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5.4.4.7: hydroperoxy icosatetraenoate isomerase

This is an abbreviated version!
For detailed information about hydroperoxy icosatetraenoate isomerase, go to the full flat file.

Word Map on EC 5.4.4.7

Reaction

a hydroperoxyicosatetraenoate
=
a hydroxyepoxyicosatrienoate

Synonyms

ALOXE3, eLOX-3, eLOX3, epidermal lipoxygenase-3, epidermal LOX type 3, hepoxilin synthase

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.4 Transferring hydroxy groups
                5.4.4.7 hydroperoxy icosatetraenoate isomerase

General Information

General Information on EC 5.4.4.7 - hydroperoxy icosatetraenoate isomerase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
intra-amniotic delivery of epidermal lipoxygenase-3 (eLOX-3) to mice at gestational day 14.5, both via an adenoviral vector and as recombinant protein, results in fetal growth restriction and intrauterine death. Periodic acid-Schiff staining and RT-PCR analysis of placentae from fetuses exposed to eLOX-3 indicate a lack of glycogen trophoblasts in the junctional zone. Placenta-specific gene expression is altered. Thus, the observed prenatal toxicity of eLOX-3 can be due to a strong effect on placental development. Placentae from eLOX-3-exposed fetuses have an altered structure. Short life-span of eLOX-3 null mice
metabolism
-
eLOX3, is not a functional lipoxygenase enzyme, but has catalytic activity as a hydroperoxide isomerase
physiological function