5.4.99.5: chorismate mutase
This is an abbreviated version!
For detailed information about chorismate mutase, go to the full flat file.
Word Map on EC 5.4.99.5
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5.4.99.5
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shikimate
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sieve
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monofunctional
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phloem
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l-phenylalanine
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l-tyrosine
-
7-phosphate
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mutases
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t-proteins
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3-deoxy-d-arabino-heptulosonate
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phenylpyruvate
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claisen
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arogenate
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pericyclic
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nonketotic
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hyperglycinemia
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isochorismate
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cyclohexadienyl
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hydroxyphenylpyruvate
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photorespiratory
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preorganization
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drug development
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3-deoxy-d-arabino-heptulosonate-7-phosphate
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meloidogyne
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synthesis
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agriculture
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analysis
- 5.4.99.5
- shikimate
-
sieve
-
monofunctional
- phloem
- l-phenylalanine
- l-tyrosine
- 7-phosphate
- mutases
-
t-proteins
-
3-deoxy-d-arabino-heptulosonate
- phenylpyruvate
-
claisen
- arogenate
-
pericyclic
-
nonketotic
- hyperglycinemia
- isochorismate
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cyclohexadienyl
- hydroxyphenylpyruvate
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photorespiratory
-
preorganization
- drug development
-
3-deoxy-d-arabino-heptulosonate-7-phosphate
- meloidogyne
- synthesis
- agriculture
- analysis
Reaction
Synonyms
105-MtCM, 90-MtCM, AmtCM1, AmtCM2, aro7, AroA, AroH, AroQ, AtCM1, AtCM2, AtCM3, Bacillus subtilis chorismate mutase, Bphy_7813, BsAroH, BsCM, BsCM_2, BTH_I1596, chorismate mutase, chorismate mutase 1, chorismate mutase-prephenate dehydrogenase, Chorismate mutase/prephenate dehydratase, CM, CM type 2, CM-1, CM-prephenate dehydratase, CM-TyrAp, CM/PDT, CM/PDT/PDHG, CM0819, CM1, CM2, EcCM, EcCM-R, MI-CM-1, MI-CM-2, MjCM, MTB chorismate mutase, MTB CM, MtbCM, MtCM, Mutase, chorismate, Mycobacterium tuberculosis chorismate mutase, Mycobacterium tuberculosis H37Rv chorismate mutase, NC30, P protein, P-protein, PheA, PpCM1, PpCM2, Rv0948c, Rv1885c, SmCM, Tparo7, TtCM, y2828, YCM
ECTree
5.4.99.5 chorismate mutaseAdvanced search results
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Substrates Products on EC 5.4.99.5 - chorismate mutase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Chorismate
?
-
catalyzes the first step in the branch of the shikimate pathway which leads to the aromatic amino acids, Phe and Tyr
-
-
?
Chorismate
?
-
the existence of a cytosolic isoenzyme in addition to the plastidic isoenzyme implies that either a cytosolic pathway, partial or complete, for the biosynthesis of Phe and Tyr exists, or that prephenate, originating from chorismate in the cytosol, is utilized for the synthesis of metabolites other than these two aromatic amino acids
-
-
?
Chorismate
?
-
plastidic isoenzyme is elicitor-inducible and pathogen-inducible
-
-
?
Chorismate
?
-
in the biosynthesis of Phe and Tyr, there are two enzymes or enzyme complexes metabolizing chorismate, one leading through prephenate to phenylpyruvate and the other leading through prephenate to 4-hydroxyphenylpyruvate
-
-
?
Chorismate
?
-
in the biosynthesis of Phe and Tyr, there are two enzymes or enzyme complexes metabolizing chorismate, one leading through prephenate to phenylpyruvate and the other leading through prephenate to 4-hydroxyphenylpyruvate
-
-
?
Chorismate
?
-
the first enzyme of the terminal biosynthetic pathway of Phe and Tyr
-
-
?
