5.4.2.2: phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
This is an abbreviated version!
For detailed information about phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent), go to the full flat file.
Word Map on EC 5.4.2.2
-
5.4.2.2
-
starch
-
hexokinase
-
glycogen
-
malate
-
phosphorylase
-
6-phosphogluconate
-
pyrophosphorylase
-
1-phosphate
-
adenylate
-
esterase
-
erythrocyte
-
galactose
-
glucose-1-phosphate
-
aldolase
-
phosphofructokinase
-
transferrin
-
gpi
-
allozyme
-
haptoglobin
-
malic
-
glucosephosphate
-
zymodemes
-
histolytica
-
hardy-weinberg
-
entamoeba
-
glyoxalase
-
adp-glucose
-
phosphoglucoisomerase
-
glucose-6-phosphatase
-
monomorphic
-
plastidial
-
glycogenolysis
-
fructokinase
-
diptera
-
galactose-1-phosphate
-
phosphohexose
-
starch-gel
-
uridylyltransferase
-
5.3.1.9
-
glc-6-p
-
bloodstain
-
udp-galactose
-
leloir
-
amyloplasts
-
duffy
-
udp-glc
-
phosphoenzyme
-
isoenzymatic
-
2.7.1.1
-
1,6-diphosphate
-
drug development
-
molecular biology
-
food industry
-
medicine
- 5.4.2.2
- starch
- hexokinase
- glycogen
- malate
- phosphorylase
- 6-phosphogluconate
-
pyrophosphorylase
- 1-phosphate
- adenylate
- esterase
- erythrocyte
- galactose
- glucose-1-phosphate
- aldolase
-
phosphofructokinase
- transferrin
- gpi
-
allozyme
- haptoglobin
-
malic
-
glucosephosphate
-
zymodemes
- histolytica
-
hardy-weinberg
- entamoeba
- glyoxalase
- adp-glucose
- phosphoglucoisomerase
- glucose-6-phosphatase
-
monomorphic
- plastidial
-
glycogenolysis
- fructokinase
- diptera
- galactose-1-phosphate
-
phosphohexose
-
starch-gel
-
uridylyltransferase
-
5.3.1.9
-
glc-6-p
-
bloodstain
- udp-galactose
-
leloir
- amyloplasts
-
duffy
- udp-glc
- phosphoenzyme
-
isoenzymatic
-
2.7.1.1
- 1,6-diphosphate
- drug development
- molecular biology
- food industry
- medicine
Reaction
Synonyms
alpha phosphoglucomutase, alpha-Pgm, alpha-phosphoglucomutase, alpha-phosphoglucomutase 1, alpha-phosphoglucose mutase, cPGM, cytosolic phosphoglucomutase, EC 2.7.5.1, Glucose phosphomutase, PGM, PGM-I, PGM-II, PGM/PMM, PGM1, PGM2, PGM3, PgmA, PgmG, phospho-glucomutase, phosphoglucomutase, phosphoglucomutase 1, phosphoglucomutase/phosphomannomutase, phosphoglucomutase1, Phosphoglucose mutase, Phosphohexomutase, phosphomannomutase/phosphoglucomutase, Phosphomutase, glucose, plastidic phosphoglucomutase, PMM/PGM, pPGM, SP-1, SpgM, SSO0207, XanA, YMR278w protein
ECTree
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)Advanced search results
results (
results (Substrates Products
Substrates Products on EC 5.4.2.2 - phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
alpha-D-glucose 6-phosphate
alpha-D-glucose 1-phosphate
23% of the activity with alpha-D-glucose 1-phosphate
-
-
r
D-fructose-1-phosphate
D-fructose-6-phosphate
-
no mutase activity
-
-
?
D-glucosamine-1-phosphate
D-glucosamine-6-phosphate
-
low enzyme activity
-
-
?
D-glucose 1-phosphate + D-fructose 1,6-diphosphate
D-glucose 1,6-diphosphate + D-fructose 1-phosphate + D-fructose 6-phosphate
-
synthesis of glucose 1,6-diphosphate is an additional activity
synthesis of glucose 1,6-diphosphate is an additional activity
?
Glucose 1-phosphate + 1,3-bisphosphoglycerate
Glucose 1,6-diphosphate + glycerate 3-phosphate
-
synthesis of glucose 1,6-diphosphate is an additional activity
synthesis of glucose 1,6-diphosphate is an additional activity
?
