5.4.2.11: phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)
This is an abbreviated version!
For detailed information about phosphoglycerate mutase (2,3-diphosphoglycerate-dependent), go to the full flat file.
Word Map on EC 5.4.2.11
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5.4.2.11
-
enolase
-
aldolase
-
isozyme
-
2-phosphoglycerate
-
glyceraldehyde-3-phosphate
-
glycogen
-
creatine
-
mutases
-
triosephosphate
-
phosphofructokinase
-
muscle-specific
-
cofactor-independent
-
cramp
-
myoglobinuria
-
triose
-
bb
-
fructose-2,6-bisphosphatase
-
phosphohistidine
-
tpi
-
warburg
-
phosphoenzyme
-
fructose-bisphosphate
-
aldoa
-
brugia
-
malayi
-
medicine
-
biofuel production
-
drug development
- 5.4.2.11
- enolase
- aldolase
- isozyme
- 2-phosphoglycerate
- glyceraldehyde-3-phosphate
- glycogen
- creatine
- mutases
-
triosephosphate
-
phosphofructokinase
-
muscle-specific
-
cofactor-independent
- cramp
- myoglobinuria
- triose
- bb
- fructose-2,6-bisphosphatase
-
phosphohistidine
- tpi
-
warburg
- phosphoenzyme
-
fructose-bisphosphate
- aldoa
-
brugia
- malayi
- medicine
- biofuel production
- drug development
Reaction
Synonyms
2,3-bisphosphoglycerate-dependent PGAM, 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, alpha-PGAM, B-type PGM, cofactor-dependent phosphoglycerate mutase, dPGAM, DPGM, dPGM-B, EC 2.7.5.3, EC 3.1.3.13, EC 5.4.2.1, EntD, PGAM, PGAM1, PGAM2, PGM, phosphoglycerate mutase, phosphoglycerate mutase 1, phosphoglycerate mutase type B, Phosphoglyceromutase, Rv3214, ScPGM, SSO2236, Sts-1
ECTree
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rose, Z.B.
The enzymology of 2,3-bisphosphoglycerate
Adv. Enzymol. Relat. Areas Mol. Biol.
51
211-253
1980
Saccharomyces cerevisiae, Gallus gallus, Oryctolagus cuniculus, Homo sapiens, Sus scrofa
Ray, W.J.; Peck, E.J.
Phosphomutases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
6
407-477
1972
Gallus gallus, Oryctolagus cuniculus, Saccharomyces cerevisiae, Sus scrofa
-
Grisolia, S.
Phosphoglyceric acid mutases
Methods Enzymol.
5
236-242
1962
Saccharomyces cerevisiae
-
Rigden, D.J.; Alexeev, D.; Phillips, S.E.; Fothergill-Gilmore, L.A.
The 2.3 A X-ray crystal structure of S. cerevisiae phosphoglycerate mutase
J. Mol. Biol.
276
449-459
1998
Saccharomyces cerevisiae (P00950), Saccharomyces cerevisiae
Durany, N.; Joseph, J.; Cruz-Sanchez, F.F.; Carreras, J.
Phosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase and creatine kinase activity and isoenzymes in human brain tumors
Br. J. Cancer
76
1139-1149
1997
Homo sapiens
Durany, N.; Joseph, J.; Campo, E.; Molina, R.; Carreras, J.
Phosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase and enolase activity and isoenzymes in lung, colon and liver carcinomas
Br. J. Cancer
75
969-977
1997
Homo sapiens
Price, R.M.; Nairn, J.; Price, N.C.; Fothergill-Gilmore, L.A.
The reaction of phosphoglycerate mutase from Schizosaccharomyces pombe with diethylpyrocarbonate
Biochem. Soc. Trans.
24
324S
1996
Schizosaccharomyces pombe
Durany, N.; Carreras, J.
Distribution of phosphoglycerate mutase isozymes in rat, rabbit and human tissues
Comp. Biochem. Physiol. B
114
217-223
1996
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Nairn, J.; Price, N.C.; Kelly, S.M.; Rigden, D.; Fothergill-Gilmore, L.A.; Krell, T.
Phosphoglycerate mutase from Schizosaccharomyces pombe: development of an expression system and characterisation of three histidine mutants of the enzyme
Biochim. Biophys. Acta
1296
69-75
1996
Schizosaccharomyces pombe
Grana, X.; Perez de la Ossa, P.; Broceno, C.; Stoecker, M.; Garriga, J.; Puigdomenech, P.; Climent, F.
