5.5.1.13: ent-copalyl diphosphate synthase

This is an abbreviated version!
For detailed information about ent-copalyl diphosphate synthase, go to the full flat file.

Word Map on EC 5.5.1.13

5.5.1.13

gibberellin

diterpene

diterpenoids

geranylgeranyl

phytohormone

phytoalexins

ent-cpp

ent-kaurenoic

phytocassanes

e,e,e-geranylgeranyl

oscps4

3-oxidase

ga-deficient

labdane-related

ga1

ditpss

oryzalexins

ga20ox

syn-copalyl

Reaction

Synonyms

copalyl diphosphate synthase/ent-kaurene synthase, copalyl synthase/kaurene synthase, CPS, CPS/KS, CPS1, CPS2, CPS2/Cyc2, CPS3, ent-copalyl/ent-kaurene synthase, ent-copylyl diphosphate synthase/ent-kaurene synthase, ent-CPS, ent-kaurene synthase A, ent-kaurene synthetase A, GfCPS/KS, OsCPS1, OsCPS1ent, OsCPS2ent, OsCyc2

ECTree

5 Isomerases

5.5 Intramolecular lyases

5.5.1 Intramolecular lyases (only sub-subclass identified to date)

5.5.1.13 ent-copalyl diphosphate synthase

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Results	in table
2	Activating Compound
56	AA Sequence
1	CAS Registry Number
30	Cloned(Commentary)
1	Crystallization (Commentary)
31	General Information
13	Inhibitors
8	kcat/KM [mM/s]
12	KM Value [mM]
15	Localization
5	Metals/Ions
10	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
3	Organic Solvent Stability
72	Organism
10	Pathway
5	PDB ID
2	pH Optimum
2	pH Range
27	Protein Variants
17	Purification (Commentary)
4	Reaction
1	Reaction Type
46	Reference
18	Source Tissue
3	Specific Activity [micromol/min/mg]
50	Substrates and Products (Substrate)
2	Subunits
40	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Stability [°C]
12	Turnover Number [1/s]

Engineering

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Engineering on EC 5.5.1.13 - ent-copalyl diphosphate synthase

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D503A

Arabidopsis thaliana

Q38802

the mutant exhibits a 7fold reduction in kcat

729301

E211A

Arabidopsis thaliana

Q38802

the mutation results in a nearly 500fold reduction in kcat

729301

N425A

Arabidopsis thaliana

Q38802

the mutant exhibits a 13fold reduction in kcat

729301

R340A

Arabidopsis thaliana

Q38802

the mutant exhibits an 850fold reduction in kcat

729301

T421A

Arabidopsis thaliana

Q38802

the mutant exhibits a 163fold reduction in kcat (KM is increased 2fold)

729301

T421S

Arabidopsis thaliana

Q38802

the mutant exhibits a 3fold reduction in kcat

729301

D320A

Phaeosphaeria sp.

O13284

the mutation leads to complete enzyme activity

492252

D656A

Phaeosphaeria sp.

O13284

the mutation causes a small reduction in activity

A710C

A710F

A710G

A710L

the substitution changes the ratio of ent-kaurene and 16alpha-hydroxy-entkaurane produced. The production of ent-kaurene is increased to the same level as that of 16alpha-hydroxyent-kaurane

A710M

A710N

A710S

C717A

site-directed mutagenesis, the mutant protein shows the same enzymic activity as wild-type Jungermannia subulata JsCPS/KS

714971

additional information

5 entries