5.3.99.2: Prostaglandin-D synthase

This is an abbreviated version!
For detailed information about Prostaglandin-D synthase, go to the full flat file.

Word Map on EC 5.3.99.2

5.3.99.2

cerebrospinal

arachidonic

cox-2

csf

cyclooxygenase

prostanoids

lipocalins

indomethacin

creatinine

cystatin

mast

sleep

glomerular

seminal

allergic

leptomeninges

aspirin

eicosanoids

thromboxane

leukotriene

nonsteroidal

plexus

nsaid

medicine

synthase-1

subarachnoidal

1.14.99.1

ventrolateral

pgf2alpha

transthyretin

preoptic

rhinorrhea

endoperoxide

fistula

sleep-promoting

nephelometric

beta2-microglobulin

pghs-1

arachnoid

hydroperoxidase

sleep-wake

analysis

synthesis

nutrition

Reaction

(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate

(5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate

Synonyms

beta-Trace, Beta-trace protein, betaTP, glutathione dependent prostaglandine D2 synthase, Glutathione-dependent PGD synthetase, glutathione-dependent prostaglandin D2 synthase, Glutathione-independent PGD synthetase, H-PGDS, haematopoietic PGD synthase, haematopoietic prostaglandin D synthase, Hematopoietic prostaglandin D synthase, hematopoietic prostaglandin D2 synthase, HPGDS, Isomerase, prostaglanin R2 D-, L-PGDS, L-prostaglandin D synthase, L-type prostaglandin synthase, lipocalin prostaglandin D synthase, lipocalin type prostaglandin D synthase, lipocalin-prostaglandin D synthase, lipocalin-type PG D synthase, lipocalin-type PGD synthase, lipocalin-type Pgds, lipocalin-type prostaglandin d synthase, lipocalin-type prostaglandin D2 synthase, lipocaline-type prostaglandin D synthase, PGD synthase, PGD-S, PGD2 synthase, PGD2 synthetase, PGDS, PGDS2, PGH-PGD isomerase, PGH2 D-isomerase, Prostaglandin D synthase, Prostaglandin D2 synthase, prostaglandin D2 synthetase, prostaglandin synthase, Prostaglandin-D synthase, Prostaglandin-H2 D-isomerase, Prostaglandin-R-prostaglandin D isomerase, PTGDS

ECTree

5 Isomerases

5.3 Intramolecular oxidoreductases

5.3.99 Other intramolecular oxidoreductases

5.3.99.2 Prostaglandin-D synthase

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Results	in table
32	Activating Compound
276	AA Sequence
32	Application
1	CAS Registry Number
54	Cloned(Commentary)
14	Cofactor
14	Crystallization (Commentary)
1617	Disease/ Diagnostics
12	Expression
24	General Information
2	General Stability
89	IC50 Value
211	Inhibitors
13	kcat/KM [mM/s]
16	Ki Value [mM]
47	KM Value [mM]
22	Localization
5	Metals/Ions
23	Molecular Weight [Da]
75	Natural Substrates/ Products (Substrates)
278	Organism
8	Pathway
137	PDB ID
8	pH Optimum
4	pH Stability
2	pI Value
5	Posttranslational Modification
80	Protein Variants
37	Purification (Commentary)
1	Reaction
14	Reaction Type
139	Reference
2	Renatured (Commentary)
155	Source Tissue
10	Specific Activity [micromol/min/mg]
4	Storage Stability
113	Substrates and Products (Substrate)
22	Subunits
153	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
7	Temperature Stability [°C]
19	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 5.3.99.2 - Prostaglandin-D synthase

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19000

x * 19000, SDS-PAGE

20000

L-PGDS

20749

x * 20749 or 21232, calculation from nucleotide sequence

3124

21000

Mus musculus

O09114

L-PGDS bound to biliverdin

705407

21016

Homo sapiens

x * 21016, calculation from nucleotide sequence

3123

22732

Gallus gallus

O73888

x * 22732, deduced from nucleotide sequence

23000

23298

x * 23298, deduced from nucleotide sequence

649720

23359

Homo sapiens

x * 23359, deduced from nucleotide sequence

25000

26000

28000

x * 28000, SDS-PAGE, molecular mass is the same for several isoforms showing pI values from 4.2 to 7.0

682618

28600

Danio rerio

Q8QGV4

x * 28600, calculated

34000

gel filtration

80000

1 * 80000, SDS-PAGE

80000 - 85000

85000

gel filtration