5.4.99.2: methylmalonyl-CoA mutase
This is an abbreviated version!
For detailed information about methylmalonyl-CoA mutase, go to the full flat file.
Word Map on EC 5.4.99.2
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5.4.99.2
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methylmalonic
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acidemia
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acidurias
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adenosylcobalamin
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propionate
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succinyl-coa
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inborn
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b12-dependent
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propionyl-coa
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adocbl
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homocysteine
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methylcobalamin
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apoenzyme
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shermanii
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adenosylcobalamin-dependent
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5\'-deoxyadenosylcobalamin
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propionibacterium
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hyperammonemia
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homolysis
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adenosylation
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homocystinuria
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mutases
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propionylcarnitine
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adenosyltransferase
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mmaa
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transcobalamins
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methylmalonyl-coenzyme
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propionyl
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adocbl-dependent
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odd-chain
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megaloblastic
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cobalt-carbon
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cyanocobalamin
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mmachc
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cobiialamin
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b12-binding
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hydroxycobalamin
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medicine
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mecbl
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cobalamin-binding
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cinnamonensis
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5\'-deoxyadenosyl
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isobutyryl-coa
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analysis
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extorquens
- 5.4.99.2
-
methylmalonic
- acidemia
- acidurias
- adenosylcobalamin
- propionate
- succinyl-coa
-
inborn
-
b12-dependent
- propionyl-coa
-
adocbl
- homocysteine
- methylcobalamin
-
apoenzyme
- shermanii
-
adenosylcobalamin-dependent
-
5\'-deoxyadenosylcobalamin
- propionibacterium
-
hyperammonemia
-
homolysis
-
adenosylation
- homocystinuria
- mutases
- propionylcarnitine
-
adenosyltransferase
- mmaa
-
transcobalamins
-
methylmalonyl-coenzyme
-
propionyl
-
adocbl-dependent
-
odd-chain
-
megaloblastic
-
cobalt-carbon
- cyanocobalamin
- mmachc
-
cobiialamin
-
b12-binding
- hydroxycobalamin
- medicine
-
mecbl
-
cobalamin-binding
- cinnamonensis
-
5\'-deoxyadenosyl
- isobutyryl-coa
- analysis
- extorquens
Reaction
Synonyms
(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase, (S)-Methylmalonyl-CoA mutase, cobalamin-dependent methylmalonyl-CoA mutase, hMCM, L-methylmalonyl-co-enzyme-A mutase, L-methylmalonyl-CoA mutase, MCB-beta, MCM, MCM-alpha, MCM-beta, mcmB, Methylmalonyl CoA mutase, Methylmalonyl coenzyme A carbonylmutase, Methylmalonyl coenzyme A mutase, methylmalonyl-CoA mutase, Methylmalonyl-CoA-carbonyl mutase, mitochondrial methylmalonyl-CoA mutase, mmcm-1, Msed_0638, Msed_2055, MuT, Mutase, methylmalonyl coenzyme A, Sbm, sleeping beauty mutase
ECTree
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Subunits
Subunits on EC 5.4.99.2 - methylmalonyl-CoA mutase
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dimer
heterodimer
heterotetramer
homodimer
monomer
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1 * 80000, SDS-PAGE, Sbm runs at 80000 Da monomer and 160000 Da dimer
additional information
?
x * 78000, SDS-PAGE and deduced from nucleotide sequence of gene mcmA, x * 64000, SDS-PAGE and deduced from nucleotide sequence of gene mcmB
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2 * 80000, non-denaturing PAGE, Sbm runs at 80000 Da monomer and 160000 Da dimer
dimer
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1 * 61000 + 1 * 66000, SDS-PAGE
dimer
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1 * 69465, beta-subunit, + 1 * 80147, alpha-subunit, calculation from nucleotide sequence
heterotetramer
O74009; O58013
alpha2beta2, the large and small subunits assemble in equimolar ratios and form heterotetrameric complexes in the presence of AdoCbl
heterotetramer
Pyrococcus horikoshii ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3
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alpha2beta2, the large and small subunits assemble in equimolar ratios and form heterotetrameric complexes in the presence of AdoCbl
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holomutase enzyme binds G-protein chaperone MeaB 15fold more tightly in presence of guanosine 5-(beta-gamma-imino)triphosphate than of GDP, the apomutase binds MeaB with similar affinity in presence of either nucleotide. a large structural rearrangement accompanies interaction between the proteins and buries between 4000 and 8600 A2 of surface area. The intrinsic low GTPase activity of MeaB is stimulated 100fold by binding to the mutase
additional information
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P-loop GTPase MeaB functions in GTP-dependent assembly of holomethyl-malonyl-CoA mutase and subsequent protection of radical intermediates during catalysis