5.3.2.6: 2-hydroxymuconate tautomerase

This is an abbreviated version!
For detailed information about 2-hydroxymuconate tautomerase, go to the full flat file.

Reaction

Synonyms

4-OT, 4-oxalocrotonate tautomerase, 4-oxalocrotonate tautomerase I, 4-oxalocrotonate tautomerase II, 4OT, AfDmpI, D-4-oxalocrotonate tautomerase, HpDmpI, L-4-oxalocrotonate tautomerase, OCA, PRAC, SAR1376, TomN, xylH, YwhB

ECTree

     5 Isomerases

         5.3 Intramolecular oxidoreductases

             5.3.2 Interconverting keto- and enol-groups

                5.3.2.6 2-hydroxymuconate tautomerase

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Results	in table
1459	AA Sequence
1	CAS Registry Number
17	Cloned(Commentary)
7	Crystallization (Commentary)
34	General Information
27	Inhibitors
46	kcat/KM [mM/s]
1	Ki Value [mM]
50	KM Value [mM]
5	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
159	Organism
17	Pathway
146	PDB ID
13	pH Optimum
45	Protein Variants
13	Purification (Commentary)
6	Reaction
43	Reference
1	Source Tissue
124	Substrates and Products (Substrate)
30	Subunits
83	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
1	Temperature Stability [°C]
46	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 5.3.2.6 - 2-hydroxymuconate tautomerase

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SYSTEMATIC NAME

IUBMB Comments

(2Z,4E)-2-hydroxyhexa-2,4-dienedioate keto-enol isomerase

Involved in the meta-cleavage pathway for the degradation of phenols, modified phenols and catechols. The enol form (2Z,4E)-2-hydroxyhexa-2,4-dienedioate is produced as part of this pathway and is converted to the keto form (3E)-2-oxohex-3-enedioate by the enzyme [6]. Another keto form, (4E)-2-oxohex-4-enedioate (4-oxalocrotonate), was originally thought to be produced by the enzyme [1,2] but later shown to be produced non-enzymically [5].