Chorismate
Prephenate
interactions with charged residues in the active site distort chorismate into a reactive transition state that leads to prephenate
-
-
?
Chorismate
Prephenate
interactions with charged residues in the active site distort chorismate into a reactive transition state that leads to prephenate
-
-
?
Chorismate
Prephenate
the enzyme is involved in aromatic amino acid biosynthesis
-
-
?
Chorismate
Prephenate
Q9Y7B2
enzyme of the first branch point of aromatic amino acid biosynthesis
-
?
Chorismate
Prephenate
biosynthesis of aromatic amino acids
-
?
Chorismate
Prephenate
first committed step in the biosynthesis of the aromatic amino acids tyrosine and phenylalanine in bacteria, fungi and higher plants
-
?
Chorismate
Prephenate
-
shikimate pathway in bacteria, fungi and higher plants that leads to tyrosine and phenylalanine
-
?
Chorismate
Prephenate
Burkholderia thailandensis ATCC 700388 / DSM 13276 / CIP 106301 / E264
-
-
-
?
Chorismate
Prephenate
-
(-)-chorismate. No activity with (+)-chorismate
-
?
Chorismate
Prephenate
biosynthesis of aromatic amino acids
-
?
Chorismate
Prephenate
-
shikimate pathway in bacteria, fungi and higher plants that leads to tyrosine and phenylalanine
-
?
Chorismate
Prephenate
-
(-)-chorismate. No activity with (+)-chorismate
-
?
Chorismate
Prephenate
-
(-)-chorismate. No activity with (+)-chorismate
-
?
Chorismate
Prephenate
-
biosynthesis of aromatic amino acids
-
?
Chorismate
Prephenate
-
-
-
-
?
Chorismate
Prephenate
the enzyme catalyzes the Claisen rearrangement of chorismate to prephenate
-
-
?
Chorismate
Prephenate
the rearrangement of chorismate to prephenate is strongly exergonic and essentially irreversible in nature
-
-
ir
Chorismate
Prephenate
Mycobacterium tuberculosis ATCC 25618 / H37Rv
the rearrangement of chorismate to prephenate is strongly exergonic and essentially irreversible in nature
-
-
ir
Chorismate
Prephenate
the enzyme catalyzes the Claisen rearrangement of chorismate to prephenate
-
-
?
Chorismate
Prephenate
interactions with charged residues in the active site distort chorismate into a reactive transition state that leads to prephenate
-
-
?
Chorismate
Prephenate
biosynthesis of aromatic amino acids
-
?
Chorismate
Prephenate
-
enzyme of the first branch point of aromatic amino acid biosynthesis
-
?
Chorismate
Prephenate
interactions with charged residues in the active site distort chorismate into a reactive transition state that leads to prephenate
-
-
?
Chorismate
Prephenate
biosynthesis of aromatic amino acids
-
?
additional information
?
-
The enzymatic reaction is considered to proceed via a pericyclic transition state
-
-
?
additional information
?
-
-
The enzymatic reaction is considered to proceed via a pericyclic transition state
-
-
?
additional information
?
-
the isozyme encoded by Rv1885c is characterized as a mono-functional chorismate mutase
-
-
?
additional information
?
-
-
the isozyme encoded by Rv1885c is characterized as a mono-functional chorismate mutase
-
-
?
additional information
?
-
Mycobacterium tuberculosis ATCC 25618 / H37Rv
the isozyme encoded by Rv1885c is characterized as a mono-functional chorismate mutase
-
-
?
additional information
?
-
It is possible that an extracellular biosynthetic pathway from chorismate to phenylalanine exists in Mycobacterium smegmatis, even if the function of such putative route is presently obscure
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-
?
additional information
?
-
-
It is possible that an extracellular biosynthetic pathway from chorismate to phenylalanine exists in Mycobacterium smegmatis, even if the function of such putative route is presently obscure
-
-
?
additional information
?
-
-
isochorismate-pyruvate lyase, PchB EC 4.2.99.21, can also perform the chorismate mutase reaction
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-
?
