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5.4.4.7: hydroperoxy icosatetraenoate isomerase

This is an abbreviated version!
For detailed information about hydroperoxy icosatetraenoate isomerase, go to the full flat file.

Word Map on EC 5.4.4.7

Reaction

a hydroperoxyicosatetraenoate
=
a hydroxyepoxyicosatrienoate

Synonyms

ALOXE3, eLOX-3, eLOX3, epidermal lipoxygenase-3, epidermal LOX type 3, hepoxilin synthase

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.4 Transferring hydroxy groups
                5.4.4.7 hydroperoxy icosatetraenoate isomerase

Engineering

Engineering on EC 5.4.4.7 - hydroperoxy icosatetraenoate isomerase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
R396S
-
no detectable activity with (12R)-HPETE
V500F
-
no detectable activity with (12R)-HPETE
additional information
intra-amniotic delivery of eLOX-3 to mice at gestational day 14.5, both via an adenoviral vector and as recombinant protein, expression of the placenta-specific genes Tpbpa, Pcdh12, Muc1, Gcm1, SynA, and PL-1, encoding trophoblast-specific protein alpha, protocadherin 12, mucin 1, glial cell missing homologue 1, syncytin A, and placental lactogen 1, respectively, is analyzed in SYBR green-based real-time RT-PCR assays. Analysis of toxicity of eLOX-3 and dose-dependence of fetal survival, overview. Placentae from eLOX-3-exposed fetuses have an altered structure