5.4.2.8: phosphomannomutase
This is an abbreviated version!
For detailed information about phosphomannomutase, go to the full flat file.
Word Map on EC 5.4.2.8
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5.4.2.8
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carbohydrate-deficient
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transferrin
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gdp-mannose
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multisystemic
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cdg-ia
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team
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mannose-1-phosphate
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pectoralis
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phosphoglucomutase
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doctors
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obstetric
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hypoglycosylation
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nipple
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lipid-linked
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psoas
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premammillary
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strabismus
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paromomycin
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meniscectomy
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medicine
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food industry
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biotechnology
- 5.4.2.8
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carbohydrate-deficient
- transferrin
- gdp-mannose
-
multisystemic
-
cdg-ia
-
team
- mannose-1-phosphate
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pectoralis
- phosphoglucomutase
-
doctors
-
obstetric
-
hypoglycosylation
-
nipple
-
lipid-linked
-
psoas
-
premammillary
-
strabismus
- paromomycin
-
meniscectomy
- medicine
- food industry
- biotechnology
Reaction
Synonyms
alpha-D-phosphohexomutase, alpha-phosphomannomutase1, EC 2.7.5.7, IMP-sensitive glucose-1,6-bisphosphatase, ManB, ORF17, PGM/PMM, PGM2, PgmG, phosphoglucomutase/phosphomannomutase, Phosphohexomutase, phosphomannomutase, phosphomannomutase 1, phosphomannomutase 2, phosphomannomutase/phosphoglucomutase, phosphomannomutase2, Phosphomannose mutase, Phosphomutase, mannose, PMM, PMM-1, PMM-2, PMM-A1, PMM-A2, PMM-B1, PMM-B2, PMM-D1, PMM-D2, PMM/PGM, PMM1, PMM2, PMMH-22, SP-2, SSO0207
ECTree
5.4.2.8 phosphomannomutaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 5.4.2.8 - phosphomannomutase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
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r
D-mannose 6-phosphate
alpha-D-mannose 1-phosphate
it is unclear whether either glucose or mannose phosphate represents the cellular substrate for SsoPHM. The Km values for rSsoPHM toward glucose 6-phosphate and mannose 6-phosphate are in the low millimolar range, significantly higher than that expected for a physiological substrate. Since the protein encoded by sso0207 is the only identifiable phosphohexomutase in the Sulfolbus solfataricus P2 genome, SsoPHM provides the only recognizable avenue for interconverting glucose 6-phosphate and glucose 1-phosphate during glycogen synthesis and breakdown
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r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
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-
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r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
PMM/PGM catalyzes the second step in alginate biosynthesis
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r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
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second step of the alginate biosynthetic pathway
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r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
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20fold higher activity than with alpha-D-glucose 1-phosphate
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r
alpha-D-mannose 1-phosphate
D-mannose 6-phosphate
it is unclear whether either glucose or mannose phosphate represents the cellular substrate for SsoPHM. The Km values for rSsoPHM toward glucose 6-phosphate and mannose 6-phosphate are in the low millimolar range, significantly higher than that expected for a physiological substrate. Since the protein encoded by sso0207 is the only identifiable phosphohexomutase in the Sulfolbus solfataricus P2 genome, SsoPHM provides the only recognizable avenue for interconverting glucose 6-phosphate and glucose 1-phosphate during glycogen synthesis and breakdown
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r
alpha-D-mannose 1-phosphate
D-mannose 6-phosphate
it is unclear whether either glucose or mannose phosphate represents the cellular substrate for SsoPHM. The Km values for rSsoPHM toward glucose 6-phosphate and mannose 6-phosphate are in the low millimolar range, significantly higher than that expected for a physiological substrate. Since the protein encoded by sso0207 is the only identifiable phosphohexomutase in the Sulfolbus solfataricus P2 genome, SsoPHM provides the only recognizable avenue for interconverting glucose 6-phosphate and glucose 1-phosphate during glycogen synthesis and breakdown
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r
alpha-D-mannose 1-phosphate
D-mannose 6-phosphate
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-
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?
D-mannose 6-phosphate
D-mannose 1-phosphate
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conversion to mannose 1-phosphate, which is a substrate for the synthesis of GDPmannose. This nucleotide sugar is then used in the synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol anchored proteins
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?
D-mannose 6-phosphate
D-mannose 1-phosphate
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first enzyme of the N-glycosylation pathway
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?
D-mannose 6-phosphate
D-mannose 1-phosphate
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the enzyme produces mannose 1-phosphate for the synthesis of mannose-1,6-diphosphate as well as of GDPmannose
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?
D-mannose 6-phosphate
D-mannose 1-phosphate
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the enzyme is required for synthesis of lipopolysaccharide O side chains
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?
additional information
?
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bifunctional enzyme with phosphoglucomutase, EC 5.4.2.2, and phosphomannomutase activities
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?
additional information
?
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bifunctional enzyme with phosphoglucomutase and phosphomannomutase, EC 5.4.2.8, activities, the catalytic efficiency is about 15fold higher for glucose 1-phosphate than for mannose 1-phosphate
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?
additional information
?
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bifunctional enzyme with phosphoglucomutase and phosphomannomutase, EC 5.4.2.8, activities, the catalytic efficiency is about 15fold higher for glucose 1-phosphate than for mannose 1-phosphate
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?
additional information
?
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bifunctional enzyme with phosphoglucomutase and phosphomannomutase, EC 5.4.2.8, activities, the catalytic efficiency is about 15fold higher for glucose 1-phosphate than for mannose 1-phosphate
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?
additional information
?
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the enzyme exhibits the function of phosphoglucomutase, EC 5.4.2.2, whose gene is lost in Trypanosoma brucei, together with phosphomannomutase, EC 5.4.2.8, producing D-glucose 1-phosphate from D-glucose 6-phosphate, kinetics, overview
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?
additional information
?
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the enzyme exhibits the function of phosphoglucomutase, EC 5.4.2.2, whose gene is lost in Trypanosoma brucei, together with phosphomannomutase, EC 5.4.2.8, producing D-glucose 1-phosphate from D-glucose 6-phosphate, kinetics, overview
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?
additional information
?
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the enzyme exhibits the function of phosphoglucomutase, EC 5.4.2.2, whose gene is lost in Trypanosoma brucei, together with phosphomannomutase, EC 5.4.2.8, producing D-glucose 1-phosphate from D-glucose 6-phosphate, kinetics, overview
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?
