5.4.99.13: isobutyryl-CoA mutase
This is an abbreviated version!
For detailed information about isobutyryl-CoA mutase, go to the full flat file.
Word Map on EC 5.4.99.13
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5.4.99.13
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methylmalonyl-coa
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b12-dependent
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mutases
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acyl-coas
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n-butyryl-coa
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cinnamonensis
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icmfs
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polyketide
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succinyl-coa
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monensin
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isomerases
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meaa
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5'-deoxyadenosylcobalamin-dependent
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2-hydroxyisobutyrate
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extorquens
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isobutyrate
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cobiialamin
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2r-methylmalonyl-coa
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synthesis
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b12-binding
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mutase-catalyzed
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5'-deoxyadenosine
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5\'-deoxyadenosyl
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coa-dependent
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isobutanol
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methylmalonyl
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methylobacterium
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crotonyl-coa
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pivalic
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biofuel production
- 5.4.99.13
- methylmalonyl-coa
-
b12-dependent
- mutases
- acyl-coas
- n-butyryl-coa
- cinnamonensis
-
icmfs
- polyketide
- succinyl-coa
- monensin
- isomerases
- meaa
-
5'-deoxyadenosylcobalamin-dependent
- 2-hydroxyisobutyrate
- extorquens
- isobutyrate
-
cobiialamin
-
2r-methylmalonyl-coa
- synthesis
-
b12-binding
-
mutase-catalyzed
- 5'-deoxyadenosine
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5\'-deoxyadenosyl
-
coa-dependent
- isobutanol
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methylmalonyl
- methylobacterium
- crotonyl-coa
-
pivalic
- biofuel production
Reaction
Synonyms
adenosylcobalamin-dependent isobutyryl-CoA mutase, AdoCbl-dependent PCM, butyryl-CoA:isobutyryl-CoA mutase, CmIcmF, ICM, IcmF, isobutyryl coenzyme A mutase, isobutyryl-CoA mutase fused, isovaleryl-CoA/pivalyl-CoA mutase, PCM, pivalyl-CoA mutase
ECTree
5.4.99.13 isobutyryl-CoA mutaseAdvanced search results
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results (KM Value
KM Value on EC 5.4.99.13 - isobutyryl-CoA mutase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
additional information
additional information
the pivalyl-CoA mutase activity of engineered PCM shows a sigmoidal dependence on the concentration of isolvaleryl-CoA
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0.36
2-methylpropanoyl-CoA
recombinant mutant F598I, pH 7.5, 37°C
0.45
2-methylpropanoyl-CoA
recombinant mutant F598A, pH 7.5, 37°C
0.67
2-methylpropanoyl-CoA
recombinant mutant F598V, pH 7.5, 37°C
0.79
2-methylpropanoyl-CoA
recombinant mutant Q742A, pH 7.5, 37°C
0.89
2-methylpropanoyl-CoA
recombinant mutant F598L, pH 7.5, 37°C
1.1
2-methylpropanoyl-CoA
recombinant wild-type enzyme, pH 7.5, 37°C
2.4
2-methylpropanoyl-CoA
recombinant mutant Q742N, pH 7.5, 37°C
0.0453
isobutyryl-CoA
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recombinant enzyme, in the presence of GDP, in 50 mM sodium phosphate buffer, pH 7.5, 250 mM NaCl at 37°C
0.0508
isobutyryl-CoA
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recombinant enzyme, in the presence of GTP, in 50 mM sodium phosphate buffer, pH 7.5, 250 mM NaCl at 37°C
0.2
isovaleryl-CoA
recombinant engineered PCM-F mutant, pH 7.5, 37°C
0.37
isovaleryl-CoA
recombinant engineered PCM mutant, pH 7.5, 37°C
1.4
isovaleryl-CoA
recombinant wild-type enzyme, pH 7.5, 37°C
