5.3.3.8: DELTA3-DELTA2-enoyl-CoA isomerase
This is an abbreviated version!
For detailed information about DELTA3-DELTA2-enoyl-CoA isomerase, go to the full flat file.
Word Map on EC 5.3.3.8
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5.3.3.8
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beta-oxidation
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peroxisomal
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unsaturated
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hydratase
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auxiliary
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2,4-dienoyl-coa
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isomerization
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oleic
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odd-numbered
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3-ketoacyl-coa
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crotonase
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trifunctional
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thiolase
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protic
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d-3-hydroxyacyl-coa
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4.2.1.17
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1.3.1.34
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medicine
- 5.3.3.8
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beta-oxidation
- peroxisomal
- unsaturated
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hydratase
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auxiliary
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2,4-dienoyl-coa
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isomerization
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oleic
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odd-numbered
- 3-ketoacyl-coa
- crotonase
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trifunctional
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thiolase
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protic
- d-3-hydroxyacyl-coa
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4.2.1.17
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1.3.1.34
- medicine
Reaction
Synonyms
2,3-Enoyl-CoA isomerase, 2,3-trans-enoyl-CoA isomerase, 3,2-trans-Enoyl-CoA isomerase, 3,2-trans-enoyl-coenzyme A isomerase, 3-2trans-Enoyl-CoA isomerase, 3-cis-2-trans-Enoyl-CoA isomerase, Acetylene-allene isomerase, AtECI1, AtECI2, AtECI3, D3,D2-enoyl-CoA isomerase, DCI, DELTA3,DELTA2-enoyl CoA isomerase, DELTA3,DELTA2-enoyl-CoA isomerase, DELTA3-cis,DELTA2-trans-Enoyl-CoA isomerase, DELTA3-cis-DELTA2-trans-enoyl-CoA isomerase, Delta3-Delta2-enoyl-CoA isomerase, DELTA3DELTA2-enoyl CoA isomerase, dodecenoyl coenzyme A DELTA isomerase, Dodecenoyl-CoA delta-isomerase, dodecenoyl-CoA DELTA3-cis-DELTA2-trans-isomerase, dodecenoyl-coenzyme A DELTA isomerase, ECI, ECI1, Eci1p, ECI2, Eci3, Hepatocellular carcinoma-associated antigen 88, Isomerase, dodecenoyl coenzyme A Delta-, Long-chain DELTA3,DELTA2-enoyl-CoA isomerase, MECI, MFE1, PECI, Short chain DELTA3,DELTA2-enoyl-CoA isomerase
ECTree
5.3.3.8 DELTA3-DELTA2-enoyl-CoA isomeraseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 5.3.3.8 - DELTA3-DELTA2-enoyl-CoA isomerase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
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enzyme participates in the degradation of unsaturated fatty acids through beta-oxidation
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?
additional information
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oleate is mostly (about 90%) degraded via beta-oxidation in Escherichia coli. A small amount of 2-trans,5-cis-tetradecadienoyl-CoA is diverted from the pathway via conversion to 3,5-cis-tetradecadienoyl-CoA by DELTA3,DELTA2-enoyl-CoA isomerase. The CoA-bound intermediate, which would strongly inhibit beta-oxidation if allowed to accumulate, is hydrolyzed and the resultant 3,5-tetradecadienoate is excreted into the growth medium.
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?
additional information
?
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Escherichia coli B / ATCC 11303
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oleate is mostly (about 90%) degraded via beta-oxidation in Escherichia coli. A small amount of 2-trans,5-cis-tetradecadienoyl-CoA is diverted from the pathway via conversion to 3,5-cis-tetradecadienoyl-CoA by DELTA3,DELTA2-enoyl-CoA isomerase. The CoA-bound intermediate, which would strongly inhibit beta-oxidation if allowed to accumulate, is hydrolyzed and the resultant 3,5-tetradecadienoate is excreted into the growth medium.
