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5.4.99.39: beta-amyrin synthase

This is an abbreviated version!
For detailed information about beta-amyrin synthase, go to the full flat file.

Word Map on EC 5.4.99.39

Reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene
=
beta-amyrin

Synonyms

AMS1, amyrin synthase, B-AS, bAS, BAS-like 2, BAS1, BAS2, beta-amyrin cyclase, beta-amyrin synthase, beta-AS, betaAS, BPY, CbbAS, CrAS, EsBAS, EtAS, GmAMS1, GsAS1, GsAS2, MdOSC1, MtAMY1, multifunctional OSC, ObAS1, OPSC 1, OSC, OSC1, OSC2, OXA1, Oxidosqualene cyclase, PBA, PlgOSC1, PNY, PSY, PtBS, SITTS1, SlTTS1, SvBS

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.99 Transferring other groups
                5.4.99.39 beta-amyrin synthase

Reference

Reference on EC 5.4.99.39 - beta-amyrin synthase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sawai, S.; Shindo, T.; Sato, S.; Kaneko, T.; Tabata, S.; Ayabe, S.; Aoki, T.
Functional and structural analysis of genes encoding oxidosqualene cyclases of Lotus japonicus
Plant Sci.
170
247-257
2006
Lotus japonicus
Manually annotated by BRENDA team
Hayashi, H.; Huang, P.; Kirakosyan, A.; Inoue, K.; Hiraoka, N.; Ikeshiro, Y.; Kushiro, T.; Shibuya, M.; Ebizuka, Y.
Cloning and characterization of a cDNA encoding beta-amyrin synthase involved in glycyrrhizin and soyasaponin biosyntheses in licorice
Biol. Pharm. Bull.
24
912-916
2001
Glycyrrhiza glabra
Manually annotated by BRENDA team
Zhang, H.; Shibuya, M.; Yokota, S.; Ebizuka, Y.
Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants
Biol. Pharm. Bull.
26
642-650
2003
Betula platyphylla (Q8W3Z1)
Manually annotated by BRENDA team
Kushiro, T.; Shibuya, M.; Ebizuka, Y.
beta-Amyrin synthase - cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants
Eur. J. Biochem.
256
238-244
1998
Panax ginseng (O82140), Panax ginseng
Manually annotated by BRENDA team
Morita, M.; Shibuya, M.; Kushiro, T.; Masuda, K.; Ebizuka, Y.
Molecular cloning and functional expression of triterpene synthases from pea (Pisum sativum) new alpha-amyrin-producing enzyme is a multifunctional triterpene synthase
Eur. J. Biochem.
267
3453-3460
2000
Pisum sativum
Manually annotated by BRENDA team
Basyuni, M.; Oku, H.; Tsujimoto, E.; Kinjo, K.; Baba, S.; Takara, K.
Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae
FEBS J.
274
5028-5042
2007
Bruguiera gymnorhiza (A8CDT2), Bruguiera gymnorhiza
Manually annotated by BRENDA team
Kirby, J.; Romanini, D.W.; Paradise, E.M.; Keasling, J.D.
Engineering triterpene production in Saccharomyces cerevisiae-beta-amyrin synthase from Artemisia annua
FEBS J.
275
1852-1859
2008
Artemisia annua
Manually annotated by BRENDA team
Kushiro, T.; Shibuya, M.; Ebizuka, Y.
Chimeric triterpene synthase. A possible model for multifunctional triterpene synthase
J. Am. Chem. Soc.
121
1208-1216
1999
Arabidopsis thaliana
-
Manually annotated by BRENDA team
Kushiro, T.; Shibuya, M.; Masuda, K.; Ebizuka, Y.
Mutational studies on triterpene synthases: engineering lupeol synthase into beta-amyrin synthase
J. Am. Chem. Soc.
122
6816-6824
2000
Panax ginseng
-
Manually annotated by BRENDA team
Abe, I.; Sakano, Y.; Tanaka, H.; Lou, W.; Noguchi, H.; Shibuya, M.; Ebizuka, Y.
Enzymatic cyclization of 22,23-dihydro-2,3-oxidosqualene into euph-7-en-3beta-ol and bacchar-12-en-3beta-ol by recombinant beta-amyrin synthase
