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5.4.3.8: glutamate-1-semialdehyde 2,1-aminomutase

This is an abbreviated version!
For detailed information about glutamate-1-semialdehyde 2,1-aminomutase, go to the full flat file.

Word Map on EC 5.4.3.8

Reaction

L-glutamate 1-semialdehyde
=
5-aminolevulinate

Synonyms

Aminotransferase, glutamate semialdehyde, AtGSA1, EC 2.7.2.13, Glutamate 1-semialdehyde aminotransferase, glutamate-1-semialdehyde amino-transferase, glutamate-1-semialdehyde aminomutase, Glutamate-1-semialdehyde aminotransferase, glutamate-1-semialdehyde-2,1-aminomutase, glutamate-1-semialdehyde-aminomutase, GSA, GSA aminotransferase, GSA-AT, GSA1, GSAM, GSAT, HemL, PA4088, protein PA4088

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.3 Transferring amino groups
                5.4.3.8 glutamate-1-semialdehyde 2,1-aminomutase

Reference

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Reference on EC 5.4.3.8 - glutamate-1-semialdehyde 2,1-aminomutase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kannangara, C.G.; Gough, S.P.
Biosynthesis of DELTA-aminolevulinate in greening barley leaves: glutamate 1-semialdehyde aminotransferase
Carlsberg Res. Commun.
43
185-194
1978
Hordeum vulgare
-
Manually annotated by BRENDA team
Kannangara, C.G.; Gough, S.P.
Biosynthesis of DELTA-aminolevulinate in greening barley leaves II: induction of enzyme synthesis by light
Carlsberg Res. Commun.
44
11-20
1979
Hordeum vulgare
-
Manually annotated by BRENDA team
Henning, M.; Grimm, B.; Jenny, M.; Muller, R.; Jansonius, J.N.
Crystallization and preliminary X-ray analysis of wild-type and K272A mutant glutamate 1-semialdehyde aminotransferase from Synechococcus
J. Mol. Biol.
242
591-594
1994
Synechococcus sp.
Manually annotated by BRENDA team
Wang, W.Y.; Huang, D.D.; Stachon, D.; Gough, S.P.; Kannangara, C.G.
Purification, characterization, and fractionation of the delta-aminolevulinic acid synthesizing enzymes from light-grown Chlamydomonas reinhardtii cells
Plant Physiol.
74
569-575
1984
Chlamydomonas reinhardtii
Manually annotated by BRENDA team
Kannangara, C.G.; Schouboe, A.
Biosynthesis of DELTA-aminolevulinate in greeng barley leaves. VII. Glutamate 1-semialdehyde accumulation in gabaculine treated leaves
Carlsberg Res. Commun.
50
179-191
1985
Hordeum vulgare
-
Manually annotated by BRENDA team
Mau, Y.H.L.; Wang, W.Y.
Biosynthesis of delta-aminolevulinic acid in Chlamydomonas reinhardtii. Study of the transamination mechanism using specifically labelled glutamate
Plant Physiol.
86
793-797
1988
Chlamydomonas reinhardtii
Manually annotated by BRENDA team
Hoober, J.K.; Kahn, A.; Ash, D.E.; Gough, S.P.; Kannangara, C.G.
Biosynthesis of DELTA-aminolevulinate in greening barley leaves. IX. Structure of the substrate, mode of gabaculine inhibition, and the catalytic mechanism of glutamate 1-semialdehyde aminotransferase
Carlsberg Res. Commun.
53
11-25
1988
Hordeum vulgare
Manually annotated by BRENDA team
Rieble, S.; Beale, S.I.
Separation and partial characterization of enzymes catalyzing delta-aminolevulinic acid formation in Synechocystis sp. PCC 6803
Arch. Biochem. Biophys.
289
289-297
1991
Synechococcus sp.
Manually annotated by BRENDA team
Berry-Lowe, S.L.; Grimm, B.; Smith, M.A.; Kannangara, C.G.
Purification and characterization of glutamate 1-semialdehyde aminotransferase from barley expressed in Escherichia coli
Plant Physiol.
99
1597-1603
1992
Hordeum vulgare
Manually annotated by BRENDA team
Grimm, B.; Bull, A.; Welinder, K.G.; Gough, S.P.; Kannangara, C.G.
Purification and partial amino acid sequence of the glutamate 1-semialdehyde aminotransferase of barley and Synechococcus
Carlsberg Res. Commun.
54
67-79
1989
Hordeum vulgare, Synechococcus sp.
Manually annotated by BRENDA team
Bull, A.D.; Breu, V.; Kannangara, C.G.; Rogers, L.J.; Smith, A.J.
Cyanobacterial glutamate 1-semialdehyde aminotransferase: requirement for pyridoxal phosphate
Arch. Microbiol.
154
