5.3.2.6: 2-hydroxymuconate tautomerase

This is an abbreviated version!
For detailed information about 2-hydroxymuconate tautomerase, go to the full flat file.

Reaction

Synonyms

4-OT, 4-oxalocrotonate tautomerase, 4-oxalocrotonate tautomerase I, 4-oxalocrotonate tautomerase II, 4OT, AfDmpI, D-4-oxalocrotonate tautomerase, HpDmpI, L-4-oxalocrotonate tautomerase, OCA, PRAC, SAR1376, TomN, xylH, YwhB

ECTree

     5 Isomerases

         5.3 Intramolecular oxidoreductases

             5.3.2 Interconverting keto- and enol-groups

                5.3.2.6 2-hydroxymuconate tautomerase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1459	AA Sequence
1	CAS Registry Number
17	Cloned(Commentary)
7	Crystallization (Commentary)
34	General Information
27	Inhibitors
46	kcat/KM [mM/s]
1	Ki Value [mM]
50	KM Value [mM]
5	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
159	Organism
17	Pathway
146	PDB ID
13	pH Optimum
45	Protein Variants
13	Purification (Commentary)
6	Reaction
43	Reference
1	Source Tissue
124	Substrates and Products (Substrate)
30	Subunits
83	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
1	Temperature Stability [°C]
46	Turnover Number [1/s]

Natural Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Natural Substrates Products on EC 5.3.2.6 - 2-hydroxymuconate tautomerase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Natural Substrate Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(2Z,4E)-2-hydroxyhexa-2,4-dienedioate

(3E)-2-oxohex-3-enedioate

10 entries

2-hydroxy-2,4-hexadienedioate

2-oxo-3-hexenedioate

2 entries

2-hydroxy-2,4-pentadienoate

2-oxopent-3-enoic acid

Bacillus subtilis

-

-

718847

-

-

?

2-hydroxymuconate

2-oxo-3-hexenedioate

4 entries

2-hydroxymuconate

4-oxalocrotonate

Paenibacillus sp.

C4TP07

-

704310

-

-

?

2-oxo-4(E)-hexenedioate

2-oxo-3(E)-hexenedioate

2 entries

2-oxo-4-hexenedioate

2-oxo-3-hexenedioate

7 entries

phenylenolpyruvate

phenylpyruvate

2 entries

(2Z,4E)-2-hydroxyhexa-2,4-dienedioate

(3E)-2-oxohex-3-enedioate

Bacillus subtilis

-

-

727314

-

-

?

(2Z,4E)-2-hydroxyhexa-2,4-dienedioate

(3E)-2-oxohex-3-enedioate

Escherichia coli

-

-

727327

-

-

?

(2Z,4E)-2-hydroxyhexa-2,4-dienedioate

(3E)-2-oxohex-3-enedioate

Leptothrix cholodnii

-

-

747133

-

-

r

(2Z,4E)-2-hydroxyhexa-2,4-dienedioate

(3E)-2-oxohex-3-enedioate

Leptothrix cholodnii SP-6

-

-

747133

-

-

r

(2Z,4E)-2-hydroxyhexa-2,4-dienedioate

(3E)-2-oxohex-3-enedioate

Methylibium petroleiphilum

A2SL37

-

726816

-

-

?

(2Z,4E)-2-hydroxyhexa-2,4-dienedioate

(3E)-2-oxohex-3-enedioate

Pseudomonas putida

-

-

727187

-

-

?

(2Z,4E)-2-hydroxyhexa-2,4-dienedioate

(3E)-2-oxohex-3-enedioate

Pseudomonas putida

-

-

726964, 746910, 747290, 747782, 748503, 749284

-

-

r

(2Z,4E)-2-hydroxyhexa-2,4-dienedioate

(3E)-2-oxohex-3-enedioate

Pseudomonas putida

Q01468

-

747133, 747537, 748742

-

-

r

(2Z,4E)-2-hydroxyhexa-2,4-dienedioate

(3E)-2-oxohex-3-enedioate

Staphylococcus aureus

Q6GH41

-

749336

-

-

r

(2Z,4E)-2-hydroxyhexa-2,4-dienedioate

(3E)-2-oxohex-3-enedioate

Staphylococcus aureus MRSA252

Q6GH41

-

749336

-

-

r

2-hydroxy-2,4-hexadienedioate

2-oxo-3-hexenedioate

Chloroflexus aurantiacus

A9W9U6

i.e. 2-hydroxymuconate

718874

-

-

r

2-hydroxy-2,4-hexadienedioate

2-oxo-3-hexenedioate

Chloroflexus aurantiacus J-10-fl

A9W9U6

i.e. 2-hydroxymuconate

718874

-

-

r

2-hydroxymuconate

2-oxo-3-hexenedioate

Pseudomonas putida

-

ketonization

718844

-

-

?

