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5.5.1.4: inositol-3-phosphate synthase

This is an abbreviated version!
For detailed information about inositol-3-phosphate synthase, go to the full flat file.

Word Map on EC 5.5.1.4

Reaction

D-glucose 6-phosphate
=
1D-myo-inositol 3-phosphate

Synonyms

1D-myo-inositol 3-phosphate synthase, 1L-myo-Inositol-1-phosphate synthase, AtMIPS1, AtMIPS2-1, AtMIPS3, CaMIPS1, CaMIPS2, D-Glucose 6-phosphate cycloaldolase, D-Glucose 6-phosphate-1L-myoinositol 1-phosphate cyclase, D-Glucose 6-phosphate-1L-myoinositol 1-phosphate cycloaldolase, D-Glucose 6-phosphate-L-myo-inositol 1-phosphate cyclase, D-Glucose-6-phosphate,L-myo-inositol-1-phosphate cycloaldolase, D-myo-inositol-3-phosphate synthase, Glucocycloaldolase, Glucose 6-phosphate cyclase, Glucose-6-phosphate inositol monophosphate cycloaldolase, INO-1, INO-2, INO1, Ino1p, iNOS, Inositol 1-phosphate synthase, Inositol 1-phosphate synthetase, inositol 3-phosphate synthase, inositol phosphate synthase, inositol-1-phosphate synthase, inositol-3-phosphate synthase, INPS, INPS1, INS (3) P1 synthase, IP synthase, IPS, L-myo-inositol 1-phosphate synthase, L-myo-Inositol 1-phosphate synthetase, L-myo-Inositol-1-phosphate synthase, MI-1-P synthase, MIP synthase, MIPS, MIPS1, MIPS2, myo-D-inositol 3-phosphate synthase, myo-inositol 1-phosphate synthase, myo-inositol 3-phosphate synthase, myo-inositol phosphate synthase, myo-Inositol-1-P synthase, Myo-inositol-1-phosphate synthase, myo-inositol-3-phosphate synthase, OsMIPS1, OsMIPS1-1, OsMIPS1-2, OsMIPS1-3, OsMIPS2, PcINO1, PINO1 protein, PIP synthase, PIPS, RINO1 protein, SaINO1, sll1981, Synthase, myo-inositol 1-phosphate, TaMIPS1, TaMIPS2, tbINO, yMIP synthase, [Ins(3)P1] synthase

ECTree

     5 Isomerases
         5.5 Intramolecular lyases
             5.5.1 Intramolecular lyases (only sub-subclass identified to date)
                5.5.1.4 inositol-3-phosphate synthase

