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5.3.99.6: allene-oxide cyclase

This is an abbreviated version!
For detailed information about allene-oxide cyclase, go to the full flat file.

Word Map on EC 5.3.99.6

Reaction

(9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate
=
(15Z)-12-oxophyto-10,15-dienoate

Synonyms

AaAOC, Allene oxide cyclase, allene oxide oxidase, allene oxide oxidase 3, AOC, AOC1, AOC2, AOC3, Cyclase, allene oxide, EC 5.3.99.1, JcAOC, OsAOC, PnAOC

ECTree

     5 Isomerases
         5.3 Intramolecular oxidoreductases
             5.3.99 Other intramolecular oxidoreductases
                5.3.99.6 allene-oxide cyclase

Crystallization

Crystallization on EC 5.3.99.6 - allene-oxide cyclase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
modeling of complexes with substrate 12,13-epoxy-9,11,15-octadecatrienoic acid and product 12-oxo-phytodienoic acid. Reaction is promoted by anchimeric assistance through a conserved Glu residue. The transition state with a pentadienyl carbocation and an oxyanion is stabilized by a strongly bound water molecule and favorable pi-pi interactions with aromatic residues in the cavity
-
purified recombinant free isozyme AOC2, X-ray diffraction structure determination and analysis at 1.95 A resolution
purified recombinant isozyme AOC1, free or in complex with substrate analogue 12,13S-epoxy-9Z,15Z-octadecadienoic acid, X-ray diffraction structure determination and analysis at 1.35-2.0 A resolution