5.5.1.1: Muconate cycloisomerase
This is an abbreviated version!
For detailed information about Muconate cycloisomerase, go to the full flat file.
Word Map on EC 5.5.1.1
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5.5.1.1
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muconolactone
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beta-ketoadipate
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cycloisomerization
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protoanemonin
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5-chloromuconolactone
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maleylacetate
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2-chloro-cis,cis-muconate
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cutaneum
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cis-dienelactone
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chlorocatechols
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o-succinylbenzoate
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4-chlorophenol
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5.3.3.4
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3-chloro
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4-chlorocatechol
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gerlt
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phenol-degrading
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ortho-cleavage
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trans-dienelactone
- 5.5.1.1
- muconolactone
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beta-ketoadipate
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cycloisomerization
- protoanemonin
- 5-chloromuconolactone
- maleylacetate
- 2-chloro-cis,cis-muconate
- cutaneum
- cis-dienelactone
- chlorocatechols
- o-succinylbenzoate
- 4-chlorophenol
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5.3.3.4
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3-chloro
- 4-chlorocatechol
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gerlt
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phenol-degrading
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ortho-cleavage
- trans-dienelactone
Reaction
Synonyms
(chloro)-muconate cycloisomerase, (chloro)muconate cycloisomerase, 2-chloromuconate cycloisomerase, ADP1, anti-MLE, CatB, cis,cis-Muconate cycloisomerase, cis,cis-muconate lactonizing enzyme, cis,cis-Muconate-lactonizing enzyme, Enzymes, muconate-lactonizing, Isomerase, muconate cyclo-, MC, MC II, MC O, MCI, MCIase, MCIccaB, MLE, MLE-1, MLE-2, MLEI, muconate cycloisomerase, Muconate cycloisomerase I, Muconate lactonizing enzyme, Rho-2-CMCI, syn-MLE, TcMLE
ECTree
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Metals Ions
Metals Ions on EC 5.5.1.1 - Muconate cycloisomerase
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Co2+
Mg2+
Mn2+
additional information
Mg2+
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28% of the activity with Mn2+, enzyme form MC I. 17% of the activity with Mn2+, enzyme form MC II
Mg2+
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Mg2+ binds deep within a non-solvent exposed cavity, coordinated by 2 aspartate and 1 glutamic acid residues, a single water molecule and the substrate, in a distorted octahedral form. The carboxylate of cis,cis-muconate binds across the Mg2+ ion in conformations that display mirror-like symmetry in the two different proteins
Mg2+
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Mg2+ binds deep within a non-solvent exposed cavity, coordinated by 2 aspartate and 1 glutamic acid residues, a single water molecule and the substrate, in a distorted octahedral form. The carboxylate of cis,cis-muconate binds across the Mg2+ ion in conformations that display mirror-like symmetry in the two different proteins
Mn2+
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divalent metal ion required, enzyme contains a single binding site per subunit, Km: 0.003-0.0045 mM
additional information
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the absence of MnCl2 in the reaction medium has no effect on the activity of MCI