J. Am. Chem. Soc.
126
3426-3427
2004
Pisum sativum
Manually annotated by BRENDA team
Abe, I.; Sakano, Y.; Sodeyama, M.; Tanaka, H.; Noguchi, H.; Shibuya, M.; Ebizuka, Y.
Mechanism and stereochemistry of enzymatic cyclization of 24,30-bisnor-2,3-oxidosqualene by recombinant beta-amyrin synthase
J. Am. Chem. Soc.
126
6880-6881
2004
Pisum sativum
Manually annotated by BRENDA team
Taton, M.; Ceruti, M.; Cattel, L.; Rahier, A.
Inhibition of higher plant 2,3-oxidosqualene cyclases by nitrogen-containing oxidosqualene analogs
Phytochemistry
43
75-81
1996
Pisum sativum
-
Manually annotated by BRENDA team
Kajikawa, M.; Yamato, K.T.; Fukuzawa, H.; Sakai, Y.; Uchida, H.; Ohyama, K.
Cloning and characterization of a cDNA encoding beta-amyrin synthase from petroleum plant Euphorbia tirucalli L.
Phytochemistry
66
1759-1766
2005
Euphorbia tirucalli (Q401R6), Euphorbia tirucalli
Manually annotated by BRENDA team
Iturbe-Ormaetxe, I.; Haralampidis, K.; Papadopoulou, K.; Osbourn, A.E.
Molecular cloning and characterization of triterpene synthases from Medicago truncatula and Lotus japonicus
Plant Mol. Biol.
51
731-743
2003
Medicago truncatula (Q84PE3), Medicago truncatula
Manually annotated by BRENDA team
Meesapyodsuk, D.; Balsevich, J.; Reed, D.W.; Covello, P.S.
Saponin biosynthesis in Saponaria vaccaria. cDNAs encoding beta-amyrin synthase and a triterpene carboxylic acid glucosyltransferase
Plant Physiol.
143
959-969
2007
Gypsophila vaccaria
Manually annotated by BRENDA team
Chung, E.; Cho, C.W.; Kim, K.Y.; Chung, J.; Kim, J.I.; Chung, Y.S.; Fukui, K.; Lee, J.H.
Molecular characterization of the GmAMS1 gene encoding beta -amyrin synthase in soybean plants
Russ. J. Plant Physiol.
54
518-523
2007
Glycine max (Q8H2B0)
-
Manually annotated by BRENDA team
Noma, H.; Tanaka, H.; Noguchi, H.; Shibuya, M.; Ebizuka, Y.; Abe, I.
Enzymatic formation of an unnatural novel tetracyclic sesterterpene by beta-amyrin synthase
Tetrahedron Lett.
45
8299-8301
2004
Pisum sativum
-
Manually annotated by BRENDA team
Confalonieri, M.; Cammareri, M.; Biazzi, E.; Pecchia, P.; Fevereiro, M.P.; Balestrazzi, A.; Tava, A.; Conicella, C.
Enhanced triterpene saponin biosynthesis and root nodulation in transgenic barrel medic (Medicago truncatula Gaertn.) expressing a novel beta-amyrin synthase (AsOXA1) gene
Plant Biotechnol. J.
7
172-182
2009
Aster sedifolius
Manually annotated by BRENDA team
Shibuya, M.; Katsube, Y.; Otsuka, M.; Zhang, H.; Tansakul, P.; Xiang, T.; Ebizuka, Y.
Identification of a product specific beta-amyrin synthase from Arabidopsis thaliana
Plant Physiol. Biochem.
47
26-30
2009
Arabidopsis thaliana (B6EXY6), Arabidopsis thaliana
Manually annotated by BRENDA team
Cammareri, M.; Consiglio, M.F.; Pecchia, P.; Corea, G.; Lanzotti, V.; Ibeas, J.I.; Tava, A.; Conicella, C.
Molecular characterization of ?-amyrin synthase from Aster sedifolius L. and triterpenoid saponin analysis
Plant Sci.
175
255-261
2008
Aster sedifolius (Q5D7Q8)
Manually annotated by BRENDA team
Brendolise, C.; Yauk, Y.K.; Eberhard, E.D.; Wang, M.; Chagne, D.; Andre, C.; Greenwood, D.R.; Beuning, L.L.
An unusual plant triterpene synthase with predominant alpha-amyrin-producing activity identified by characterizing oxidosqualene cyclases from Malus × domestica
FEBS J.
278
2485-2499
2011
Malus domestica (C7SCX1), Malus domestica
