5.4.99.25: tRNA pseudouridine55 synthase

This is an abbreviated version!
For detailed information about tRNA pseudouridine55 synthase, go to the full flat file.

Reaction

Synonyms

aCBF5, Cbf5, Mj-Pus10, MjPus10, More, pfuCbf5, pseudouridine 55 synthase, pseudouridine synthase, pseudouridine synthase Pus10, pseudouridine synthase TruB, pseuduridine-55 synthase, PSI synthase, PSI synthase TruB, PSI55 synthase, PSI55 synthaseuB, psi55 tRNA pseudouridine synthase, psi55S, Pus10, Pus4, RNA pseudouridine synthase TruB, TR, tRNA pseudouridine 55 synthase, tRNA pseudouridine synthase, tRNA PSI 55 synthase, tRNA:pseudouridine-55 synthase, tRNA:PSI55 synthase, tRNA:PSI55-synthase, TruB, YNL292w

ECTree

     5 Isomerases

         5.4 Intramolecular transferases

             5.4.99 Transferring other groups

                5.4.99.25 tRNA pseudouridine55 synthase

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Results	in table
6	Activating Compound
49363	AA Sequence
2	CAS Registry Number
13	Cloned(Commentary)
7	Crystallization (Commentary)
15	Disease/ Diagnostics
12	General Information
1	Inhibitors
10	kcat/KM [mM/s]
14	KM Value [mM]
2	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
31	Organism
5	pH Optimum
35	Protein Variants
9	Purification (Commentary)
7	Reaction
30	Reference
1	Source Tissue
23	Substrates and Products (Substrate)
3	Subunits
50	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
14	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 5.4.99.25 - tRNA pseudouridine55 synthase

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SYSTEMATIC NAME

IUBMB Comments

tRNA-uridine55 uracil mutase

Pseudouridine synthase TruB from Escherichia coli specifically modifies uridine55 in tRNA molecules [1]. The bifunctional archaeal enzyme also catalyses the pseudouridylation of uridine54 [6]. It is not known whether the enzyme from Escherichia coli can also act on position 54 in vitro, since this position is occupied in Escherichia coli tRNAs by thymine.