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase is conserved among different phylogenic kingdoms
Comp. Biochem. Physiol. B
112
287-293
1995
Homo sapiens
Esteller, M.; Urena, J.; Carreras, J.; Martelly, I.; Climent, F.
Thyroid hormone stimulates phosphoglycerate activity and isozyme transition in rat muscle tissues
Life Sci.
54
533-538
1994
Rattus norvegicus
White, P.J.; Nairn, J.; Price, N.C.; Nimmo, H.G.; Coggins, J.R.; Hunter, I.S.
Phosphoglycerate mutase from Streptomyces coelicolor A3(2): purification and characterization of the enzyme and cloning and sequence analysis of the gene
J. Bacteriol.
174
434-440
1992
Streptomyces coelicolor
White, M.F.; Fothergill-Gilmore, L.A.
Development of a mutagenesis, expression and purification system for yeast phosphoglycerate mutase
Eur. J. Biochem.
207
709-714
1992
Saccharomyces cerevisiae
White, M.; Fothergill-Gilmore L.A.
Mutase versus synthase: the phosphoglycerate mutase family studied by protein engineering
Biochem. Soc. Trans.
18
257
1990
Saccharomyces cerevisiae
Urena, J.M.; Egea, G.; Grana, X.; Castella, J.; Marsal, J.; Carreras, J.; Climent, F.
Location of phosphoglycerate mutase in rat skeletal muscle. An immunological and biochemical study
Eur. J. Cell Biol.
51
151-156
1990
Rattus norvegicus
Edwards, R.J.; Carter, N.D.; Jeffery, S.; Yates, S.
Purification of human muscle phosphoglycerate mutase by fast protein liquid chromatography based on hydrophobic interactions
J. Chromatogr.
490
424-431
1989
Homo sapiens
Batke, J.; Nazaryan, K.B.; Karapetian, N.H.
Complex of brain D-phosphoglycerate mutase and gamma enolase and its reactivation by D-glycerate 2,3-bisphosphate
Arch. Biochem. Biophys.
264
510-518
1988
Bos taurus
Castella, J.; Urena, J.; Ludevid, D.; Carreras, J.; Climent, F.
Immunological properties of rat phosphoglycerate mutase isozymes
Biochim. Biophys. Acta
956
97-102
1988
Rattus norvegicus
Johnson, C.M.; Price, N.C.
How similar are the phosphoglycerate mutases from yeast and rabbit muscle?
Biochem. Soc. Trans.
15
247-248
1987
Saccharomyces cerevisiae, Oryctolagus cuniculus
-
Prehu, C.; Prehu, M.O.; Kechemir, D.; Rosa, R.
Purification of the M-type phosphoglyceromutase from rabbit muscle
J. Chromatogr.
360
203-210
1986
Oryctolagus cuniculus
Rosa, R.; Calvin, M.C.; Prehu, M.O.; Arous, N.
Purification of human erythrocyte phosphoglyceromutase
J. Chromatogr.
285
203-209
1984
Homo sapiens
Kulbe, K.D.; Foellmer, H.; Fuchs, J.
Simultaneous purification of glyceraldehyde-3-phosphate dehydrogenase, 3-phosphoglycerate kinase, and phosphoglycerate mutase from pig liver and muscle
Methods Enzymol.
90
498-511
1982
Sus scrofa
Scopes, R.K.; Stoter, A.
Purification of all glycolytic enzymes from one muscle extract
Methods Enzymol.
90
479-490
1982
Oryctolagus cuniculus
Bartrons, R.; Carreras, J.
Purification and characterization of phosphoglycerate mutase isozymes from pig heart
Biochim. Biophys. Acta
708
167-177
1982
Sus scrofa
Ikura, K.; Narita, H.; Sasaki, R.; Chiba, H.
Immunochemical and enzymatic properties of bisphosphoglyceromutase/phosphatase and phosphoglyceromutase from human erythrocytes
Eur. J. Biochem.
89
23-31
1978
Homo sapiens
Hill, B.; Attwood, M.M.
Purification and characterization of phosphoglycerate mutase from methanol-grown Hyphomicrobium X and Pseudomonas AM1
J. Gen. Microbiol.
96
185-193
1976
Hyphomicrobium sp., Pseudomonas sp., Pseudomonas sp. AM1, Hyphomicrobium sp. X
Sheibley, R.H.; Hass, L.F.
