5.4.99.40: alpha-amyrin synthase

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For detailed information about alpha-amyrin synthase, go to the full flat file.

Reaction

Synonyms

2,3-oxidosqualene alpha-amyrin cyclase, alpha amyrin synthase, alpha-amyrin synthase, alpha/beta amyrin synthase, BmOSC, CrAS, MdOSC1, MdOSC3, mixed amyrin synthase, multifunctional OSC, ObAS2, OPSC 1, OSC, OSC1, OSC3, OSCPSM, Oxidosqualene cyclase, oxidosqualene cyclases, PSM, SlTTS1

ECTree

     5 Isomerases

         5.4 Intramolecular transferases

             5.4.99 Transferring other groups

                5.4.99.40 alpha-amyrin synthase

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Results	in table
12	AA Sequence
9	Cloned(Commentary)
2	Expression
6	General Information
2	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
9	Organism
4	Pathway
1	Protein Variants
1	Purification (Commentary)
1	Reaction
7	Reference
13	Source Tissue
11	Substrates and Products (Substrate)
30	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 5.4.99.40 - alpha-amyrin synthase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(3S)-2,3-epoxy-2,3-dihydrosqualene

alpha-amyrin

4 entries

(S)-2,3-oxidosqualene

alpha-amyrin

Malus domestica

C7SCX0, C7SCX2

via dammarenyl cation

748772

-

-

r

(S)-2,3-oxidosqualene

alpha-amyrin + beta-amyrin

Malus domestica

C7SCX0

-

711990

OSC1 produces a 5:1 ratio of alpha-amyrin to beta-amyrin

-

?

(S)-2,3-oxidosqualene

beta-amyrin

Malus domestica

C7SCX0, C7SCX2

via dammarenyl cation

748772

-

-

r

(S)-2,3-oxidosqualene

delta-amyrin + beta-amyrin + alpha-amyrin + multiflorenol + psi-taraxasterol + taraxasterol + ?

Solanum lycopersicum

-

-

716616

isoform SITT1 produces 48% delta-amyrin, 13% beta-amyrin, 18% alpha-amyrin, and 3-7% each of multiflorenol, psi-taraxasterol, taraxasterol, and one unidentified triterpene alcohol isomer

-

?

(S)-2,3-oxidosqualene

lupeol

Malus domestica

C7SCX0, C7SCX2

via dammarenyl cation

748772

-

-

r

alpha-amyrin + beta-amyrin

(S)-2,3-oxidosqualene

Catharanthus roseus

-

-

730661

-

-

?

additional information

?

-

3 entries

(3S)-2,3-epoxy-2,3-dihydrosqualene

alpha-amyrin

Malus domestica

C7SCX0

the product alpha-amyrin is a precursor of ursolic acid

711990

-

-

?

(3S)-2,3-epoxy-2,3-dihydrosqualene

alpha-amyrin

Malus domestica

C7SCX0

the mixed amyrin synthase produces both alpha- and beta-amyrin in a ration of 5:1

711990

-

-

?

(3S)-2,3-epoxy-2,3-dihydrosqualene

alpha-amyrin

Pisum sativum

Q9LRH7

PSM produces both alpha- and beta-amyrin in about 3 : 2 ratio together with at least six other minor triterpenes

683422

-

-

?

(3S)-2,3-epoxy-2,3-dihydrosqualene

alpha-amyrin

Solanum lycopersicum

-

-

716616

isoform SITT1 produces 18% alpha-amyrin

-

?

additional information

?

-

Malus domestica

C7SCX0

MdOSC1 is a mixed amyrin synthase, with a 5:1 ratio of alpha-amyrin to beta-amyrin. The alpha-amyrin to beta-amyrin to lupeol production ratio for MdOSC1 is 85:13:2

748772

-

-

?

additional information

?

-

Malus domestica

C7SCX2

MdOSC1 is a mixed amyrin synthase, with a 5:1 ratio of alpha-amyrin to beta-amyrin. The alpha-amyrin to beta-amyrin to lupeol production ratio for MdOSC1 is 85:13:2

748772

-

-

?

additional information

?

-

Malus domestica

-

MdOSC1 is a mixed amyrin synthase, with a 5:1 ratio of alpha-amyrin to beta-amyrin. The alpha-amyrin to beta-amyrin to lupeol production ratio for MdOSC1 is 85:13:2

748772

-

-

?