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5.4.99.47: parkeol synthase

This is an abbreviated version!
For detailed information about parkeol synthase, go to the full flat file.

Word Map on EC 5.4.99.47

Reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene
=
parkeol

Synonyms

2,3-Oxidosqualene cyclase, AK066327, CAS1Ile481Val, cycloartenol synthase 1 mutant I481V, cycloartenol synthase mutant H477N, cycloartenol synthase mutant H477Q, ERG7, ERG7H234Y, lanosterol-synthase mutant T384Y, lanosterol-synthase mutant T384Y/V454I, lanosterol-synthase mutant T384Y/V454L, OSC, OSLC, OsOP, OsOSC7, OSPC, oxidosqualene cyclase 7 mutant N478H/V482I, Oxidosqualene-lanosterol cyclase, oxidosqualene-lanosterol cyclase mutant H234Y, oxidosqualene:lanosterol cyclase, tetracyclic parkeol synthase

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.99 Transferring other groups
                5.4.99.47 parkeol synthase

Substrates Products

Substrates Products on EC 5.4.99.47 - parkeol synthase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(3S)-2,3-epoxy-2,3-dihydrosqualene
orysatinol
show the reaction diagram
(3S)-2,3-epoxy-2,3-dihydrosqualene
parkeol
show the reaction diagram
(3S)-2,3-oxidosqualene
achilleol A + protosta-12,24-dien-3beta-ol + lanosterol + parkeol
show the reaction diagram
-
-
oxidosqualene-lanosterol cyclase mutant H234Y produces a product ratio of 14:26:51:9
-
?
(3S)-2,3-oxidosqualene
cycloartenol + lanosterol + parkeol
show the reaction diagram
-
-
the cycloartenol synthase 1 mutant I481V makes a relative product ratio of 52:26:22
-
?
(3S)-2,3-oxidosqualene
lanosterol + parkeol
show the reaction diagram
-
-
1:1 product ratio
-
?
(3S)-2,3-oxidosqualene
parkeol
show the reaction diagram
(S)-2,3-oxidosqualene
parkeol + cycloartenol + lanosterol
show the reaction diagram
-
-
parkeol is the main product of mutant N478H/V482I
-
?
(S)-2,3-oxidosqualene
parkeol + lanosterol + lanost-24-ene-3beta,9alpha-diol
show the reaction diagram
-
-
lanosterol-synthase mutant T384Y produces 11% parkeol, 79% lanosterol and 10% lanost-24-ene-3beta,9alpha-diol from (S)-2,3-oxidosqualene, lanosterol-synthase mutant T384Y/V4545L produces 60% parkeol, 20% lanosterol and 20% lanost-24-ene-3beta,9alpha-diol from (S)-2,3-oxidosqualene, lanosterol-synthase mutant T384Y/V454I produces 64% parkeol, 13% lanosterol and 23% lanost-24-ene-3beta,9alpha-diol from (S)-2,3-oxidosqualene
-
?
oxidosqualene
lanosterol + parkeol
show the reaction diagram
-
-
mutant H477N produces 88% lanosterol and 12% parkeol, mutant H477Q produces 73% parkeol, 22% lanosterol, and 5% DELTA7-lanosterol
-
?
additional information
?
-