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5.5.1.16: halimadienyl-diphosphate synthase

This is an abbreviated version!
For detailed information about halimadienyl-diphosphate synthase, go to the full flat file.

Reaction

geranylgeranyl diphosphate
=
tuberculosinyl diphosphate

Synonyms

CPS4:H501, HPS

ECTree

     5 Isomerases
         5.5 Intramolecular lyases
             5.5.1 Intramolecular lyases (only sub-subclass identified to date)
                5.5.1.16 halimadienyl-diphosphate synthase

Systematic Name

Systematic Name on EC 5.5.1.16 - halimadienyl-diphosphate synthase

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SYSTEMATIC NAME
IUBMB Comments
halima-5,13-dien-15-yl-diphosphate lyase (decyclizing)
Requires Mg2+ for activity. This enzyme is found in pathogenic prokaryotes such as Mycobacterium tuberculosis but not in non-pathogens such as Mycobacterium smegmatis so may play a role in pathogenicity. The product of the reaction is subsequently dephosphorylated yielding tuberculosinol (halima-5,13-dien-15-ol).