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5.4.2.2: phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)

This is an abbreviated version!
For detailed information about phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent), go to the full flat file.

Word Map on EC 5.4.2.2

Reaction

alpha-D-glucose 1-phosphate
=
D-glucose 6-phosphate

Synonyms

alpha phosphoglucomutase, alpha-Pgm, alpha-phosphoglucomutase, alpha-phosphoglucomutase 1, alpha-phosphoglucose mutase, cPGM, cytosolic phosphoglucomutase, EC 2.7.5.1, Glucose phosphomutase, PGM, PGM-I, PGM-II, PGM/PMM, PGM1, PGM2, PGM3, PgmA, PgmG, phospho-glucomutase, phosphoglucomutase, phosphoglucomutase 1, phosphoglucomutase/phosphomannomutase, phosphoglucomutase1, Phosphoglucose mutase, Phosphohexomutase, phosphomannomutase/phosphoglucomutase, Phosphomutase, glucose, plastidic phosphoglucomutase, PMM/PGM, pPGM, SP-1, SpgM, SSO0207, XanA, YMR278w protein

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.2 Phosphotransferases (phosphomutases)
                5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)

Engineering

Engineering on EC 5.4.2.2 - phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A139T
disease-associated missense variant
D263G
D263Y
D288G
disease-associated missense variant
D62H
disease-associated missense variant
E377K
disease-associated missense variant
E388K
disease-associated missense variant
G121R
disease-associated missense variant
G121W
disease-associated missense variant
G230E
disease-associated missense variant
G291R
disease-associated missense variant
G330R
disease-associated missense variant
G375V
disease-associated missense variant
G380R
disease-associated missense variant
G506S
disease-associated missense variant
G508R
disease-associated missense variant
G511R
disease-associated missense variant
H261D
disease-associated missense variant
L516P
disease-associated missense variant
N38Y
disease-associated missense variant
P336R
disease-associated missense variant
Q41E
disease-associated missense variant
Q41H
disease-associated missense variant
Q41R
disease-associated missense variant
R422Q
disease-associated missense variant
R422W
disease-associated missense variant
R503Q
disease-associated missense variant
R515L
disease-associated missense variant
R515Q
disease-associated missense variant
R515W
disease-associated missense variant
S505R
disease-associated missense variant
T115A
disease-associated missense variant
T19A
disease-associated missense variant
T337M
disease-associated missense variant
T556A
the mutant shows about wild type activity
T556E
the mutant shows about wild type activity
T559A
the mutant shows about wild type activity
T559E
the mutant shows about wild type activity
T562A
the mutant shows slightly reduced activity compared to the wild type enzyme
T562E
the mutant shows strongly reduced activity compared to the wild type enzyme
H109Q
6% of wild-type activity
H308N
100% of wild-type activity
H308N/H329N
5% of wild-type activity
H329A
-
site-directed mutagenesis, crystal structure determination and comparison, the mutant shows no significant changes from the wild-type enzyme, excluding structural disruption as the source of its compromised activity. The kcat of the mutant is 3000fold reduced relative to the wild-type enzyme
H329N
6% of wild-type activity
K118L
4% of wild-type activity
K118L/H109Q
5% of wild-type activity
N110A
-
no remarkable differences in Km and Vmax value compared to wild-type, but intermediate glucose-1,6-bisphosphate dissociates from mutant 25times more often than from wild-type
R15A
-
no remarkable differences in Km and Vmax value compared to wild-type, but intermediate glucose-1,6-bisphosphate dissociates from mutant 25times more often than from wild-type
R241C
-
0.3% of wild-type acivity, with Km value similar to wild-type
R247A
S108A
12% of wild-type activity
S108A/H109Q
6% of wild-type activity
S108A/H308N
3% of wild-type activity
S108A/H329N
no activity
S108D
7% of wild-type activity
S108V
1% of wild-type activity
S101A
S309A
activity of mutant enzyme with D-glucose 6-phosphate is 58% compared to activity of wild-type enzyme
S309D
activity of mutant enzyme with D-glucose 6-phosphate is 4% compared to activity of wild-type enzyme
S309N
activity of mutant enzyme with D-glucose 6-phosphate is 27% compared to activity of wild-type enzyme
S309Q
activity of mutant enzyme with D-glucose 6-phosphate is 22% compared to activity of wild-type enzyme
S309T
activity of mutant enzyme with D-glucose 6-phosphate is 36% compared to activity of wild-type enzyme
S309V
activity of mutant enzyme with D-glucose 6-phosphate is 36% compared to activity of wild-type enzyme
S309A
-
activity of mutant enzyme with D-glucose 6-phosphate is 58% compared to activity of wild-type enzyme
-
S309N
-
activity of mutant enzyme with D-glucose 6-phosphate is 27% compared to activity of wild-type enzyme
-
S309Q
-
activity of mutant enzyme with D-glucose 6-phosphate is 22% compared to activity of wild-type enzyme
-
S309T
-
activity of mutant enzyme with D-glucose 6-phosphate is 36% compared to activity of wild-type enzyme
-
S309V
-
activity of mutant enzyme with D-glucose 6-phosphate is 36% compared to activity of wild-type enzyme
-
S158T
additional information