5.4.99.17: squalene-hopene cyclase
This is an abbreviated version!
For detailed information about squalene-hopene cyclase, go to the full flat file.
Word Map on EC 5.4.99.17
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5.4.99.17
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cyclization
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alicyclobacillus
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acidocaldarius
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hopanoids
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cyclases
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oxidosqualene
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pentacyclic
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triterpene
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2,3-oxidosqualene
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tetracyclic
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tetrahymanol
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carbocation
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polyolefinic
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5.4.99.7
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lanosterol
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aspartate-rich
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synthesis
- 5.4.99.17
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cyclization
- alicyclobacillus
- acidocaldarius
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hopanoids
- cyclases
- oxidosqualene
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pentacyclic
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triterpene
- 2,3-oxidosqualene
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tetracyclic
- tetrahymanol
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carbocation
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polyolefinic
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5.4.99.7
- lanosterol
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aspartate-rich
- synthesis
Reaction
Synonyms
AacSHC, cyclase, squalene-hopanoid, SHC, SHC1, SHC2, Spterp25, SQ-hopene cyclase, squalene hopene cyclase, squalene-hopene cyclase, ZmoSHC1, ZmSHC1
ECTree
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KM Value
KM Value on EC 5.4.99.17 - squalene-hopene cyclase
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0.001
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quintuple mutant, 50°C, pH 6.0
0.0023
(3S)-2,3-oxidosqualene
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sextuple mutant, 50°C, pH 6.0
0.0279
squalene
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mutant F605 changed to fluorophenylalanine plus mutation Y606A, pH 6.0, 50°C
0.0324
squalene
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mutant F605 changed to difluorophenylalanine plus mutation Y606A, pH 6.0, 50°C
0.0352
squalene
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mutant F365 changed to fluorophenylalanine, pH 6.0, 50°C
0.0416
squalene
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mutant F365 changed to difluorophenylalanine, pH 6.0, 50°C
0.0479
squalene
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mutant F6365 changed to trifluorophenylalanine, pH 6.0, 50°C
0.105
squalene
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mutant F605 changed to O-methyltyrosine, pH 6.0, 40°C
0.152
squalene
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mutant F605Y changed to O-methyltyrosine, pH 6.0, 50°C
0.185
squalene
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mutant F365Y changed to O-methyltyrosine, pH 6.0, 50°C
additional information
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Km for wild type and mutant enzymes
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additional information
additional information
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Km for wild type and mutant enzymes
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additional information
additional information
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Km for wild type and mutant enzymes
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additional information
additional information
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Km for wild type and mutant enzymes
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additional information
additional information
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Km for wild type and mutant enzymes
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additional information
additional information
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Km for wild type and mutant enzymes
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additional information
additional information
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squalene sextuple mutant: no activity
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