Isolation and partial characterization of monophosphoglycerate mutase from human erythrocytes
J. Biol. Chem.
251
6699-6704
1976
Homo sapiens
Hass, L.F.; Sheibley, R.H.; Kappel, W.K.; Miller, K.B.
A comparison of some of the physical and chemical properties of the phosphoglycerate mutases from human erythrocytes
Biochem. Biophys. Res. Commun.
72
976-983
1976
Homo sapiens
Hartman, F.C.; Norton, I.L.
Detection of an essential sulfhydryl group in phosphoglycerate mutase with an affinity-labeling reagent
J. Biol. Chem.
251
4565-4569
1976
Oryctolagus cuniculus
Sasaki, R.; Utsumi, S.; Sugimoto, E.; Chiba, H.
Subunit structure and multifunctional properties of yeast phosphoglyceromutase
Eur. J. Biochem.
66
523-533
1976
Saccharomyces cerevisiae
Grisolia, S.; Carreras, J.
Phosphoglycerate mutase from yeast, chicken breast muscle, and kidney (2,3-PGA-dependent)
Methods Enzymol.
42
435-450
1975
Saccharomyces cerevisiae, Gallus gallus, Sus scrofa
D'Alessio, G.; Josse, J.
Phosphoglycerate kinase, phosphoglyceromutase from Escherichia coli
Methods Enzymol.
42
139-144
1975
Escherichia coli
Sakoda, S.; Shanske, D.; DiMauro, S.; Schon, E.A.
Isolation of a cDNA encoding the B isozyme of human phosphoglycerate mutase (PGAM) and characterization of the PGAM gene family
J. Biol. Chem.
263
16899-16905
1988
Homo sapiens
Shanske, S.; Sakoda, S.; Hermodson, M.A.; DiMauro, S.; Schon, E.A.
Isolation of cDNA encoding the muscle-specific subunit of human phosphoglycerate mutase
J. Biol. Chem.
262
14612-14617
1987
Homo sapiens
Crowhurst, G.S.; Dalby, A.R.; Isupov, M.N.; Campbell, J.W.; Littlechild, J.A.
Structure of a phosphoglycerate mutase:3-phosphoglyceric acid complex at 1.7 A
Acta Crystallogr. Sect. D
55
1822-1826
1999
Saccharomyces cerevisiae (P00950), Saccharomyces cerevisiae
Walter, R.A.; Nairn, J.; Duncan, D.; Price, N.C.; Kelly, S.M.; Rigden, D.J.; Fothergill-Gilmore, L.A.
The role of the C-terminal region in phosphoglycerate mutase
Biochem. J.
337
89-95
1999
Saccharomyces cerevisiae, Schizosaccharomyces pombe
-
Nairn, J.; Duncan, D.; Price, N.E.; Kelly, S.M.; Fothergill-Gilmore, L.A.; Uhrinova, S.; Barlow, P.N.; Rigden, D.J.; Price, N.C.
Characterization of active-site mutants of Schizosaccharomyces pombe phosphoglycerate mutase. Elucidation of the roles of amino acids involved in substrate binding and catalysis
Eur. J. Biochem.
267
7065-7074
2000
Schizosaccharomyces pombe
Rigden, D.J.; Walter, R.A.; Phillips, S.E.; Fothergill-Gilmore, L.A.
Sulphate ions observed in the 2.12 A structure of a new crystal form of S. cerevisiae phosphoglycerate mutase provide insights into understanding the catalytic mechanism
J. Mol. Biol.
286
1507-1517
1999
Saccharomyces cerevisiae (P00950), Saccharomyces cerevisiae
Rigden, D.J.; Walter, R.A.; Phillips, S.E.; Fothergill-Gilmore, L.A.
Polyanionic inhibitors of phosphoglycerate mutase: combined structural and biochemical analysis
J. Mol. Biol.
289
691-699
1999
Saccharomyces cerevisiae (P00950), Saccharomyces cerevisiae, Schizosaccharomyces pombe
Uhrinova, S.; Uhrin, D.; Nairn, J.; Price, N.C.; Fothergill-Gilmore, L.A.; Barlow, P.N.
