5.4.99.2: methylmalonyl-CoA mutase
This is an abbreviated version!
For detailed information about methylmalonyl-CoA mutase, go to the full flat file.
Word Map on EC 5.4.99.2
-
5.4.99.2
-
methylmalonic
-
acidemia
-
acidurias
-
adenosylcobalamin
-
propionate
-
succinyl-coa
-
inborn
-
b12-dependent
-
propionyl-coa
-
adocbl
-
homocysteine
-
methylcobalamin
-
apoenzyme
-
shermanii
-
adenosylcobalamin-dependent
-
5\'-deoxyadenosylcobalamin
-
propionibacterium
-
hyperammonemia
-
homolysis
-
adenosylation
-
homocystinuria
-
mutases
-
propionylcarnitine
-
adenosyltransferase
-
mmaa
-
transcobalamins
-
methylmalonyl-coenzyme
-
propionyl
-
adocbl-dependent
-
odd-chain
-
megaloblastic
-
cobalt-carbon
-
cyanocobalamin
-
mmachc
-
cobiialamin
-
b12-binding
-
hydroxycobalamin
-
medicine
-
mecbl
-
cobalamin-binding
-
cinnamonensis
-
5\'-deoxyadenosyl
-
isobutyryl-coa
-
analysis
-
extorquens
- 5.4.99.2
-
methylmalonic
- acidemia
- acidurias
- adenosylcobalamin
- propionate
- succinyl-coa
-
inborn
-
b12-dependent
- propionyl-coa
-
adocbl
- homocysteine
- methylcobalamin
-
apoenzyme
- shermanii
-
adenosylcobalamin-dependent
-
5\'-deoxyadenosylcobalamin
- propionibacterium
-
hyperammonemia
-
homolysis
-
adenosylation
- homocystinuria
- mutases
- propionylcarnitine
-
adenosyltransferase
- mmaa
-
transcobalamins
-
methylmalonyl-coenzyme
-
propionyl
-
adocbl-dependent
-
odd-chain
-
megaloblastic
-
cobalt-carbon
- cyanocobalamin
- mmachc
-
cobiialamin
-
b12-binding
- hydroxycobalamin
- medicine
-
mecbl
-
cobalamin-binding
- cinnamonensis
-
5\'-deoxyadenosyl
- isobutyryl-coa
- analysis
- extorquens
Reaction
Synonyms
(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase, (S)-Methylmalonyl-CoA mutase, cobalamin-dependent methylmalonyl-CoA mutase, hMCM, L-methylmalonyl-co-enzyme-A mutase, L-methylmalonyl-CoA mutase, MCB-beta, MCM, MCM-alpha, MCM-beta, mcmB, Methylmalonyl CoA mutase, Methylmalonyl coenzyme A carbonylmutase, Methylmalonyl coenzyme A mutase, methylmalonyl-CoA mutase, Methylmalonyl-CoA-carbonyl mutase, mitochondrial methylmalonyl-CoA mutase, mmcm-1, Msed_0638, Msed_2055, MuT, Mutase, methylmalonyl coenzyme A, Sbm, sleeping beauty mutase
ECTree
Advanced search results
Reaction
Reaction on EC 5.4.99.2 - methylmalonyl-CoA mutase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
(R)-methylmalonyl-CoA = succinyl-CoA
mechanism
-
(R)-methylmalonyl-CoA = succinyl-CoA
evidence for radical intermediates
-
(R)-methylmalonyl-CoA = succinyl-CoA
intrinsic hydrogen isotope effect is 51 due to multidimensional tunneling. Corner-cutting tunneling decreases the distance over which the system tunnels without a comparable increase in either the effective potential barrier or the effective mass for tunneling
-
(R)-methylmalonyl-CoA = succinyl-CoA
ONIOM calculations based on protein structure. Homolytic Co-C5 bond cleavage in the 5-deoxyadenosylcobalamin cofactor is a stepwise process in which conformational changens in the 5-deoxyadenosine moiety proceed the actual homolysis step. The movement of the deoxyadenosine moity during homolysis positions the resulting 5-deoxyadenosyl radical for the subsequent hydrogen atom transfer from the substrate
-
(R)-methylmalonyl-CoA = succinyl-CoA
mechanism, overview, a gradual weakening of the electrostatic energy between the protein and the ribose leads to a progressive increase in the activation energy barrier for Co-C bond homolysis, key role for the conserved polar glutamate residue in controlling the initial generation of radical species