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5.4.99.13: isobutyryl-CoA mutase

This is an abbreviated version!
For detailed information about isobutyryl-CoA mutase, go to the full flat file.

Word Map on EC 5.4.99.13

Reaction

2-methylpropanoyl-CoA
=
butanoyl-CoA

Synonyms

adenosylcobalamin-dependent isobutyryl-CoA mutase, AdoCbl-dependent PCM, butyryl-CoA:isobutyryl-CoA mutase, CmIcmF, ICM, IcmF, isobutyryl coenzyme A mutase, isobutyryl-CoA mutase fused, isovaleryl-CoA/pivalyl-CoA mutase, PCM, pivalyl-CoA mutase

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.99 Transferring other groups
                5.4.99.13 isobutyryl-CoA mutase

Inhibitors

Inhibitors on EC 5.4.99.13 - isobutyryl-CoA mutase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
GDP
-
the presence of GDP decreases kcat about 1.6-1.7fold while increasing the Km about 2fold. Consequently, the catalytic efficiency kcat/Km value of IcmF decreases 3fold in the presence of GDP
GTP
-
the presence of GTP decreases kcat about 1.6-1.7fold while increasing the Km about 2fold. Consequently, the catalytic efficiency kcat/Km value of IcmF decreases 4.5fold in the presence of GTP
additional information
inactivation rates of OH2Cbl formation for wild-type and mutant enzymes, overview
-