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malfunction
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loss in MIPS1 results in smaller plants with curly leaves and spontaneous production of lesions
malfunction
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the inositol 3-phosphate synthase-deficient mutant is not virulent in mice and loses viability in macrophages
malfunction
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the inositol 3-phosphate synthase-deficient mutant is not virulent in mice and loses viability in macrophages
malfunction
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the inositol 3-phosphate synthase-deficient mutant is not virulent in mice and loses viability in macrophages
malfunction
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the inositol 3-phosphate synthase-deficient mutant is not virulent in mice and loses viability in macrophages
malfunction
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the inositol 3-phosphate synthase-deficient mutant is virulent in mice as the wild type
malfunction
endomembrane function in embryo cells is impaired in the mips1mips3 double mutant. Mips1 mips2 double mutant and the mips1 mips2 mips3 triple mutant phenotypes, overview
malfunction
null mips1 mutants are defective in embryogenesis, cotyledon venation patterning, root growth, and root cap development. The mutant roots are also agravitropic and have reduced basipetal auxin transport. mips1 mutants have significantly reduced levels of major phosphatidylinositols and exhibit much slower rates of endocytosis, as well as altered PIN2 trafficking, phenotype, detailed overview
malfunction
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overexpression in Arabidopsis provides significantly improved tolerance to salt stress during germination and seedling growth and development. Transgenics retain more chlorophyll and carotenoid by protecting the photosystem II. The low level of stress-induced cellular damage in the transgenics is clearly evident by lower accumulation of proline in comparison to wild-tpye
malfunction
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seed-specific silencing of MIPS in transgenic rice plants leads to substantial reduction in levels of phytic acid along with an increase in phosphate content. Low phytate seeds have an undesirable diminution in levels of myo-inositol and ascorbate possibly leading to sensitiveness of seeds to abscisic acid during germination
malfunction
transgenic expression of CaMIPS2 in Arabidopsis enhances tolerance to salinity and dehydration stress
malfunction
transgenic expression of isoenzyme CaMIPS1 in Arabidopsis improves tolerance to salinity and dehydration stress but not as strong as transgenic expression of isoenzyme CaMIPS2
malfunction
enzyme loss causes a pleiotropic phenotype, triggers inositol depletion and results in an inositol auxotrophy
malfunction
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null mips1 mutants are defective in embryogenesis, cotyledon venation patterning, root growth, and root cap development. The mutant roots are also agravitropic and have reduced basipetal auxin transport. mips1 mutants have significantly reduced levels of major phosphatidylinositols and exhibit much slower rates of endocytosis, as well as altered PIN2 trafficking, phenotype, detailed overview
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metabolism
MIPS catalyzes the rate-limiting step in de novo synthesis of myo-inositol
metabolism
myo-inositol-1-phosphate synthase is a conserved enzyme that catalyzes the first committed and rate-limiting step in inositol biosynthesis
metabolism
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the reaction catalyzed by MIPS is the first step in the biosynthesis of inositol and inositol-containing molecules that serve important roles in both eukaryotes and prokaryotes
metabolism
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myo-inositol-1-phosphate synthase is a conserved enzyme that catalyzes the first committed and rate-limiting step in inositol biosynthesis
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physiological function
isoform gammac negatively modulates alpha isoform activity, possibly by competing for NAD+, when the gammac isoform is preincubated with NAD+, prior to incubation with the alpha isoform, the decrease is quite pronounced with enzyme activity falling to about 63% at the end of 1 h and to about 40% at the end of 3 h
physiological function
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isoform MIPS1, but not MIPS2 or MIPS3, is required for seed development, for physiological responses to salt and abscisic acid, and to suppress cell death
physiological function
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MIPS is a pivotal biosynthetic enzyme in the myo-inositol pathway, including the synthesis of phytic acid
physiological function
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MIPS is a pivotal biosynthetic enzyme in the myo-inositol pathway, including the synthesis of phytic acid
physiological function
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MIPS is a pivotal biosynthetic enzyme in the myo-inositol pathway, including the synthesis of phytic acid
physiological function
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MIPS is a pivotal biosynthetic enzyme in the myo-inositol pathway, including the synthesis of phytic acid
physiological function
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MIPS is a pivotal biosynthetic enzyme in the myo-inositol pathway, including the synthesis of phytic acid
physiological function
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MIPS is a pivotal biosynthetic enzyme in the myo-inositol pathway, including the synthesis of phytic acid
physiological function
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MIPS is a pivotal biosynthetic enzyme in the myo-inositol pathway, including the synthesis of phytic acid
physiological function
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MIPS is a pivotal biosynthetic enzyme in the myo-inositol pathway, including the synthesis of phytic acid
physiological function
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MIPS is a pivotal biosynthetic enzyme in the myo-inositol pathway, including the synthesis of phytic acid
physiological function
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MIPS is a pivotal biosynthetic enzyme in the myo-inositol pathway, including the synthesis of phytic acid
physiological function
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MIPS is a pivotal biosynthetic enzyme in the myo-inositol pathway, including the synthesis of phytic acid
physiological function
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MIPS is a pivotal biosynthetic enzyme in the myo-inositol pathway, including the synthesis of phytic acid
physiological function
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MIPS is a pivotal biosynthetic enzyme in the myo-inositol pathway, including the synthesis of phytic acid
physiological function
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MIPS is a pivotal biosynthetic enzyme in the myo-inositol pathway, including the synthesis of phytic acid
physiological function
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MIPS is a pivotal biosynthetic enzyme in the myo-inositol pathway, including the synthesis of phytic acid
physiological function
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MIPS is a pivotal biosynthetic enzyme in the myo-inositol pathway, including the synthesis of phytic acid
physiological function
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MIPS is a pivotal biosynthetic enzyme in the myo-inositol pathway, including the synthesis of phytic acid
physiological function
MIPS plays an important role in the defensive mechanisms of Ricinus communis against drought stress
physiological function
MIPS1 is required for multiple developmental processes. It is critical for maintaining phosphatidylinositol levels and affects pattern formation in plants likely through regulation of auxin distribution. MIPS1 is required for embryo development and vascular patterning
physiological function
isoenzyme CaMIPS1 and CaMIPS2 are successfully complemented and shown to repair the defect of seedling growth and altered seed phenotype of Atmips1 mutant
physiological function
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expression of myo-inositol 3-phosphate synthase confers salt tolerance in rice
physiological function
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MIPS1 is required for multiple developmental processes. It is critical for maintaining phosphatidylinositol levels and affects pattern formation in plants likely through regulation of auxin distribution. MIPS1 is required for embryo development and vascular patterning
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