56-59
1990
Synechococcus sp.
-
Manually annotated by BRENDA team
Smith, M.A.; Grimm, B.
Gabaculine resistance of Synechococcus glutamate 1-semialdehyde aminotransferase
Biochemistry
31
4122-4127
1992
Synechococcus sp.
Manually annotated by BRENDA team
Nair, S.P.; Kannangara, C.G.; Harwood, J.L.; John, R.A.
Inhibition studies on 5-amino-4-oxopentanoate biosynthesis in Pisum sativum L. (pea)
Biochem. Soc. Trans.
18
656-657
1990
Pisum sativum
Manually annotated by BRENDA team
Ilag, L.L.; Jahn, D.
Activity and spectroscopic properties of the Escherichia coli glutamate 1-semialdehyde aminotransferase and the putative active site mutant K265R
Biochemistry
31
7143-7151
1992
Escherichia coli
Manually annotated by BRENDA team
Smith, M.A.; Kannangara, C.G.; Grimm, B.
Glutamate 1-semialdehyde aminotransferase: anomalous enantiomeric reaction and enzyme mechanism
Biochemistry
31
11249-11254
1992
Synechococcus sp.
Manually annotated by BRENDA team
Mayer, S.M.; Rieble, S.; Beale, S.I.
Metal requirement of the enzymes catalyzing conversion of glutamate to delta-aminolevulinic acid in extracts of Chlorella vulgaris and Synechocystis sp. PCC 6803
Arch. Biochem. Biophys.
312
203-209
1994
Chlorella vulgaris, Synechococcus sp.
Manually annotated by BRENDA team
Brody, S.; Andersen, J.S.; Kannangara, C.G.; Meldgaard, M.; Roepstorff, P.; von Wettstein, D.
Characterization of the different spectral forms of glutamate 1-semialdehyde aminotransferase by mass spectrometry
Biochemistry
34
15918-15924
1995
Synechococcus sp.
Manually annotated by BRENDA team
Jahn, D.; Chen, M.W.; Söll, D.
Purification and functional characterization of glutamate-1-semialdehyde aminotransferase from Chlamydomonas reinhardtii
J. Biol. Chem.
266
161-167
1991
Chlamydomonas reinhardtii
Manually annotated by BRENDA team
Grimm, B.
Primary structure of a key enzyme in plant tetrapyrrole synthesis glutamate 1-semialdehyde aminotransferase
Proc. Natl. Acad. Sci. USA
87
4169-4173
1990
Hordeum vulgare
Manually annotated by BRENDA team
Nair, S.P.; Harwood, J.L.; John, R.A.
Direct identification and quantification of the cofactor in glutamate semialdehyde aminotransferase from pea leaves
FEBS Lett.
283
4-6
1991
Pisum sativum
Manually annotated by BRENDA team
Pugh, C.E.; Harwood, J.L.; John, R.A.
Mechanism of glutamate semialdehyde aminotransferase roles of diamino- and dioxo-intermediates in the synthesis of aminolevulinate
J. Biol. Chem.
267
1584-1588
1992
Pisum sativum
Manually annotated by BRENDA team
Palmieri, G.; di Palo, M.; Scaloni, A.; Orru, S.; Marino, G.; Sannia, G.
Glutamate-1-semialdehyde aminotransferase from Sulfolobus solfataricus
Biochem. J.
320
541-545
1996
Saccharolobus solfataricus (Q980U5), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q980U5)
Manually annotated by BRENDA team
Smith, M.A.; Kannangara, C.G.; Grimm, B.; von Wettstein, D.
Characterization of glutamate-1-semialdehyde aminotransferase of Synechococcus. Steady-state kinetic analysis
Eur. J. Biochem.
202
749-757
1991
Synechococcus sp.
Manually annotated by BRENDA team
Tyacke, R.J.; Harwood, J.L.; John, R.A.
Properties of the pyridoxaldimine form of glutamate semialdehyde aminotransferase (glutamate-1-semialdehyde 2,1-aminomutase) and analysis of its role as an intermediate in the formation of aminolaevulinate
Biochem. J.
293
697-791
1993
Pisum sativum
Manually annotated by BRENDA team
Murakami, K.; Hashimoto, Y.; Murooka, Y.
Cloning and characterization of the gene encoding glutamate 1-semialdehyde 2,1-aminomutase, which is involved in delta-aminolevulinic acid synthesis in Propionibacterium freudenreichii
Appl. Environ. Microbiol.
59
347-350
1993
Propionibacterium freudenreichii
Manually annotated by BRENDA team
Murakami, K.; Korbsrisate, S.; Asahara, N.; Hashimoto, Y.; Murooka, Y.
Cloning and characterization of the glutamate 1-semialdehyde aminomutase gene from Xanthomonas campestris pv. phaseoli
Appl. Microbiol. Biotechnol.
38
502-506
1993
Xanthomonas campestris