Manually annotated by BRENDA team
Sawai, S.; Uchiyama, H.; Mizuno, S.; Aoki, T.; Akashi, T.; Ayabe, S.; Takahashi, T.
Molecular characterization of an oxidosqualene cyclase that yields shionone, a unique tetracyclic triterpene ketone of Aster tataricus
FEBS Lett.
585
1031-1036
2011
Aster tataricus
Manually annotated by BRENDA team
Yendo, A.C.; de Costa, F.; Gosmann, G.; Fett-Neto, A.G.
Production of plant bioactive triterpenoid saponins: elicitation strategies and target genes to improve yields
Mol. Biotechnol.
46
94-104
2010
Aster sedifolius, Centella asiatica, Gentiana straminea, Gypsophila vaccaria, Medicago truncatula, Panax ginseng
Manually annotated by BRENDA team
Takagi, K.; Nishizawa, K.; Hirose, A.; Kita, A.; Ishimoto, M.
Manipulation of saponin biosynthesis by RNA interference-mediated silencing of beta-amyrin synthase gene expression in soybean
Plant Cell Rep.
30
1835-1846
2011
Glycine max
Manually annotated by BRENDA team
Wang, Z.; Guhling, O.; Yao, R.; Li, F.; Yeats, T.H.; Rose, J.K.; Jetter, R.
Two oxidosqualene cyclases responsible for biosynthesis of tomato fruit cuticular triterpenoids
Plant Physiol.
155
540-552
2011
Solanum lycopersicum, Solanum lycopersicum (E7DN63)
Manually annotated by BRENDA team
Shabani, L.; Ehsanpour, A.; Esmaeili, A.
Assessment of squalene synthase and beta-amyrin synthase gene expression in licorice roots treated with methyl jasmonate and salicylic acid using real-time qPCR
Russ. J. Plant Physiol.
57
480-484
2010
Glycyrrhiza glabra (Q9MB42)
-
Manually annotated by BRENDA team
Ito, R.; Hashimoto, I.; Masukawa, Y.; Hoshino, T.
Effect of cation-pi interactions and steric bulk on the catalytic action of oxidosqualene cyclase: a case study of Phe728 of beta-amyrin synthase from Euphorbia tirucalli L
Chemistry
19
17150-17158
2013
Euphorbia tirucalli (Q401R6)
Manually annotated by BRENDA team
Ito, R.; Masukawa, Y.; Hoshino, T.
Purification, kinetics, inhibitors and CD for recombinant beta-amyrin synthase from Euphorbia tirucalli L and functional analysis of the DCTA motif, which is highly conserved among oxidosqualene cyclases
FEBS J.
280
1267-1280
2013
Euphorbia tirucalli (Q401R6)
Manually annotated by BRENDA team
Yu, F.; Thamm, A.M.; Reed, D.; Villa-Ruano, N.; Quesada, A.L.; Gloria, E.L.; Covello, P.; De Luca, V.
Functional characterization of amyrin synthase involved in ursolic acid biosynthesis in Catharanthus roseus leaf epidermis
Phytochemistry
91
122-127
2013
Catharanthus roseus
Manually annotated by BRENDA team
Jin, M.L.; Lee, D.Y.; Um, Y.; Lee, J.H.; Park, C.G.; Jetter, R.; Kim, O.T.
Isolation and characterization of an oxidosqualene cyclase gene encoding a beta-amyrin synthase involved in Polygala tenuifolia Willd. saponin biosynthesis
Plant Cell Rep.
33
511-519
2014
Polygala tenuifolia
Manually annotated by BRENDA team
Misra, R.C.; Maiti, P.; Chanotiya, C.S.; Shanker, K.; Ghosh, S.
Methyl jasmonate-elicited transcriptional responses and pentacyclic triterpene biosynthesis in sweet basil
Plant Physiol.
164
1028-1044
2014
Ocimum basilicum
Manually annotated by BRENDA team
Jo, H.J.; Han, J.Y.; Hwang, H.S.; Choi, Y.E.
beta-Amyrin synthase (EsBAS) and beta-amyrin 28-oxidase (CYP716A244) in oleanane-type triterpene saponin biosynthesis in Eleutherococcus senticosus
Phytochemistry
135
53-63
2017
