5.4.2.8: phosphomannomutase
This is an abbreviated version!
For detailed information about phosphomannomutase, go to the full flat file.
Word Map on EC 5.4.2.8
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5.4.2.8
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carbohydrate-deficient
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transferrin
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gdp-mannose
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multisystemic
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cdg-ia
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team
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mannose-1-phosphate
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pectoralis
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phosphoglucomutase
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doctors
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obstetric
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hypoglycosylation
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nipple
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lipid-linked
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psoas
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premammillary
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strabismus
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paromomycin
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meniscectomy
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medicine
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food industry
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biotechnology
- 5.4.2.8
-
carbohydrate-deficient
- transferrin
- gdp-mannose
-
multisystemic
-
cdg-ia
-
team
- mannose-1-phosphate
-
pectoralis
- phosphoglucomutase
-
doctors
-
obstetric
-
hypoglycosylation
-
nipple
-
lipid-linked
-
psoas
-
premammillary
-
strabismus
- paromomycin
-
meniscectomy
- medicine
- food industry
- biotechnology
Reaction
Synonyms
alpha-D-phosphohexomutase, alpha-phosphomannomutase1, EC 2.7.5.7, IMP-sensitive glucose-1,6-bisphosphatase, ManB, ORF17, PGM/PMM, PGM2, PgmG, phosphoglucomutase/phosphomannomutase, Phosphohexomutase, phosphomannomutase, phosphomannomutase 1, phosphomannomutase 2, phosphomannomutase/phosphoglucomutase, phosphomannomutase2, Phosphomannose mutase, Phosphomutase, mannose, PMM, PMM-1, PMM-2, PMM-A1, PMM-A2, PMM-B1, PMM-B2, PMM-D1, PMM-D2, PMM/PGM, PMM1, PMM2, PMMH-22, SP-2, SSO0207
ECTree
5.4.2.8 phosphomannomutaseAdvanced search results
results (
results (Engineering
Engineering on EC 5.4.2.8 - phosphomannomutase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
G7R/R37Q
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temperature-sensitive Arabidopsis thaliana PMM-12 mutant (G7R/R37Q) has lower PMM protein and enzyme activity levels than the wild type enzyme
C241S
the mutant shows 60% residual activity the mutation is associated with phosphomannomutase 2 deficiency
D188G |
mutant of isoform PMM2, 2% of wild-type activiy, involved in congential disorder of glycosylation type 1a
D209G
inactive, the mutation is associated with phosphomannomutase 2 deficiency
D65Y
F119L
F157S
inactive, the mutation is associated with phosphomannomutase 2 deficiency
F207S
inactive, the mutation is associated with phosphomannomutase 2 deficiency
L32R
the mutant shows 45% residual activity the mutation is associated with phosphomannomutase 2 deficiency
P113L
the mutant shows 43% residual activity, the mutation is associated with phosphomannomutase 2 deficiency
P184T
inactive, the mutation is associated with phosphomannomutase 2 deficiency
R123Q
inactive, the mutation is associated with phosphomannomutase 2 deficiency
R141H
R162W
mutant of isoform PMM2, involved in congential disorder of glycosylation type 1a
T118S
the mutant shows 1% residual activity the mutation is associated with phosphomannomutase 2 deficiency
T237M
the mutant shows 48% residual activity the mutation is associated with phosphomannomutase 2 deficiency
V129M
mutant of isoform PMM2, involved in congential disorder of glycosylation type 1a
V231M
mutant of isoform PMM2, loss of stability at 40°C, involved in congential disorder of glycosylation type 1a
V44A
the mutant shows 16% residual activity the mutation is associated with phosphomannomutase 2 deficiency
N110A
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no remarkable differences in Km and Vmax value compared to wild-type, but intermediate glucose-1,6-bisphosphate dissociates from mutant 25times more often than from wild-type
R15A
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no remarkable differences in Km and Vmax value compared to wild-type, but intermediate glucose-1,6-bisphosphate dissociates from mutant 25times more often than from wild-type
R20A
R247A
S101A
DELTAmanAB
phosphomannose isomerase, phosphomannosemutase double mutant
additional information
D65Y
mutant of isoform PMM2, involved in congential disorder of glycosylation type 1a
D65Y
the mutant shows 20% residual activity the mutation is associated with phosphomannomutase 2 deficiency
F119L
mutant of isoform PMM2, involved in congential disorder of glycosylation type 1a
R141H
mutant of isoform PMM2, 0.4% of wild-type activiy, involved in congential disorder of glycosylation type 1a
R141H
inactive, the mutation is associated with phosphomannomutase 2 deficiency
R141H
the mutation lowers activity to approximately one hundredth of that of wild type enzyme
R247A
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no remarkable differences in Km and Vmax value compared to wild-type, modest increase in dissociation of intermediate glucose-1,6-bisphosphate from enzyme
S101A
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mutant protein PH0923S101A to investigate the role of the serine residue
S101A
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mutant protein PH0923S101A to investigate the role of the serine residue
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additional information
expression as green fluorescent protein fusion protein in Arabidospsis thaliana increases ascorbic acid content by 25-33%
additional information
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expression in Leishmania mexicana does not restore virulence of an enzyme deletion mutant
additional information
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reducing enzyme expression level through virus-induced gene silencing causes substantial decrease in ascorbic acid content in leaves. Raising the expression level leads to 20-50% increase in ascorbic acid content
additional information
RNAi knockdown of gene TbPMM, construction of a cell line expressing tetracycline inducible double-stranded RNA targeting TbPMM, induction of dsRNA targeting TbPMM results in a 68% knockdown of TbPMM mRNA after 48 h and a reduction of growth rate that leads to cell death after 72 h, phenotypes, overview
additional information
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RNAi knockdown of gene TbPMM, construction of a cell line expressing tetracycline inducible double-stranded RNA targeting TbPMM, induction of dsRNA targeting TbPMM results in a 68% knockdown of TbPMM mRNA after 48 h and a reduction of growth rate that leads to cell death after 72 h, phenotypes, overview
additional information
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RNAi knockdown of gene TbPMM, construction of a cell line expressing tetracycline inducible double-stranded RNA targeting TbPMM, induction of dsRNA targeting TbPMM results in a 68% knockdown of TbPMM mRNA after 48 h and a reduction of growth rate that leads to cell death after 72 h, phenotypes, overview
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