5.4.2.3: phosphoacetylglucosamine mutase

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For detailed information about phosphoacetylglucosamine mutase, go to the full flat file.

Word Map on EC 5.4.2.3

5.4.2.3

udp-n-acetylglucosamine

phosphoglucomutase

pyrophosphorylase

mutases

udp-glcnac

glcnac-6-p

phosphoglucosamine

phosphoserine

synthesis

Reaction

N-acetyl-alpha-D-glucosamine 1-phosphate

Synonyms

2-Acetamido-2-deoxy-D-glucose-1,6-bisphosphate:2-acetamido-2-deoxy-D-glucose 1-phosphate phosphotransferase, Acetylaminodeoxyglucose phosphomutase, Acetylglucosamine phosphomutase, AGM, AGM1, AGM1/PGM3, CaAGM1, DNA-damage-repair/toleration protein DRT101, EC 2.7.5.2, EC 2.7.5.2., HsAGM1, N-acetylglucosamine-phosphate mutase, PAGM, PGlcNAc mutase, PGM3, Phospho-N-acetylglucosamine mutase, phosphoacetylglucosamine mutase 1, Phosphomutase, acetylglucosamine

ECTree

5 Isomerases

5.4 Intramolecular transferases

5.4.2 Phosphotransferases (phosphomutases)

5.4.2.3 phosphoacetylglucosamine mutase

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Results	in table
12	Activating Compound
3255	AA Sequence
1	Application
1	CAS Registry Number
7	Cloned(Commentary)
2	Crystallization (Commentary)
7	General Information
1	General Stability
2	IC50 Value
19	Inhibitors
2	kcat/KM [mM/s]
11	KM Value [mM]
5	Localization
6	Metals/Ions
4	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
22	Organism
5	Pathway
12	PDB ID
9	pH Optimum
2	pH Range
25	Protein Variants
9	Purification (Commentary)
3	Reaction
2	Reaction Type
22	Reference
27	Source Tissue
2	Specific Activity [micromol/min/mg]
4	Storage Stability
38	Substrates and Products (Substrate)
2	Subunits
22	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
3	Turnover Number [1/s]

General Information

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General Information on EC 5.4.2.3 - phosphoacetylglucosamine mutase

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evolution

2 entries

malfunction

Drosophila melanogaster

Q9VTZ4

loss-of-function mutations in the nst gene, which encodes PGM3, block fibroblast growth factor signaling during embryonic mesoderm and tracheal development. In nst mutants with an 80% reduction in the amount of UDP-GlcNAc, O-GlcNAcylation is compromised. Embryos maternally and zygotically mutant for nst exhibit defects in mesoderm layer formation during gastrulation that are similar to those observed in embryos with mutations in the gene encoding the fibroblast growth factor receptor Heartless (Htl). Zygotic nst mutants (nstZ) exhibit normal dorsal mesoderm differentiation, embryos homozygous for the hypomorphic htlYY262 allele show a reduction in dorsal mesoderm. Phenotypes, overview. Dof is the critical component in MAPK activation affected in nst mutants

728799

metabolism

Drosophila melanogaster

Q9VTZ4

Nst acts downstream of fibroblast growth factor receptor signaling

728799

physiological function

3 entries