5.3.3.14: trans-2-decenoyl-[acyl-carrier protein] isomerase

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For detailed information about trans-2-decenoyl-[acyl-carrier protein] isomerase, go to the full flat file.

Reaction

Synonyms

FabM

ECTree

     5 Isomerases

         5.3 Intramolecular oxidoreductases

             5.3.3 Transposing C=C bonds

                5.3.3.14 trans-2-decenoyl-[acyl-carrier protein] isomerase

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Results	in table
10266	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
1	Crystallization (Commentary)
9	Inhibitors
4	Ki Value [mM]
2	KM Value [mM]
7	Molecular Weight [Da]
10	Organism
7	Pathway
34	PDB ID
1	pH Optimum
1	pH Range
1	Protein Variants
2	Purification (Commentary)
3	Reaction
10	Reference
2	Specific Activity [micromol/min/mg]
9	Substrates and Products (Substrate)
4	Subunits
1	Synonyms
1	Systematic Name
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 5.3.3.14 - trans-2-decenoyl-[acyl-carrier protein] isomerase

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SYSTEMATIC NAME

IUBMB Comments

decenoyl-[acyl-carrier protein] Delta2-trans-Delta3-cis-isomerase

While the enzyme from Escherichia coli is highly specific for the 10-carbon enoyl-ACP, the enzyme from Streptococcus pneumoniae can also use the 12-carbon enoyl-ACP as substrate in vitro but not 14- or 16-carbon enoyl-ACPs [3]. ACP can be replaced by either CoA or N-acetylcysteamine thioesters. The cis-3-enoyl product is required to form unsaturated fatty acids, such as palmitoleic acid and cis-vaccenic acid, in dissociated (or type II) fatty-acid biosynthesis.