5.4.99.2: methylmalonyl-CoA mutase
This is an abbreviated version!
For detailed information about methylmalonyl-CoA mutase, go to the full flat file.
Word Map on EC 5.4.99.2
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5.4.99.2
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methylmalonic
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acidemia
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acidurias
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adenosylcobalamin
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propionate
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succinyl-coa
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inborn
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b12-dependent
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propionyl-coa
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adocbl
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homocysteine
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methylcobalamin
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apoenzyme
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shermanii
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adenosylcobalamin-dependent
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5\'-deoxyadenosylcobalamin
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propionibacterium
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hyperammonemia
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homolysis
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adenosylation
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homocystinuria
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mutases
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propionylcarnitine
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adenosyltransferase
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mmaa
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transcobalamins
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methylmalonyl-coenzyme
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propionyl
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adocbl-dependent
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odd-chain
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megaloblastic
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cobalt-carbon
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cyanocobalamin
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mmachc
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cobiialamin
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b12-binding
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hydroxycobalamin
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medicine
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mecbl
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cobalamin-binding
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cinnamonensis
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5\'-deoxyadenosyl
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isobutyryl-coa
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analysis
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extorquens
- 5.4.99.2
-
methylmalonic
- acidemia
- acidurias
- adenosylcobalamin
- propionate
- succinyl-coa
-
inborn
-
b12-dependent
- propionyl-coa
-
adocbl
- homocysteine
- methylcobalamin
-
apoenzyme
- shermanii
-
adenosylcobalamin-dependent
-
5\'-deoxyadenosylcobalamin
- propionibacterium
-
hyperammonemia
-
homolysis
-
adenosylation
- homocystinuria
- mutases
- propionylcarnitine
-
adenosyltransferase
- mmaa
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transcobalamins
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methylmalonyl-coenzyme
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propionyl
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adocbl-dependent
-
odd-chain
-
megaloblastic
-
cobalt-carbon
- cyanocobalamin
- mmachc
-
cobiialamin
-
b12-binding
- hydroxycobalamin
- medicine
-
mecbl
-
cobalamin-binding
- cinnamonensis
-
5\'-deoxyadenosyl
- isobutyryl-coa
- analysis
- extorquens
Reaction
Synonyms
(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase, (S)-Methylmalonyl-CoA mutase, cobalamin-dependent methylmalonyl-CoA mutase, hMCM, L-methylmalonyl-co-enzyme-A mutase, L-methylmalonyl-CoA mutase, MCB-beta, MCM, MCM-alpha, MCM-beta, mcmB, Methylmalonyl CoA mutase, Methylmalonyl coenzyme A carbonylmutase, Methylmalonyl coenzyme A mutase, methylmalonyl-CoA mutase, Methylmalonyl-CoA-carbonyl mutase, mitochondrial methylmalonyl-CoA mutase, mmcm-1, Msed_0638, Msed_2055, MuT, Mutase, methylmalonyl coenzyme A, Sbm, sleeping beauty mutase
ECTree
5.4.99.2 methylmalonyl-CoA mutaseAdvanced search results
results (
results (KM Value
KM Value on EC 5.4.99.2 - methylmalonyl-CoA mutase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.0279
(R)-2-methylmalonyl-CoA
in 100 mM potassium phosphate buffer (pH 7.5), at 37°C
0.102
(R)-2-methylmalonyl-CoA
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37°C, mutant H610N
0.124
(R)-2-methylmalonyl-CoA
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wild-type, pH 7.0, 37°C
0.133
(R)-2-methylmalonyl-CoA
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37°C, wild-type
0.152
(R)-2-methylmalonyl-CoA
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presence of P-loop GTPase MeaB and GDP, 37°C
0.364
(R)-2-methylmalonyl-CoA
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37°C, mutant H610A
0.00024
adenosylcobalamin
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37°C, wild-type
0.00045
adenosylcobalamin
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37°C, mutant H610A
0.00052
adenosylcobalamin
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37°C, mutant H610N
0.136
methylmalonyl-carba(dethia)-coenzyme A
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succinyl-carba(dethia)-CoA
0.357
methylmalonyl-CoA
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mutant Y89F, 37°C
0.3474
succinyl-CoA
in 100 mM potassium phosphate buffer (pH 7.5), at 37°C
additional information
additional information
Michaelis-Menten kinetics
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additional information
additional information
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KM not detectable, methylmalonyl-CoA, mutant Y89F/R207Q, 37°C
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additional information
additional information
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KM over 4, methylmalonyl-CoA, mutant R207Q, 37°C
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additional information
additional information
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Km value for mutant Y243A with substrate (R)-2-methylmalonyl-CoA is above 10 mM
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additional information
additional information
pre-steady-state and steady-state kinetics of wild-type and mutant enzymes
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additional information
additional information
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pre-steady-state and steady-state kinetics of wild-type and mutant enzymes
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