5.3.99.10: thiazole tautomerase
This is an abbreviated version!
For detailed information about thiazole tautomerase, go to the full flat file.
Reaction
Synonyms
tenI
ECTree
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General Information
General Information on EC 5.3.99.10 - thiazole tautomerase
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metabolism
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TenI is involved in the thiamin thiazole biosynthesis. In Bacillus subtilis, the thiazole tautomer (R,Z)-2-(2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate is formed by an oxidative condensation of glycine, 1-deoxy-D-xylulose-5-phosphate, and cysteine
physiological function
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TenI shows no thiamin phosphate synthase activity, but functionsas a thiazole tautomerase, substrates phosphate and histidine 122 act as the acid/base residues involved in catalysis, reaction mechanism, overview. TenI does not affect glycine oxidase, thiamin phosphate synthase, or ThiS-COSH formation