Solution structure and dynamics of an open beta-sheet, glycolytic enzyme, monomeric 23.7 kDa phosphoglycerate mutase from Schizosaccharomyces pombe
J. Mol. Biol.
306
275-290
2001
Schizosaccharomyces pombe (P36623), Schizosaccharomyces pombe
Bond, C.S.; White, M.F.; Hunter, W.N.
Mechanistic implications for Escherichia coli cofactor-dependent phosphoglycerate mutase based on the high-resolution crystal structure of a vanadate complex
J. Mol. Biol.
316
1071-1081
2002
Escherichia coli
Muller, P.; Sawaya, M.R.; Pashkov, I.; Chan, S.; Nguyen, C.; Wu, Y.; Perry, L.J.; Eisenberg, D.
The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase
Acta Crystallogr. Sect. D
61
309-315
2005
Mycobacterium tuberculosis
Watkins, H.A.; Yu, M.; Baker, E.N.
Cloning, expression, purification and preliminary crystallographic data for Rv3214 (EntD), a predicted cofactor-dependent phosphoglycerate mutase from Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
F61
753-755
2005
Mycobacterium tuberculosis
Wang, Y.; Wei, Z.; Liu, L.; Cheng, Z.; Lin, Y.; Ji, F.; Gong, W.
Crystal structure of human B-type phosphoglycerate mutase bound with citrate
Biochem. Biophys. Res. Commun.
331
1207-1215
2005
Homo sapiens
de Atauri, P.; Repiso, A.; Oliva, B.; Vives-Corrons, J.L.; Climent, F.; Carreras, J.
Characterization of the first described mutation of human red blood cell phosphoglycerate mutase
Biochim. Biophys. Acta
1740
403-410
2005
Homo sapiens
Repiso, A.; Ramirez Bajo, M.J.; Corrons, J.L.; Carreras, J.; Climent, F.
Phosphoglycerate mutase BB isoenzyme deficiency in a patient with non-spherocytic anemia: familial and metabolic studies
Haematologica
90
257-259
2005
Homo sapiens
Gonzalez-Cinca, N.; Perez de la Ossa, P.; Carreras, J.; Climent, F.
Effects of thyroid hormone and hypoxia on 2,3-bisphosphoglycerate, bisphosphoglycerate synthase and phosphoglycerate mutase in rabbit erythroblasts and reticulocytes in vivo
Horm. Res.
62
191-196
2004
Oryctolagus cuniculus
Kleinman, H.; Ford, B.; Keller, J.; Carpino, N.; Nassar, N.
Crystallization and initial crystal characterization of the C-terminal phosphoglycerate mutase homology domain of Sts-1
Acta Crystallogr. Sect. F
F62
218-220
2006
Mus musculus
Hakobyan, D.; Nazaryan, K.
Investigation of interaction between enolase and phosphoglycerate mutase using molecular dynamics simulation
J. Biomol. Struct. Dyn.
23
625-633
2006
Saccharomyces cerevisiae
Evans, M.J.; Morris, G.M.; Wu, J.; Olson, A.J.; Sorensen, E.J.; Cravatt, B.F.
Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides
Mol. Biosyst.
3
495-506
2007
Homo sapiens (P18669), Homo sapiens
Kajiwara, K.; Sunaga, K.; Tsuda, T.; Sugaya, A.; Sugaya, E.; Kimura, M.
Peony root extract upregulates transthyretin and phosphoglycerate mutase in mouse cobalt focus seizure
Biochem. Biophys. Res. Commun.
371
375-379
2008
Mus musculus (Q9DBJ1), Mus musculus
Qiu, H.; Zhao, S.; Xu, X.; Yerle, M.; Liu, B.
Assignment and expression patterns of porcine muscle-specific isoform of phosphoglycerate mutase gene
J. Genet. Genomics
35
257-260
2008
Sus scrofa (B5KJG2), Sus scrofa (B5KJG3), Sus scrofa
Jacobowitz, D.M.; Jozwik, C.; Fukuda, T.; Pollard, H.B.
Immunohistochemical localization of phosphoglycerate mutase in capillary endothelium of the brain and periphery
Microvasc. Res.
76
89-93
2008
Rattus norvegicus
Kowalski, W.; Gizak, A.; Rakus, D.
Phosphoglycerate mutase in mammalian striated muscles: subcellular localization and binding partners
FEBS Lett.
583
1841-1845
2009
Oryctolagus cuniculus, Rattus norvegicus
iao, Y.; Jin, X.; Yan, J.; Jiao, F.; Li, X.; Roe, B.A.; Jarrett, H.W.; Gu, W.
