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5.5.1.2: 3-carboxy-cis,cis-muconate cycloisomerase

This is an abbreviated version!
For detailed information about 3-carboxy-cis,cis-muconate cycloisomerase, go to the full flat file.

Word Map on EC 5.5.1.2

Reaction

cis,cis-butadiene-1,2,4-tricarboxylate
=
2-carboxy-2,5-dihydro-5-oxofuran-2-acetate

Synonyms

2-chloromuconate cycloisomerase, 3-Carboxy-cis,cis-muconate lactonizing enzyme, 3-Carboxy-cis-cis-muconate cycloisomerase, 3-carboxymuconate lactonizing enzyme, 3-Carboxymuconolactone hydrolase, beta-Carboxy-cis,cis-muconate lactonizing enzyme, beta-Carboxymuconate lactonizing enzyme, CMLE, Isomerase, 3-carboxy-cis, cis-muconate cyclo-, MLE, PA4204 protein, PpCMLE, PpgL

ECTree

     5 Isomerases
         5.5 Intramolecular lyases
             5.5.1 Intramolecular lyases (only sub-subclass identified to date)
                5.5.1.2 3-carboxy-cis,cis-muconate cycloisomerase

Inhibitors

Inhibitors on EC 5.5.1.2 - 3-carboxy-cis,cis-muconate cycloisomerase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
citrate
noncompetitive, localization of binding pocket on the enzyme outside the active site
Dicarboxylic acids
-
saturated dicarboxylic acids with the exception of oxalate, are less inhibitory as the molecular weight increases. Compounds with two cis-carboxyl groups are much more inhibitory than the corresponding trans-isomers
EDTA
-
the enzyme is partially sensitive to EDTA
isocitrate
noncompetitive, localization of binding pocket on the enzyme outside the active site
phosphate
-
-
Tricarboxylic acids
-
-
-
additional information
-