5.4.2.12: phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
This is an abbreviated version!
For detailed information about phosphoglycerate mutase (2,3-diphosphoglycerate-independent), go to the full flat file.
Word Map on EC 5.4.2.12
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5.4.2.12
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mutases
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2-phosphoglycerate
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ipgms
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2,3-bisphosphoglycerate-independent
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cofactor-dependent
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2,3-bisphosphoglycerate
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mexicana
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brugia
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malayi
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phosphoenzyme
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dikinase
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flux-controlling
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filariasis
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medicine
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drug development
- 5.4.2.12
- mutases
- 2-phosphoglycerate
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ipgms
-
2,3-bisphosphoglycerate-independent
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cofactor-dependent
- 2,3-bisphosphoglycerate
- mexicana
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brugia
- malayi
- phosphoenzyme
- dikinase
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flux-controlling
- filariasis
- medicine
- drug development
Reaction
Synonyms
2,3-biphosphoglycerate-independent phosphoglycerate mutase, 2,3-diphosphoglycerate-independent phosphoglycerate mutase, 2,3BPG-independent PGAM, 3-phosphoglycerate mutase, apgM, co-factor-independent phosphoglycerate mutase, cofactor independent phosphoglycerate mutase, cofactor-independent phosphoglycerate mutase, cofactor-independent phosphoglycerate mutase 1, EC 2.7.5.3, EC 5.4.2.1, independent PGAM, independent PGM, iPGAM, iPGM, MJ0010, MJ1612, PGAM, PGM, PH0037, SSO0417
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Inhibitors
Inhibitors on EC 5.4.2.12 - phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
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1-methyl-2-(methylthio)-1H-benzimidazole-5-carboxamide
54% inhibition at 0.1 mM
1-methyl-2-(methylthio)-N-(5-nitro-1,3-thiazol-2-yl)-1H-benzimidazole-6-carboxamide
47% inhibition at 0.1 mM
2-(4-nitrophenyl)-1H-benzimidazole-7-carboxylic acid
56% inhibition at 0.1 mM
6-chloro-2-(4-nitrophenyl)-1H-benzimidazole-7-carboxylic acid
59% inhibition at 0.1 mM
6-chloro-2-(methylthio)-1H-benzimidazole-5-carboxylic acid
73% inhibition at 0.1 mM
6-chloro-2-(methylthio)-N-(5-nitro-1,3-thiazol-2-yl)-1H-benzimidazole-5-carboxamide
47% inhibition at 0.1 mM
diethyl dicarbonate
irreversible inhibition, saturating concentrations of substrate protect
vanadate
up to 0.1 mM, 90% maximal inhibition. Inhibition may be partially reversed by EDTA
EDTA
1 mM, 10% residual activity at pH 8.0, reversible by incubation with CoCl2, but not MnCl2, FeSO4, CuSo4, NiCl2, ZnCl2
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0.01 mM and 0.1 mM, 50% and 90% inhibition of phosphoglycerate mutase activity, respectively
additional information
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no influence on activity: DL-sulfolactate, L-sulfolactate, dihydroxyacetone phosphate, DL-glycerate, DL-alpha-glycerophosphate, 3-hydroxypropionate, L-lactate, 3-mercaptopropionate, 2-mercaptopropionate, phosphoenolpyruvate, O-phosphoserine, DL-o-phosphothreonine, propionate, Li+, Ca2+, Co2+, Mg2+, Fe3+, Cr3+
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additional information
not inhibitory: vanadate, cloride, sulfate
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additional information
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no influence on activity: fructose 6-phosphate, fructose 1,6-bisphosphate, glucose 6-phosphate, citric acid, malate, glyoxylate, phosphoenolpyruvate, pyruvate, phosphoglycolate, glyceric acid, alpha-glycerophosphate, iodoacetamide, Gly, Ser, diphosphate, 2,3-diglycerophosphate
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