An insertion of intracisternal A-particle retrotransposon in a novel member of the phosphoglycerate mutase family in the lew allele of mutant mice
Genes Genet. Syst.
84
327-334
2009
Mus musculus
Kimura, A.; Sakurai, T.; Koumura, A.; Yamada, M.; Hayashi, Y.; Tanaka, Y.; Hozumi, I.; Tanaka, R.; Takemura, M.; Seishima, M.; Inuzuka, T.
High prevalence of autoantibodies against phosphoglycerate mutase 1 in patients with autoimmune central nervous system diseases
J. Neuroimmunol.
219
105-108
2010
Rattus norvegicus
Ren, F.; Wu, H.; Lei, Y.; Zhang, H.; Liu, R.; Zhao, Y.; Chen, X.; Zeng, D.; Tong, A.; Chen, L.; Wei, Y.; Huang, C.
Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma
Mol. Cancer
9
81
2010
Homo sapiens (P18669), Homo sapiens
Hakobyan, D.; Nazaryan, K.
Molecular dynamics study of interaction and substrate channeling between neuron-specific enolase and B-type phosphoglycerate mutase
Proteins
78
1691-1704
2010
Homo sapiens
Solem, C.; Petranovic, D.; Koebmann, B.; Mijakovic, I.; Jensen, P.R.
Phosphoglycerate mutase is a highly efficient enzyme without flux control in Lactococcus lactis
J. Mol. Microbiol. Biotechnol.
18
174-180
2010
Lactococcus lactis subsp. lactis, Lactococcus lactis subsp. lactis IL1403
Davies, D.R.; Staker, B.L.; Abendroth, J.A.; Edwards, T.E.; Hartley, R.; Leonard, J.; Kim, H.; Rychel, A.L.; Hewitt, S.N.; Myler, P.J.; Stewart, L.J.
An ensemble of structures of Burkholderia pseudomallei 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Acta Crystallogr. Sect. F
67
1044-1050
2011
Burkholderia pseudomallei (Q3JWH7), Burkholderia pseudomallei, Burkholderia pseudomallei 1710b (Q3JWH7)
Haferkamp, P.
Biochemical studies of enzymes involved in glycolysis of the thermoacidophilic crenarchaeon Sulfolobus solfataricus
PH. D. Thesis Universität Duisburg-Essen
2011
0000
2011
Saccharolobus solfataricus (Q97WI1), Saccharolobus solfataricus DSM 1617 (Q97WI1)
-
Li, Z.; Zhang, H.; Zhang, J.; Xi, L.; Yang, G.; Wang, S.; Zhou, Q.; Zhang, X.; Zhang, J.
Brucella abortus phosphoglyceromutase and dihydrodipicolinate reductase induce Th1 and Th2-related immune responses
World J. Microbiol. Biotechnol.
34
22
2018
Brucella abortus (Q2YJN6), Brucella abortus S2308 (Q2YJN6)
Wang, P.; Jiang, L.; Cao, Y.; Zhang, X.; Chen, B.; Zhang, S.; Huang, K.; Ye, D.; Zhou, L.
Xanthone derivatives as phosphoglycerate mutase 1 inhibitors Design, synthesis, and biological evaluation
Bioorg. Med. Chem.
26
1961-1970
2018
Homo sapiens (P18669)
Mikawa, T.; Maruyama, T.; Okamoto, K.; Nakagama, H.; Lleonart, M.E.; Tsusaka, T.; Hori, K.; Murakami, I.; Izumi, T.; Takaori-Kondo, A.; Yokode, M.; Peters, G.; Beach, D.; Kondoh, H.
Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2
J. Cell Biol.
204
729-745
2014
Mus musculus (O70250), Homo sapiens (P15259)
Patil, Y.; Junghare, M.; Müller, N.
Fermentation of glycerol by Anaerobium acetethylicum and its potential use in biofuel production
Microb. Biotechnol.
10
203-217
2017
Anaerobium acetethylicum (A0A1D3TPC3), Anaerobium acetethylicum (A0A1D3TXG7)
Wang, P.; Jiang, L.; Cao, Y.; Ye, D.; Zhou, L.
The design and synthesis of n-xanthone benzenesulfonamides as novel phosphoglycerate mutase 1 (PGAM1) inhibitors
Molecules
23
E1396
2018
Homo sapiens (P18669)
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