N-acetyl-D-glucosamine-1-phosphate
N-acetyl-D-glucosamine-6-phosphate
-
no mutase activity
-
-
?
alpha-D-glucose 1,6-bisphosphate + H2O
alpha-D-glucose 6-phosphate + phosphate
-
-
-
-
?
alpha-D-glucose 1,6-bisphosphate + H2O
alpha-D-glucose 6-phosphate + phosphate
-
-
-
-
?
alpha-D-glucose 1-phosphate
?
-
key enzyme in carbohydrate metabolism
-
-
?
alpha-D-glucose 1-phosphate
?
-
degradation of lactose in lactic acid bacteria
-
-
?
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
-
-
r
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
-
-
?
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
the beta-form is inactive
-
?
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
enzyme is highly specific for substrate and product
-
-
r
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
the forward reaction is faster than the reverse reaction
-
?
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
the beta-form is inactive
-
?
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
-
r
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
-
r
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
r
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
-
-
?
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
-
-
?
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
-
?
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
-
r
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
-
r
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
SP-1 shows preference for glucose-1-phosphate rather than mannose-1-phosphate
-
-
?
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
SP-1 shows preference for glucose-1-phosphate rather than mannose-1-phosphate
-
-
?
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
-
?
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
-
?
alpha-D-glucose 1-phosphate
D-glucose 6-phosphate
-
-
-
r
alpha-D-glucose 1-phosphate
D-glucose 6-phosphate
it is unclear whether either glucose or mannose phosphate represents the cellular substrate for SsoPHM. The Km values for rSsoPHM toward glucose 6-phosphate and mannose 6-phosphate are in the low millimolar range, significantly higher than that expected for a physiological substrate. Since the protein encoded by sso0207 is the only identifiable phosphohexomutase in the Sulfolbus solfataricus P2 genome, SsoPHM provides the only recognizable avenue for interconverting glucose 6-phosphate and glucose 1-phosphate during glycogen synthesis and breakdown
-
-
r
alpha-D-glucose 1-phosphate
D-glucose 6-phosphate
the enzyme also catalyzes the interconversion of alpha-D-mannose 1-phosphate and D-mannose 6-phosphate
-
-
r
alpha-D-glucose 1-phosphate
D-glucose 6-phosphate
it is unclear whether either glucose or mannose phosphate represents the cellular substrate for SsoPHM. The Km values for rSsoPHM toward glucose 6-phosphate and mannose 6-phosphate are in the low millimolar range, significantly higher than that expected for a physiological substrate. Since the protein encoded by sso0207 is the only identifiable phosphohexomutase in the Sulfolbus solfataricus P2 genome, SsoPHM provides the only recognizable avenue for interconverting glucose 6-phosphate and glucose 1-phosphate during glycogen synthesis and breakdown
-
-
r
alpha-D-glucose 1-phosphate
D-glucose 6-phosphate
the enzyme also catalyzes the interconversion of alpha-D-mannose 1-phosphate and D-mannose 6-phosphate
-
-
r
alpha-D-glucose 1-phosphate
D-glucose 6-phosphate
-
-
-
?
alpha-D-glucose 1-phosphate
D-glucose 6-phosphate
-
-
-
?
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
-
-
-
r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
-
-
-
r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
-
-
r
alpha-D-mannose 1-phosphate
D-mannose-6-phosphate
SP-1 shows preference for glucose-1-phosphate rather than mannose-1-phosphate
-
-
?
alpha-D-mannose 1-phosphate
D-mannose-6-phosphate
SP-1 shows preference for glucose-1-phosphate rather than mannose-1-phosphate
-
-
?
