5.5.1.11: dichloromuconate cycloisomerase

This is an abbreviated version!
For detailed information about dichloromuconate cycloisomerase, go to the full flat file.

Reaction

Synonyms

dichloromuconate cycloisomerase, isomerase, dichloromuconate cyclo-

ECTree

     5 Isomerases

         5.5 Intramolecular lyases

             5.5.1 Intramolecular lyases (only sub-subclass identified to date)

                5.5.1.11 dichloromuconate cycloisomerase

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Results	in table
1	CAS Registry Number
1	Cofactor
5	Inhibitors
7	KM Value [mM]
1	Metals/Ions
2	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
52	Organism
4	Pathway
1	pH Optimum
1	pH Range
1	Purification (Commentary)
1	Reaction
1	Reaction Type
4	Reference
4	Source Tissue
3	Specific Activity [micromol/min/mg]
2	Storage Stability
15	Substrates and Products (Substrate)
2	Subunits
2	Synonyms
1	Systematic Name
7	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 5.5.1.11 - dichloromuconate cycloisomerase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2,4-dichloro-cis,cis-muconate

4-carboxymethylene-3-chlorobut-2-en-4-olide + HCl

5 entries

2-chloro-4-methyl-cis,cis-muconate

2-chloro-4-methyl-muconolactone

Cupriavidus necator

-

-

648899

4-carboxymethyl-2-chlorobut-4-methylbut-2-en-4-olide

648899

?

2-Chloro-cis,cis-muconate

?

2 entries

2-Methyl-cis,cis-muconate

?

2 entries

3-chloro-cis,cis-muconate

?

Cupriavidus necator

-

-

648898

-

-

?

3-Methyl-cis,cis-muconate

?

2 entries

cis,cis-Muconate

?

2 entries

2,4-dichloro-cis,cis-muconate

4-carboxymethylene-3-chlorobut-2-en-4-olide + HCl

Cupriavidus necator

-

-

648898

-

648898

?

2,4-dichloro-cis,cis-muconate

4-carboxymethylene-3-chlorobut-2-en-4-olide + HCl

Cupriavidus necator

-

-

648899

The intermediate (2,4-dichloro-5-oxo-2,5-dihydrofuran-2-yl)acetic acid (i.e. 3,5-dichloro-2,5-dihydro-2-oxofuran-5-acetate) is spontanously dehalogenated to 4-carboxymethylene-3-chlorobut-2-en-4-olide (i.e. 2-chlorodienelactone)

-

ir

2,4-dichloro-cis,cis-muconate

4-carboxymethylene-3-chlorobut-2-en-4-olide + HCl

Cupriavidus necator

-

enzyme is involved in 3,5-dichloro-catechol metabolism

648899

The intermediate (2,4-dichloro-5-oxo-2,5-dihydrofuran-2-yl)acetic acid (i.e. 3,5-dichloro-2,5-dihydro-2-oxofuran-5-acetate) is spontanously dehalogenated to 4-carboxymethylene-3-chlorobut-2-en-4-olide (i.e. 2-chlorodienelactone)

648899

ir

2,4-dichloro-cis,cis-muconate

4-carboxymethylene-3-chlorobut-2-en-4-olide + HCl

Cupriavidus necator JMP 134-1

-

-

648899

The intermediate (2,4-dichloro-5-oxo-2,5-dihydrofuran-2-yl)acetic acid (i.e. 3,5-dichloro-2,5-dihydro-2-oxofuran-5-acetate) is spontanously dehalogenated to 4-carboxymethylene-3-chlorobut-2-en-4-olide (i.e. 2-chlorodienelactone)

-

ir

2,4-dichloro-cis,cis-muconate

4-carboxymethylene-3-chlorobut-2-en-4-olide + HCl

Cupriavidus necator JMP 134-1

-

-

648898

-

648898

?

2-Chloro-cis,cis-muconate

?

Cupriavidus necator

-

-

648898

-

-

?

2-Chloro-cis,cis-muconate

?

Cupriavidus necator JMP 134-1

-

-

648898

-

-

?

2-Methyl-cis,cis-muconate

?

Cupriavidus necator

-

-

648898

-

-

?

2-Methyl-cis,cis-muconate

?

Cupriavidus necator JMP 134-1

-

-

648898

-

-

?

3-Methyl-cis,cis-muconate

?

Cupriavidus necator

-

-

648898

-

-

?

3-Methyl-cis,cis-muconate

?

Cupriavidus necator JMP 134-1

-

-

648898

-

-

?

cis,cis-Muconate

?

Cupriavidus necator

-

-

648898

-

-

?

cis,cis-Muconate

?

Cupriavidus necator JMP 134-1

-

-

648898

-

-

?