhibition of enzyme at 1 mM in crude brain homogenate, competitive
valrocemide
-
valproate derivative with anticonvulsant effect. Drastic inhibition of enzyme at 1 mM in crude brain homogenate
(NH4)2SO4
-
-
2-Deoxy-2-fluoroglucose 6-phosphate
-
-
2-Deoxy-2-fluoroglucose 6-phosphate
-
competitive
2-deoxy-D-glucose 6-phosphate
-
-
2-deoxy-D-glucose 6-phosphate
-
competitive
2-deoxy-D-glucose 6-phosphate
-
-
2-deoxy-D-glucose 6-phosphate
-
-
2-deoxy-D-glucose 6-phosphate
-
-
2-deoxy-D-glucose 6-phosphate
-
-
Cd2+
-
-
Cu2+
-
-
Cu2+
Gleichenia glauca
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-galactose 6-phosphate
-
-
D-galactose 6-phosphate
-
-
D-galactose 6-phosphate
-
-
D-galactose 6-phosphate
-
-
D-mannose 6-phosphate
-
-
D-mannose 6-phosphate
-
competitive
D-mannose 6-phosphate
-
-
EDTA
-
0.002 mM, 50% inhibition
EDTA
-
reactivation by some divalent cations
EDTA
-
reactivation by Mn2+
FeCl2
-
-
glucitol 6-phosphate
-
-
Hg2+
Gleichenia glauca
-
-
Inositol
-
4 mM
Inositol
-
feedback/product inhibition by inhibition of INO1 gene transcription, acts as a metabolic sensor
K+
-
concentration-dependent inhibition up to 5 mM
K+
-
5 mM, 10-15% inhibition
K+
-
concentration-dependent inhibition up to 5 mM
Li+
-
LiCl
Li+
-
14 mM, 50% inhibition in absence of NH4+. Only 10% inhibition in presence of 14 mM NH4+
lithium
-
-
mannitol
-
4 mM
Mn2+
-
inhibitory only at nonphysiological concentrations
myo-2-Inosose 1-phosphate
-
competitive
myo-2-Inosose 1-phosphate
-
competitive
Na+
-
153 mM, 78% inhibition
Na+
-
1 mM and above; chloroplastic and cytosolic enzyme
Na+
-
1 mM and above; chloroplastic enzyme
NEM
-
0.5-2 mM
NEM
-
protection by D-glucose 6-phosphate in presence of NAD+
NH4HCO3
-
-
PbCl2
-
-
PCMB
-
0.5-2 mM
PCMB
-
protection by D-glucose 6-phosphate in presence of NAD+
sorbitol
-
4 mM
Valproate
-
slight inhibition
Valproate
-
noncompetitive, specific, only in vivo, e.g. in brain post mortem, no inhibition of the purified rcombinant enzyme in vitro
Zn2+
-
-
Zn2+
Gleichenia glauca
-
-
Zn2+
-
1 mM, 5fold decrease in activity
additional information
-
not inhibited by up to 50 mM D-glucose
-
additional information
not inhibited by up to 50 mM D-glucose
-