Eleutherococcus senticosus (A0A1P8W708), Eleutherococcus senticosus
Manually annotated by BRENDA team
Hoshino, T.; Nakagawa, K.; Aiba, Y.; Itoh, D.; Nakada, C.; Masukawa, Y.
Euphorbia tirucalli beta-amyrin synthase critical roles of steric sizes at Val483 and Met729 and the CH-Pi interaction between Val483 and Trp534 for catalytic action
ChemBioChem
18
2145-2155
2017
Euphorbia tirucalli (Q401R6)
Manually annotated by BRENDA team
Liu, J.; Xie, H.; Chen, H.; Qian, Z.
Cloning, prokaryotic expression, and functional identification of beta-amyrin synthase cDNA of Psammosilene tunicoides
Chin. Tradit. Herbal Drugs
45
1456-1460
2014
Psammosilene tunicoides (A5A5F1)
-
Manually annotated by BRENDA team
Sun, R.; Liu, S.; Tang, Z.Z.; Zheng, T.R.; Wang, T.; Chen, H.; Li, C.L.; Wu, Q.
beta-Amyrin synthase from Conyza blinii expressed in Saccharomyces cerevisiae
FEBS open bio
7
1575-1585
2017
Eschenbachia blinii (A0A2P0VE73)
Manually annotated by BRENDA team
Um, Y.; Jin, M.; Lee, D.; Kim, C.; Hong, C.; Lee, Y.; Kim, O.
Functional characterization of the beta-amyrin synthase gene involved in platycoside biosynthesis in Platycodon grandiflorum
Hortic. Environ. Biotechnol.
58
613-619
2017
Platycodon grandiflorus (A0A1Z2WUZ5)
-
Manually annotated by BRENDA team
Andre, C.; Legay, S.; Deleruelle, A.; Nieuwenhuizen, N.; Punter, M.; Brendolise, C.; Cooney, J.; Lateur, M.; Hausman, J.; Larondelle, Y.; Laing, W.
Multifunctional oxidosqualene cyclases and cytochrome P450 involved in the biosynthesis of apple fruit triterpenic acids
New Phytol.
211
1279-1294
2016
Malus domestica (C7SCX0), Malus domestica
Manually annotated by BRENDA team
Ito, R.; Masukawa, Y.; Nakada, C.; Amari, K.; Nakano, C.; Hoshino, T.
beta-Amyrin synthase from Euphorbia tirucalli. Steric bulk, not the Pi-electrons of Phe, at position 474 has a key role in affording the correct folding of the substrate to complete the normal polycyclization cascade
Org. Biomol. Chem.
12
3836-3846
2014
Euphorbia tirucalli (Q401R6)
Manually annotated by BRENDA team
Ito, R.; Nakada, C.; Hoshino, T.
beta-Amyrin synthase from Euphorbia tirucalli L. functional analyses of the highly conserved aromatic residues Phe413, Tyr259 and Trp257 disclose the importance of the appropriate steric bulk, and cation-Pi and CH-Pi interactions for the efficient catalytic
Org. Biomol. Chem.
15
177-188
2017
Euphorbia tirucalli (Q401R6)
Manually annotated by BRENDA team
Ma, Y.; Yang, R.; Zhou, S.; Yin, Y.; Zhang, X.; Liu, Y.
beta-Amyrin synthase, one of the most important key enzymes for triterpene skeleton formation in higher plants
Pak. J. Bot.
50
231-243
2018
Artemisia annua (B1P7H3), Avena longiglumis (Q6IWA0), Barbarea vulgaris (H9NAL5), Bupleurum chinense (B0ZSP3), Euphorbia tirucalli (Q401R6), Glycine max (Q8H2B0), Glycyrrhiza uralensis (D7P7W7), Gypsophila vaccaria (A3E7Y8), Medicago truncatula, Panax japonicus (A0A0H3YJP6), Panax quinquefolius (N0BQ25), Polygala tenuifolia (A1E4D1)
-
Manually annotated by BRENDA team
Liu, Y.; Zhao, Z.; Xue, Z.; Wang, L.; Cai, Y.; Wang, P.; Wei, T.; Gong, J.; Liu, Z.; Li, J.; Li, S.; Xiang, F.
An intronless beta-amyrin synthase gene is more efficient in oleanolic acid accumulation than its paralog in Gentiana straminea
Sci. Rep.
6
33364
2016
Gentiana straminea (A0A023U990), Gentiana straminea (C1K2M2), Gentiana straminea
Manually annotated by BRENDA team