5.4.3.6: tyrosine 2,3-aminomutase

This is an abbreviated version!
For detailed information about tyrosine 2,3-aminomutase, go to the full flat file.

Reaction

Synonyms

3,5-dihydro-5-methylidene-4H-imidazol-4-one-dependent aminomutase, 3,5-dihydro-5-methylidine-4H-imidazol-4-one-dependent tyrosine aminomutase, Aminomutase, tyrosine 2,3-, CmdF, MfTAM, MIO-dependent aminomutase, MIO-dependent tyrosine aminomutase, More, MxTAM, OsTAM, SgcC4, TAM, Tam1, Tyrosine alpha,beta-amino mutase, Tyrosine alpha,beta-mutase, tyrosine aminomutase

ECTree

     5 Isomerases

         5.4 Intramolecular transferases

             5.4.3 Transferring amino groups

                5.4.3.6 tyrosine 2,3-aminomutase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
152	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
4	Cofactor
2	Crystallization (Commentary)
2	Expression
9	General Information
1	General Stability
6	IC50 Value
18	Inhibitors
10	kcat/KM [mM/s]
16	KM Value [mM]
2	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
16	Organism
4	Pathway
8	PDB ID
7	pH Optimum
2	pH Range
43	Protein Variants
8	Purification (Commentary)
5	Reaction
5	Reaction Type
16	Reference
5	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
35	Substrates and Products (Substrate)
2	Subunits
35	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
18	Turnover Number [1/s]

General Information

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

General Information on EC 5.4.3.6 - tyrosine 2,3-aminomutase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to General Information Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

Oryza sativa

-

MIO-dependent aminomutases belong to a class I lyase-like family, in which the MIO group is formed by condensation and cyclization of backbone residues of an (A, T, or S)-Ser-Gly triad in the active site. The active sites of rice tyrosine aminomutase and Taxus canadensis phenylalanine aminomutase share a high degree of sequence identity, which may in part explain why OsTAM also converts phenylalanine to beta-phenylalanine

747148

malfunction

Oryza sativa Japonica Group

-

rice cultivars that do not produce beta-tyrosine have a chromosome 12 deletion that encompasses TAM1

748914

metabolism

Chondromyces crocatus

Q0VZ68

(R)-beta-tyrosine is incorporated into the chondramides produced by Chondromyces crocatus

703203

physiological function

2 entries

additional information

4 entries

physiological function

Oryza sativa

-

MIO (3,5-dihydro-5-methylidene-4H-imidazol-4-one)-dependent aminomutases (AMs) are involved in the the biosynthetic pathways of biologically active, medicinal compounds in plants and microorganisms

747148

physiological function

Oryza sativa Japonica Group

-

tyrosine aminomutase TAM1 is required for beta-tyrosine biosynthesis in Oryza sativa, the tyrosine aminomutase converts the common protein amino acid tyrosine (alpha-tyrosine) into beta-tyrosine. beta-Tyrosine is most prevalent in temperate japonica cultivars. beta-Tyrosine is exuded into hydroponic medium at higher concentrations and may contribute to the allelopathic potential of rice. Pseudomonas syringae growth is inhibited by beta-tyrosine, and seedlings of dicot species are much more sensitive to exogenous beta-tyrosine than rice and other tested monocots

748914

additional information

Chondromyces crocatus

-

cryptic stereochemistry of the enzyme mechanism, structure-function relationship, detailed overview

727685

additional information

Oryza sativa Japonica Group

-

hemipteran and lepidopteran herbivores show no negative effects at physiologically relevant beta-tyrosine concentrations

748914

additional information

Oryza sativa

-

homology modeling of wild-type enzyme OsTAM and OsTAM mutant enzymes using the phenylalanine aminomutase structure from Taxus canadensis with PDB ID 3NZ4 as template. The active site of enzyme TAM has a flexible inner loop region

747148

additional information

Oryza sativa

-

residues Y125 and N446 not only play a central role in substrate selectivity but, in part, also set the intrinsic reactivity of OsTAM

747104