5.3.3.18: 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase

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For detailed information about 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase, go to the full flat file.

Reaction

Synonyms

paaG

ECTree

5 Isomerases

5.3 Intramolecular oxidoreductases

5.3.3 Transposing C=C bonds

5.3.3.18 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase

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2372	AA Sequence
2	Crystallization (Commentary)
1	General Information
2	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
8	Organism
6	Pathway
5	PDB ID
1	Purification (Commentary)
1	Reaction
6	Reference
5	Substrates and Products (Substrate)
2	Subunits
3	Synonyms
1	Systematic Name

General Information

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General Information on EC 5.3.3.18 - 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase

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physiological function

Escherichia coli

P77467

mutants with a deletion of paaG gene are unable to grow on phenylacetate as carbon source. Incubation of a paaG mutant with [U-13C8]phenylacetate yields ring-1,2-dihydroxy-1,2-dihydrophenylacetyl lactone. The paaG mutant also converts phenylacetate into ortho-hydroxyphenylacetate, a dead end product of phenylacetate catabolism. The catabolic pathway of phenylacetate involves CoA thioesters. Phenylacetyl-CoA is attacked by a ring-oxygenase/reductase, PaaABCDE proteins, generating a hydroxylated and reduced derivative of phenylacetyl-CoA. The intermediate CoA ester is further metabolized in a complex reaction sequence comprising enoyl-CoA isomerization/hydration, nonoxygenolytic ring opening, and dehydrogenation catalyzed by the PaaG and PaaZ proteins

714891