Inhibitors

Inhibitors on EC 5.5.1.4 - inositol-3-phosphate synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1R,2R)-4-methylcyclohex-4-ene-1,2-dicarboxylic acid
ZINC04728953
(1R,2S,3S,6R)-3,4-dimethyl-6-(2-methylprop-1-en-1-yl)cyclohex-4-ene-1,2-dicarboxylic acid
ZINC04023366
(1R,6S)-bicyclo[4.1.0]heptane-7,7-dicarboxylic acid
ZINC03852384
(2R)-2-benzylbutanedioic acid
ZINC00291743
(2R)-2-pentylbutanedioic acid
ZINC03033114
(2R,5R)-2-ethenyl-5,6-dihydroxy-2,6-dimethylheptanoic acid
ZINC35464863
(2R,5R)-2-methyl-5-(propan-2-yl)hexanedioic acid
ZINC39738114
(2R,5S)-2-ethenyl-5,6-dihydroxy-2,6-dimethylheptanoic acid
ZINC35464866
(2S)-2,3-diphenylpropanoic acid
ZINC00164149
(2S)-2-(prop-2-yn-1-yl)heptanoic acid
-
(2S)-2-[(5R)-2,5,6-trimethylcyclohepta-1,6-dien-1-yl]pentanedioic acid
ZINC72320447
(2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid
ZINC38141759
(2S,5R)-2-methyl-5-(propan-2-yl)hexanedioic acid
ZINC39738116
(2S,5S)-2-ethenyl-5,6-dihydroxy-2,6-dimethylheptanoic acid
ZINC35464860
(2S,5S)-2-methyl-5-(propan-2-yl)hexanedioic acid
ZINC39738117
(3S)-3-(furan-2-yl)-6-methylheptanoic acid
ZINC02120167
(4S)-4-acetylheptanoic acid
ZINC02470134
(NH4)2SO4
1,5-Anhydro-D-glucitol 6-phosphate
-
-
1-Deoxy-1-(phosphonomethyl)myo-2-inosose
-
competitive
2,2,5,7-tetramethyl-1-oxo-2,3-dihydro-1H-indene-4-carboxylic acid
ZINC00137063
2,4-dihydroxy-6-methylbenzoic acid
ZINC00901157
2-(2-methyl-1H-pyrrol-1-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid
ZINC03844222
2-benzyl-2-hydroxy-3-phenylpropanoic acid
ZINC03844661
2-benzyl-2-methylbutanedioic acid
ZINC03844125
2-Deoxy-2-fluoroglucose 6-phosphate
2-deoxy-D-glucitol
-
-
2-deoxy-D-glucitol 6-(E)-vinylhomophosphonate
-
binding structure, interaction with active site residues, overview
2-Deoxy-D-glucitol 6-phosphate
-
-
2-deoxy-D-glucose 6-phosphate
2-deoxy-glucitol-6-phosphate
-
the inhibitor induces folding of the catalytic domain
2-Deoxy-myo-inositol 1-phosphate
-
competitive
5-methyl-4-phenyl-2-(1H-pyrrol-1-yl)thiophene-3-carboxylic acid
ZINC03844214
choline
-
slight inhibition
D-Allose 6-phosphate
-
-
D-fructose 6-phosphate
D-galactose 6-phosphate
D-gluconate 6-phosphate
-
-
D-glucose 6-phosphate
-
the beta-anomer is preferred as substrate, the alpha-anomer is an inhibitor
D-mannitol 6-phosphate
-
-
D-mannose 6-phosphate
D-sorbitol 6-phosphate
-
-
dihydroxyacetone phosphate
-
-
diphosphate
-
inhibition occurs only in the presence of NH4+. Inhibition is pH-dependent. The inhibition of enzyme activity by diphosphate, at pH 7.7, is reversed in decreasing order of effectiveness by Mn2+, Fe3+, Mg2+, Co2+, Cu2+, Ca2+, Ba2+ and Zn2+
Endogeneous inhibitor from latex serum
-
-
-
FeCl2
glucitol 6-phosphate
Inositol
lithium
mannitol
methyl[(4-methylphenyl)methyl]propanedioic acid
ZINC03848645
Mg2+
-
inhibitory only at nonphysiological concentrations
myo-2-Inosose 1-phosphate
N-[4-[(dihydroxyamino)sulfanyl]phenyl]-2-propylpentanamide
-
NaBH4
-
partial inactivation in presence of NAD+. No inactivation in absence of NAD+
NH4HCO3
p-Substituted mercuribenzoate
-
1 mM, 93% inhibition in presence of 1 mM NADH
PbCl2
phosphate
the enzyme activity is almost completely abolished at 125 mM
pyridoxal 5'-phosphate
-
-
sodium hexametaphosphate
the enzyme activity is almost completely abolished at 20 mM
sorbitol
Trinitrobenzene sulphonate
-
-
valnoctamide
-
valproate derivative with anticonvulsant effect. Drastic inhibition of enzyme at 1 mM in crude brain homogenate, competitive
Valproate
valrocemide
-
valproate derivative with anticonvulsant effect. Drastic inhibition of enzyme at 1 mM in crude brain homogenate
additional information
-