5.5.1.15: terpentedienyl-diphosphate synthase

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For detailed information about terpentedienyl-diphosphate synthase, go to the full flat file.

Reaction

Synonyms

Cyc1

ECTree

     5 Isomerases

         5.5 Intramolecular lyases

             5.5.1 Intramolecular lyases (only sub-subclass identified to date)

                5.5.1.15 terpentedienyl-diphosphate synthase

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Results	in table
1	Activating Compound
7	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
2	Inhibitors
1	KM Value [mM]
2	Metals/Ions
1	Molecular Weight [Da]
5	Organism
4	Pathway
1	pH Optimum
1	Purification (Commentary)
1	Reaction
4	Reference
4	Substrates and Products (Substrate)
1	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 5.5.1.15 - terpentedienyl-diphosphate synthase

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SYSTEMATIC NAME

IUBMB Comments

terpentedienyl-diphosphate lyase (decyclizing)

Requires Mg2+. Contains a DXDD motif, which is a characteristic of diterpene cylases whose reactions are initiated by protonation at the 14,15-double bond of geranylgeranyl diphosphate (GGDP) [2]. The triggering proton is lost at the end of the cyclization reaction [3]. The product of the reaction, terpentedienyl diphosphate, is the substrate for EC 4.2.3.36, terpentetriene synthase and is a precursor of the diterpenoid antibiotic terpentecin.