5.5.1.16: halimadienyl-diphosphate synthase

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For detailed information about halimadienyl-diphosphate synthase, go to the full flat file.

Reaction

Synonyms

CPS4:H501, HPS

ECTree

     5 Isomerases

         5.5 Intramolecular lyases

             5.5.1 Intramolecular lyases (only sub-subclass identified to date)

                5.5.1.16 halimadienyl-diphosphate synthase

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Results	in table
5	AA Sequence
2	Cloned(Commentary)
2	General Information
2	IC50 Value
4	Inhibitors
1	Ki Value [mM]
1	KM Value [mM]
2	Metals/Ions
1	Natural Substrates/ Products (Substrates)
195	Organism
1	Pathway
1	Purification (Commentary)
1	Reaction
5	Reference
1	Storage Stability
5	Substrates and Products (Substrate)
3	Synonyms
1	Systematic Name
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 5.5.1.16 - halimadienyl-diphosphate synthase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

(E,E,E)-geranylgeranyl diphosphate

Mycobacterium tuberculosis

-

substrate inhibition

704527

15-aza-14,15-dihydrogeranylgeranyl diphosphate

Mycobacterium tuberculosis

-

-

704527

15-aza-14,15-dihydrogeranylgeranyl thiolodiphosphate

Mycobacterium tuberculosis

-

-

704527

Mg2+

Mycobacterium tuberculosis

-

the enzyme displays a rapid loss of activity as the Mg2+ concentration is raised above 0.1 mM

704527