Manually annotated by BRENDA team
Grimm, H.M.; Contestabile, R.; John, R.A.; Jansonius, J.N.
Crystal structure of glutamate-1-semialdehyde aminomutase: an alpha2-dimeric vitamin B6-dependent enzyme with asymmetry in structure and active reactivity
Proc. Natl. Acad. Sci. USA
84
4866-4871
1997
Synechococcus sp.
-
Manually annotated by BRENDA team
Smith, M.A.; King, P.J.; Grimm, B.
Transient-state kinetic analysis of Synechococcus glutamate 1-semialdehyde aminotransferase
Biochemistry
37
319-329
1998
Synechococcus sp.
Manually annotated by BRENDA team
Tsang, E.W.; Hu, Z.; Chang, Q.; McGregor, D.I.; Keller, W.A.
Expression of a Brassic napus glutamate 1-semialdehyde aminotransferase in Escherichia coli and characterization of the recombinant protein
Protein Expr. Purif.
29
193-201
2003
Brassica napus
Manually annotated by BRENDA team
Lüer, C.; Schauer, S.; Mobius, K.; Schulze, J.; Schubert, W.D.; Heinz, D.W.; Jahn, D.; Moser, J.
Complex formation between glutamyl-tRNA reductase and glutamate-1-semialdehyde 2,1-aminomutase in Escherichia coli during the initial reactions of porphyrin biosynthesis
J. Biol. Chem.
280
18568-18572
2005
Escherichia coli
Manually annotated by BRENDA team
Lv, X.; Fan, J.; Ge, H.; Gao, Y.; Zhang, X.; Teng, M.; Niu, L.
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the glutamate-1-semialdehyde aminotransferase from Bacillus subtilis
Acta Crystallogr. Sect. F
62
483-485
2006
Bacillus subtilis
Manually annotated by BRENDA team
Stetefeld, J.; Jenny, M.; Burkhard, P.
Intersubunit signaling in glutamate-1-semialdehyde-aminomutase
Proc. Natl. Acad. Sci. USA
103
13688-13693
2006
Synechococcus sp. (P24630)
Manually annotated by BRENDA team
Orriss, G.L.; Patel, T.R.; Sorensen, J.; Stetefeld, J.
Absence of a catalytic water confers resistance to the neurotoxin gabaculine
FASEB J.
24
404-414
2010
Synechococcus sp. (P24630)
Manually annotated by BRENDA team
Ge, H.; Lv, X.; Fan, J.; Gao, Y.; Teng, M.; Niu, L.
Crystal structure of glutamate-1-semialdehyde aminotransferase from Bacillus subtilis with bound pyridoxamine-5-phosphate
Biochem. Biophys. Res. Commun.
402
356-360
2010
Bacillus subtilis (P30949), Bacillus subtilis
Manually annotated by BRENDA team
Kang, Z.; Wang, Y.; Gu, P.; Wang, Q.; Qi, Q.
Engineering Escherichia coli for efficient production of 5-aminolevulinic acid from glucose
Metab. Eng.
13
492-498
2011
Escherichia coli, Escherichia coli MG1655
Manually annotated by BRENDA team
Matters, G.L.; Beale, S.L.
Biosynthesis of delta-aminolevulinic acid from glutamate by Sulfolobus solfataricus
Arch. Microbiol.
161
272-276
1994
Saccharolobus solfataricus, Saccharolobus solfataricus 98-3
-
Manually annotated by BRENDA team
Campanini, B.; Bettati, S.; di Salvo, M.L.; Mozzarelli, A.; Contestabile, R.
Asymmetry of the active site loop conformation between subunits of glutamate-1-semialdehyde aminomutase in solution
BioMed Res. Int.
2013
353270
2013
Synechococcus sp.
Manually annotated by BRENDA team
Song, Y.; Pu, H.; Jiang, T.; Zhang, L.; Ouyang, M.
Crystal structure of glutamate-1-semialdehyde-2,1-aminomutase from Arabidopsis thaliana
Acta Crystallogr. Sect. F
72
448-456
2016
Arabidopsis thaliana (P42799), Arabidopsis thaliana
Manually annotated by BRENDA team
Li, S.; Lou, X.; Xu, Y.; Teng, X.; Che, S.; Liu, R.; Bartlam, M.
Crystal structure of a glutamate-1-semialdehyde-aminomutase from Pseudomonas aeruginosa PAO1
Biochem. Biophys. Res. Commun.
500
804-809
2018
Pseudomonas aeruginosa (Q9HWU0), Pseudomonas aeruginosa ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1 (Q9HWU0)
Manually annotated by BRENDA team
Ramzi, A.B.; Hyeon, J.E.; Kim, S.W.; Park, C.; Han, S.O.
5-Aminolevulinic acid production in engineered Corynebacterium glutamicum via C5 biosynthesis pathway
Enzyme Microb. Technol.
81
1-7
2015
Corynebacterium glutamicum (Q8NT73), Corynebacterium glutamicum ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025 (Q8NT73)
Manually annotated by BRENDA team