D-glucose 6-phosphate
alpha-D-glucose 1-phosphate
it is unclear whether either glucose or mannose phosphate represents the cellular substrate for SsoPHM. The Km values for rSsoPHM toward glucose 6-phosphate and mannose 6-phosphate are in the low millimolar range, significantly higher than that expected for a physiological substrate. Since the protein encoded by sso0207 is the only identifiable phosphohexomutase in the Sulfolbus solfataricus P2 genome, SsoPHM provides the only recognizable avenue for interconverting glucose 6-phosphate and glucose 1-phosphate during glycogen synthesis and breakdown
-
-
r
D-glucose 6-phosphate
alpha-D-glucose 1-phosphate
the enzyme also catalyzes the interconversion of alpha-D-mannose 1-phosphate and D-mannose 6-phosphate. No activity toward glucosamine 6-phosphate or N-acetylglucosamine 6-phosphate
-
-
r
D-glucose 6-phosphate
alpha-D-glucose 1-phosphate
it is unclear whether either glucose or mannose phosphate represents the cellular substrate for SsoPHM. The Km values for rSsoPHM toward glucose 6-phosphate and mannose 6-phosphate are in the low millimolar range, significantly higher than that expected for a physiological substrate. Since the protein encoded by sso0207 is the only identifiable phosphohexomutase in the Sulfolbus solfataricus P2 genome, SsoPHM provides the only recognizable avenue for interconverting glucose 6-phosphate and glucose 1-phosphate during glycogen synthesis and breakdown
-
-
r
D-glucose 6-phosphate
alpha-D-glucose 1-phosphate
the enzyme also catalyzes the interconversion of alpha-D-mannose 1-phosphate and D-mannose 6-phosphate. No activity toward glucosamine 6-phosphate or N-acetylglucosamine 6-phosphate
-
-
r
D-glucose-1-phosphate
D-glucose-6-phosphate
-
bifunctional enzyme
-
-
?
D-mannose-1-phosphate
D-mannose-6-phosphate
-
bifunctional enzyme
-
-
?
Glucose 6-phosphate
?
-
synthesis of glucose 1-phosphate for the formation of UDPglucose
-
-
?
additional information
?
-
-
PGM from Clostridium thermocellum is a dual-specificity enzyme with phosphoglucomutase and phosphomannomutase activities
-
-
?
additional information
?
-
-
isozyme PGM2 also displays activities of phosphoribomutase and glucose 1,6-bisphosphate synthase
-
-
?
additional information
?
-
-
isozyme PGM2 also displays activities of phosphoribomutase and glucose 1,6-bisphosphate synthase
-
-
?
additional information
?
-
no substrate: alpha-D-mannose 1-phosphate, beta-D-glucose 1-phosphate
-
-
?
additional information
?
-
-
no substrate: alpha-D-mannose 1-phosphate, beta-D-glucose 1-phosphate
-
-
?
additional information
?
-
-
bifunctional enzyme with phosphoglucomutase and phosphomannomutase, EC 5.4.2.8, activities
-
-
?
additional information
?
-
-
bifunctional enzyme with phosphoglucomutase and phosphomannomutase, EC 5.4.2.8, activities. Strongly conserved residue His329 in the active site is critical for enzyme activity. His329 is appropriately positioned to abstract a proton from the O1/O6 hydroxyl of the phosphosugar substrates, and thus may serve as the general base in the reaction
-
-
?
additional information
?
-
-
no activity with alpha-D-ribose 5-phosphate
-
-
?
additional information
?
-
-
Pgm3 functions as the major phosphoribomutase in vivo
-
-
?
additional information
?
-
-
phosphoglucomutases Pgm1, Pgm2, and Pgm3, EC 5.4.2.2, of Saccharomyces cerevisiae show ability to interconvert ribose-1-phosphate and ribose-5-phosphate. The purified proteins, studied in vitro with regard to their kinetic properties on glucose-1-phosphate and ribose-1-phosphate, are all active on both substrates with Pgm1 exhibiting only residual activity on ribose-1-phosphate. The Pgm2 and Pgm3 proteins have almost equal kinetic properties on ribose-1-phosphate, but Pgm2 has a 2000times higher preference for glucose-1-phosphate when compared to Pgm3
-
-
?
additional information
?
-
-
no activity with alpha-D-ribose 5-phosphate
-
-
?
additional information
?
-
bifunctional enzyme with phosphoglucomutase and phosphomannomutase, EC 5.4.2.8, activities, the catalytic efficiency is about 15fold higher for glucose 1-phosphate than for mannose 1-phosphate
-
-
?
additional information
?
-
-
bifunctional enzyme with phosphoglucomutase and phosphomannomutase, EC 5.4.2.8, activities, the catalytic efficiency is about 15fold higher for glucose 1-phosphate than for mannose 1-phosphate
-
-
?
additional information
?
-
bifunctional enzyme with phosphoglucomutase and phosphomannomutase, EC 5.4.2.8, activities, the catalytic efficiency is about 15fold higher for glucose 1-phosphate than for mannose 1-phosphate
-
-
?