2-hydroxymuconate

2-oxo-3-hexenedioate

Pseudomonas putida

-

the conjugated enol, 2-hydroxymuconate is an unusually stable dienol that is reportedly generated in the course of bacterial catabolism of catechol by the enzymes of the meta-fission pathway

719633

the dienol ketonizes chemically in aqueous solution and enzymatically by the action of 4-oxalocrotonate tautomerase to either the beta,gamma-unsaturated ketone or its alpha,beta-conjugated isomer 2-oxo-3-trans-hexenedioate

-

r

2-hydroxymuconate

2-oxo-3-hexenedioate

Pseudomonas putida mt-2 / ATCC 33015 / DSM 3931 / NCIB 12182 / NCIMB 12182

-

ketonization

718844

-

-

?

2-hydroxymuconate

2-oxo-3-hexenedioate

Pseudomonas putida mt-2 / ATCC 33015 / DSM 3931 / NCIB 12182 / NCIMB 12182

-

the conjugated enol, 2-hydroxymuconate is an unusually stable dienol that is reportedly generated in the course of bacterial catabolism of catechol by the enzymes of the meta-fission pathway

719633

the dienol ketonizes chemically in aqueous solution and enzymatically by the action of 4-oxalocrotonate tautomerase to either the beta,gamma-unsaturated ketone or its alpha,beta-conjugated isomer 2-oxo-3-trans-hexenedioate

-

r

2-oxo-4(E)-hexenedioate

2-oxo-3(E)-hexenedioate

Pseudomonas putida

-

1,3-allylic isomerization

719636

-

-

?

2-oxo-4(E)-hexenedioate

2-oxo-3(E)-hexenedioate

Pseudomonas putida mt-2 / ATCC 33015 / DSM 3931 / NCIB 12182 / NCIMB 12182

-

1,3-allylic isomerization

719636

-

-

?

2-oxo-4-hexenedioate

2-oxo-3-hexenedioate

Pseudomonas putida

-

isomerization of unconjugated 2-oxo acids such as 2-oxo-4-hexenedioate, to its conjugated isomer via dienol intermediate 2-hydroxy-2,4-hexadienedioate, i.e. 2-hydroxymuconate

718830

-

-

?

2-oxo-4-hexenedioate

2-oxo-3-hexenedioate

Pseudomonas putida

-

ketonization process via dienol intermediate 2-hydroxymuconate and with Pro1 as a general base, one-proton transfer mechanism

720309

-

-

?

2-oxo-4-hexenedioate

2-oxo-3-hexenedioate

Pseudomonas putida

-

via dienol intermediate 2-hydroxymuconate

718844

-

-

?

2-oxo-4-hexenedioate

2-oxo-3-hexenedioate

Pseudomonas putida

-

via the intermediate 2-hydroxy-2,4-hexadienedioate, i.e. 2-hydroxymuconate

718847

-

-

?

2-oxo-4-hexenedioate

2-oxo-3-hexenedioate

Pseudomonas putida mt-2 / ATCC 33015 / DSM 3931 / NCIB 12182 / NCIMB 12182

-

isomerization of unconjugated 2-oxo acids such as 2-oxo-4-hexenedioate, to its conjugated isomer via dienol intermediate 2-hydroxy-2,4-hexadienedioate, i.e. 2-hydroxymuconate

718830

-

-

?

2-oxo-4-hexenedioate

2-oxo-3-hexenedioate

Pseudomonas putida mt-2 / ATCC 33015 / DSM 3931 / NCIB 12182 / NCIMB 12182

-

via dienol intermediate 2-hydroxymuconate

718844

-

-

?

2-oxo-4-hexenedioate

2-oxo-3-hexenedioate

Pseudomonas putida mt-2 / ATCC 33015 / DSM 3931 / NCIB 12182 / NCIMB 12182

-

via the intermediate 2-hydroxy-2,4-hexadienedioate, i.e. 2-hydroxymuconate

718847

-

-

?

phenylenolpyruvate

phenylpyruvate

Bacillus subtilis

-

-

718847

-

-

?

phenylenolpyruvate

phenylpyruvate

Pseudomonas putida

Q01468

-

748742

-

-

r