5.4.2.2: phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
This is an abbreviated version!
For detailed information about phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent), go to the full flat file.
Word Map on EC 5.4.2.2
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5.4.2.2
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starch
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hexokinase
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glycogen
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malate
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phosphorylase
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6-phosphogluconate
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pyrophosphorylase
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1-phosphate
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adenylate
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esterase
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erythrocyte
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galactose
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glucose-1-phosphate
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aldolase
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phosphofructokinase
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transferrin
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gpi
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allozyme
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haptoglobin
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malic
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glucosephosphate
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zymodemes
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histolytica
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hardy-weinberg
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entamoeba
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glyoxalase
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adp-glucose
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phosphoglucoisomerase
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glucose-6-phosphatase
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monomorphic
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plastidial
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glycogenolysis
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fructokinase
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diptera
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galactose-1-phosphate
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phosphohexose
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starch-gel
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uridylyltransferase
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5.3.1.9
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glc-6-p
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bloodstain
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udp-galactose
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leloir
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amyloplasts
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duffy
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udp-glc
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phosphoenzyme
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isoenzymatic
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2.7.1.1
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1,6-diphosphate
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drug development
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molecular biology
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food industry
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medicine
- 5.4.2.2
- starch
- hexokinase
- glycogen
- malate
- phosphorylase
- 6-phosphogluconate
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pyrophosphorylase
- 1-phosphate
- adenylate
- esterase
- erythrocyte
- galactose
- glucose-1-phosphate
- aldolase
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phosphofructokinase
- transferrin
- gpi
-
allozyme
- haptoglobin
-
malic
-
glucosephosphate
-
zymodemes
- histolytica
-
hardy-weinberg
- entamoeba
- glyoxalase
- adp-glucose
- phosphoglucoisomerase
- glucose-6-phosphatase
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monomorphic
- plastidial
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glycogenolysis
- fructokinase
- diptera
- galactose-1-phosphate
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phosphohexose
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starch-gel
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uridylyltransferase
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5.3.1.9
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glc-6-p
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bloodstain
- udp-galactose
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leloir
- amyloplasts
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duffy
- udp-glc
- phosphoenzyme
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isoenzymatic
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2.7.1.1
- 1,6-diphosphate
- drug development
- molecular biology
- food industry
- medicine
Reaction
Synonyms
alpha phosphoglucomutase, alpha-Pgm, alpha-phosphoglucomutase, alpha-phosphoglucomutase 1, alpha-phosphoglucose mutase, cPGM, cytosolic phosphoglucomutase, EC 2.7.5.1, Glucose phosphomutase, PGM, PGM-I, PGM-II, PGM/PMM, PGM1, PGM2, PGM3, PgmA, PgmG, phospho-glucomutase, phosphoglucomutase, phosphoglucomutase 1, phosphoglucomutase/phosphomannomutase, phosphoglucomutase1, Phosphoglucose mutase, Phosphohexomutase, phosphomannomutase/phosphoglucomutase, Phosphomutase, glucose, plastidic phosphoglucomutase, PMM/PGM, pPGM, SP-1, SpgM, SSO0207, XanA, YMR278w protein
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Engineering
Engineering on EC 5.4.2.2 - phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
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D263G
D263Y
T562A
the mutant shows slightly reduced activity compared to the wild type enzyme
T562E
the mutant shows strongly reduced activity compared to the wild type enzyme
H329A
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site-directed mutagenesis, crystal structure determination and comparison, the mutant shows no significant changes from the wild-type enzyme, excluding structural disruption as the source of its compromised activity. The kcat of the mutant is 3000fold reduced relative to the wild-type enzyme
N110A
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no remarkable differences in Km and Vmax value compared to wild-type, but intermediate glucose-1,6-bisphosphate dissociates from mutant 25times more often than from wild-type
R15A
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no remarkable differences in Km and Vmax value compared to wild-type, but intermediate glucose-1,6-bisphosphate dissociates from mutant 25times more often than from wild-type
R20A
R247A
S101A
S309A
activity of mutant enzyme with D-glucose 6-phosphate is 58% compared to activity of wild-type enzyme
S309D
activity of mutant enzyme with D-glucose 6-phosphate is 4% compared to activity of wild-type enzyme
S309N
activity of mutant enzyme with D-glucose 6-phosphate is 27% compared to activity of wild-type enzyme
S309Q
activity of mutant enzyme with D-glucose 6-phosphate is 22% compared to activity of wild-type enzyme
S309T
activity of mutant enzyme with D-glucose 6-phosphate is 36% compared to activity of wild-type enzyme
S309V
activity of mutant enzyme with D-glucose 6-phosphate is 36% compared to activity of wild-type enzyme
S309A
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activity of mutant enzyme with D-glucose 6-phosphate is 58% compared to activity of wild-type enzyme
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S309N
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activity of mutant enzyme with D-glucose 6-phosphate is 27% compared to activity of wild-type enzyme
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S309Q
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activity of mutant enzyme with D-glucose 6-phosphate is 22% compared to activity of wild-type enzyme
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S309T
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activity of mutant enzyme with D-glucose 6-phosphate is 36% compared to activity of wild-type enzyme
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S309V
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activity of mutant enzyme with D-glucose 6-phosphate is 36% compared to activity of wild-type enzyme
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S158T
additional information
R247A
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no remarkable differences in Km and Vmax value compared to wild-type, modest increase in dissociation of intermediate glucose-1,6-bisphosphate from enzyme
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mutant protein PH0923S101A to investigate the role of the serine residue
S101A
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mutant protein PH0923S101A to investigate the role of the serine residue
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recombinant expression of plastidial phosphoglucomutase in Nicotiana tabacum cv. Xanthi stimulates photosynthetic carbon flow into starch synthesis
additional information
overproduction of enzyme leads to increased glycolytic flux and growth rate on galactose. Growth of a conditional knock-out strain is severely impaired when enzyme activity is below the control level
additional information
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overproduction of enzyme leads to increased glycolytic flux and growth rate on galactose. Growth of a conditional knock-out strain is severely impaired when enzyme activity is below the control level
additional information
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overexpression of phosphoglucomutase gene PGM1 is able to suppress the growth-deficiency of mutant RAS2val19 that is unable to grow on galactose as the sole source of carbon. Elevated levels of enzyme allow for the more efficient utilization of the limiting levels of glucose 1-phosphate that are present in the RASval19 mutant