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?
additional information
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the enzyme is essential for unsaturated fatty acid metabolism
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?
additional information
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involved in mitochondrial beta-oxidation of unsaturated fatty acids. Decreased levels of this enzyme in metastatic breast cancer cells might have impact on the aberrant behavior of cancer cells
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?
additional information
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involved in mitochondrial beta-oxidation of unsaturated fatty acids. Decreased levels of this enzyme in metastatic breast cancer cells might have impact on the aberrant behavior of cancer cells
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?
additional information
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catalyzes the transformation of 3-cis- and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates
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?
additional information
?
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catalyzes the transformation of 3-cis- and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates
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?
additional information
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enzyme is important for the degradation of unsaturated fatty acids in the beta-oxidation system
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?
additional information
?
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the enzyme is essential for unsaturated fatty acid metabolism
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?
additional information
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key enzyme in mitochondrial beta-oxidation of unsaturated fatty acids
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?
additional information
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enzyme is responsible for the positional and geometric isomerization of beta,gamma-unsaturated fatty acyl-CoA intermediates arising during beta-oxidation of unsaturated long-chain fatty acids
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?
additional information
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mitochondrial enzyme is markedly induced by peroxisome proliferators, di-(2-ethylhexyl)phthalate and clofibrate
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?
additional information
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enzyme is important for the degradation of unsaturated fatty acids in the beta-oxidation system
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?
additional information
?
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enzyme is important for the degradation of unsaturated fatty acids in the beta-oxidation system
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?
additional information
?
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key enzyme in the degradation of unsaturated fatty acids
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?
additional information
?
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involved in the enzymatic degradation of the cis-olefinic system of monounsaturated and polyunsaturated fatty acids
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?
additional information
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auxiliary enzyme that is essential for the operation of the major pathway of oleate beta-oxidation
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?
additional information
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key enzyme for the beta-oxidation of unsaturated fatty acids
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?
additional information
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the enzyme is involved in beta-oxidation of unsaturated fatty acids
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?
additional information
?
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one of the key enzymes involved in fatty acid oxidation
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?
additional information
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one of the key enzymes involved in fatty acid oxidation
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?
additional information
?
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auxiliary enzyme required for beta-oxidation of unsaturated fatty acids
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?
additional information
?
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the enzyme is essential for the beta-oxidation of unsaturated fatty acids
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?
additional information
?
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the enzyme is essential for the beta-oxidation of unsaturated fatty acids
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?
additional information
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main pathway for 9-cis,11-trans-octadecadienoic acid degradation requires the participation of DELTA3,DELTA2-enoyl-CoA isomerase
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?
additional information
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the synthesis of polyhydroxyalkanoate in cells grown in media containing 10-cis-heptadecenoic acid is dependent on the presence of DELTA3,DELTA2-enoyl-CoA isomerase activity. Degradation of 10-trans-heptadecenoic acid through beta-oxidation is severly reduced in mutants devoid of DELTA3,DELTA2-enoyl-CoA isomerase. The synthesis of the intermediate 3-trans-enoyl-CoA in the absence of the DELTA3,DELTA2-enoyl-CoA isomerase leads to the blockage of the direct multifunctional enzyme dependent pathway in vivo
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?
additional information
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the synthesis of polyhydroxyalkanoate in cells grown in media containing 10-cis-heptadecenoic acid is dependent on the presence of DELTA3,DELTA2-enoyl-CoA isomerase activity. Degradation of 10-trans-heptadecenoic acid through beta-oxidation is severly reduced in mutants devoid of DELTA3,DELTA2-enoyl-CoA isomerase. The synthesis of the intermediate 3-trans-enoyl-CoA in the absence of the DELTA3,DELTA2-enoyl-CoA isomerase leads to the blockage of the direct multifunctional enzyme dependent pathway in vivo
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?
additional information
?
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main pathway for 9-cis,11-trans-octadecadienoic acid degradation requires the participation of DELTA3,DELTA2-enoyl-CoA isomerase
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